Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7TY6

Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatodihydrostilbene-2,2'-Disulfonic Acid (H2DIDS)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005452	molecular_function	solute:inorganic anion antiporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006820	biological_process	monoatomic anion transport
A	0006821	biological_process	chloride transport
A	0006873	biological_process	intracellular monoatomic ion homeostasis
A	0007596	biological_process	blood coagulation
A	0008509	molecular_function	monoatomic anion transmembrane transporter activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0015106	molecular_function	bicarbonate transmembrane transporter activity
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0017121	biological_process	plasma membrane phospholipid scrambling
A	0030018	cellular_component	Z disc
A	0030492	molecular_function	hemoglobin binding
A	0030506	molecular_function	ankyrin binding
A	0030863	cellular_component	cortical cytoskeleton
A	0035811	biological_process	negative regulation of urine volume
A	0042803	molecular_function	protein homodimerization activity
A	0043495	molecular_function	protein-membrane adaptor activity
A	0045852	biological_process	pH elevation
A	0048821	biological_process	erythrocyte development
A	0051453	biological_process	regulation of intracellular pH
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	0072659	biological_process	protein localization to plasma membrane
A	0140900	molecular_function	chloride:bicarbonate antiporter activity
A	0170014	cellular_component	ankyrin-1 complex
A	1902476	biological_process	chloride transmembrane transport
A	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
B	0005452	molecular_function	solute:inorganic anion antiporter activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006820	biological_process	monoatomic anion transport
B	0006821	biological_process	chloride transport
B	0006873	biological_process	intracellular monoatomic ion homeostasis
B	0007596	biological_process	blood coagulation
B	0008509	molecular_function	monoatomic anion transmembrane transporter activity
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0015106	molecular_function	bicarbonate transmembrane transporter activity
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015701	biological_process	bicarbonate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0017121	biological_process	plasma membrane phospholipid scrambling
B	0030018	cellular_component	Z disc
B	0030492	molecular_function	hemoglobin binding
B	0030506	molecular_function	ankyrin binding
B	0030863	cellular_component	cortical cytoskeleton
B	0035811	biological_process	negative regulation of urine volume
B	0042803	molecular_function	protein homodimerization activity
B	0043495	molecular_function	protein-membrane adaptor activity
B	0045852	biological_process	pH elevation
B	0048821	biological_process	erythrocyte development
B	0051453	biological_process	regulation of intracellular pH
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
B	0072659	biological_process	protein localization to plasma membrane
B	0140900	molecular_function	chloride:bicarbonate antiporter activity
B	0170014	cellular_component	ankyrin-1 complex
B	1902476	biological_process	chloride transmembrane transport
B	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate

Functional Information from PROSITE/UniProt

site_id	PS00219
Number of Residues	12
Details	ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY

Chain	Residue	Details
A	PHE379-TYR390

site_id	PS00220
Number of Residues	15
Details	ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL

Chain	Residue	Details
A	PHE526-LEU540

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1080
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	MET1-PRO403
B	GLN457-LEU459
B	PHE507-ARG518
B	LYS592-ARG602
B	THR685-SER700
B	LEU738-ARG760
B	SER801-GLY838
B	ARG870-VAL911
A	GLN457-LEU459
A	PHE507-ARG518
A	LYS592-ARG602
A	THR685-SER700
A	LEU738-ARG760
A	SER801-GLY838
A	ARG870-VAL911
B	MET1-PRO403

site_id	SWS_FT_FI2
Number of Residues	46
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	GLN404-LEU427
B	GLN404-LEU427

site_id	SWS_FT_FI3
Number of Residues	164
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	GLY428-MET435
A	SER477-GLU485
A	LYS542-THR570
A	ILE624-MET663
B	GLY428-MET435
B	SER477-GLU485
B	LYS542-THR570
B	ILE624-MET663

site_id	SWS_FT_FI4
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	GLY436-ALA456
B	GLY436-ALA456

site_id	SWS_FT_FI5
Number of Residues	32
Details	TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	LEU460-PHE476
B	LEU460-PHE476

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	TYR486-ALA506
B	TYR486-ALA506

site_id	SWS_FT_FI7
Number of Residues	44
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	TYR519-ILE541
B	TYR519-ILE541

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	ALA571-PHE591
B	ALA571-PHE591

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	ARG603-PHE623
B	ARG603-PHE623

site_id	SWS_FT_FI10
Number of Residues	40
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	MET664-ILE684
B	MET664-ILE684

site_id	SWS_FT_FI11
Number of Residues	36
Details	TRANSMEM: Helical; Name=9 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	GLY701-PHE719
B	GLY701-PHE719

site_id	SWS_FT_FI12
Number of Residues	34
Details	TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	GLY720-ALA737
B	GLY720-ALA737

site_id	SWS_FT_FI13
Number of Residues	40
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	ILE761-SER781
B	ILE761-SER781

site_id	SWS_FT_FI14
Number of Residues	36
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	ARG782-LEU800
B	ARG782-LEU800

site_id	SWS_FT_FI15
Number of Residues	60
Details	INTRAMEM: Discontinuously helical => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
A	ILE839-LEU869
B	ILE839-LEU869

site_id	SWS_FT_FI16
Number of Residues	2
Details	SITE: Important for anion transport

Chain	Residue	Details
A	LYS590
B	LYS590

site_id	SWS_FT_FI17
Number of Residues	2
Details	SITE: Important for anion-proton cotransport

Chain	Residue	Details
A	GLU681
B	GLU681

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269\|PubMed:2790053, ECO:0000269\|PubMed:701248

Chain	Residue	Details
A	MET1
B	MET1

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:10942405, ECO:0000269\|PubMed:1998697

Chain	Residue	Details
A	TYR8
A	TYR21
B	TYR8
B	TYR21

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:1998697

Chain	Residue	Details
A	TYR46
B	TYR46

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P23562

Chain	Residue	Details
A	SER185
B	SER185

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P04919

Chain	Residue	Details
A	SER350
B	SER350

site_id	SWS_FT_FI23
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:10942405

Chain	Residue	Details
A	TYR359
A	TYR904
B	TYR359
B	TYR904

site_id	SWS_FT_FI24
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:1885574

Chain	Residue	Details
A	CYS843
B	CYS843

site_id	SWS_FT_FI25
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:10861210, ECO:0000269\|PubMed:24121512, ECO:0000269\|PubMed:35835865

Chain	Residue	Details
A	ASN642
B	ASN642

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)