7TY6
Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatodihydrostilbene-2,2'-Disulfonic Acid (H2DIDS)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006820 | biological_process | monoatomic anion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015701 | biological_process | bicarbonate transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| A | 0030018 | cellular_component | Z disc |
| A | 0030492 | molecular_function | hemoglobin binding |
| A | 0030506 | molecular_function | ankyrin binding |
| A | 0030863 | cellular_component | cortical cytoskeleton |
| A | 0035811 | biological_process | negative regulation of urine volume |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043495 | molecular_function | protein-membrane adaptor activity |
| A | 0045852 | biological_process | pH elevation |
| A | 0048821 | biological_process | erythrocyte development |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0072659 | biological_process | protein localization to plasma membrane |
| A | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| A | 0170014 | cellular_component | ankyrin-1 complex |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
| B | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006820 | biological_process | monoatomic anion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
| B | 0007596 | biological_process | blood coagulation |
| B | 0008092 | molecular_function | cytoskeletal protein binding |
| B | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015701 | biological_process | bicarbonate transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| B | 0030018 | cellular_component | Z disc |
| B | 0030492 | molecular_function | hemoglobin binding |
| B | 0030506 | molecular_function | ankyrin binding |
| B | 0030863 | cellular_component | cortical cytoskeleton |
| B | 0035811 | biological_process | negative regulation of urine volume |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043495 | molecular_function | protein-membrane adaptor activity |
| B | 0045852 | biological_process | pH elevation |
| B | 0048821 | biological_process | erythrocyte development |
| B | 0051453 | biological_process | regulation of intracellular pH |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0072562 | cellular_component | blood microparticle |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| B | 0170014 | cellular_component | ankyrin-1 complex |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 164 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 150 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Discontinuously helical; Name=3","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Discontinuously helical; Name=10","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 60 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 142 |
| Details | Region: {"description":"Involved in anion transport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for anion transport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for anion-proton cotransport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"1885574","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"10861210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24121512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
