7TYM

Cryo-EM Structure of insulin receptor-related receptor (IRR) in active-state captured at pH 9. The 3D refinement was applied with C2 symmetry

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane
A	0043548	molecular_function	phosphatidylinositol 3-kinase binding
A	0043560	molecular_function	insulin receptor substrate binding
A	0046777	biological_process	protein autophosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0016020	cellular_component	membrane
B	0043548	molecular_function	phosphatidylinositol 3-kinase binding
B	0043560	molecular_function	insulin receptor substrate binding
B	0046777	biological_process	protein autophosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGlargleageestp.....VALK

Chain	Residue	Details
A	LEU959-LYS987

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV

Chain	Residue	Details
A	PHE1085-VAL1097

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site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DVYetdYYR

Chain	Residue	Details
A	ASP1113-ARG1121

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site_id	PS00430
Number of Residues	32
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mavpslwpwgaclpviflslgfgl...........................................................................................DTVEVCPS

Chain	Residue	Details
A	MET-25-SER6

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	348
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	ALA721-HIS895
B	ALA721-HIS895

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site_id	SWS_FT_FI2
Number of Residues	42
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	VAL896-PHE917
B	VAL896-PHE917

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site_id	SWS_FT_FI3
Number of Residues	706
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TYR918-HIS1271
B	TYR918-HIS1271

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site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP1089
B	ASP1089

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site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU959
A	LYS987
B	LEU959
B	LYS987

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site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305

Chain	Residue	Details
A	TYR1119
A	TYR1120
B	TYR1119
B	TYR1120

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site_id	SWS_FT_FI7
Number of Residues	20
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN21
A	ASN285
A	ASN385
A	ASN466
A	ASN502
A	ASN590
A	ASN608
A	ASN730
A	ASN859
A	ASN872
B	ASN21
B	ASN285
B	ASN385
B	ASN466
B	ASN502
B	ASN590
B	ASN608
B	ASN730
B	ASN859
B	ASN872

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