7TUX

Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with [(3S)-4-Hydroxy-3-[({2-amino-4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]butyl]phosphonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000310	molecular_function	xanthine phosphoribosyltransferase activity
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006166	biological_process	purine ribonucleoside salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0032265	biological_process	XMP salvage
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000310	molecular_function	xanthine phosphoribosyltransferase activity
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006166	biological_process	purine ribonucleoside salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0032265	biological_process	XMP salvage
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000310	molecular_function	xanthine phosphoribosyltransferase activity
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006166	biological_process	purine ribonucleoside salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0032265	biological_process	XMP salvage
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000310	molecular_function	xanthine phosphoribosyltransferase activity
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006166	biological_process	purine ribonucleoside salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0032265	biological_process	XMP salvage
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDTGkT

Chain	Residue	Details
A	VAL140-THR152

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	ASP148
B	ASP148
C	ASP148
D	ASP148

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	LYS77
D	LYS77
D	GLU144
D	LYS176
A	GLU144
A	LYS176
B	LYS77
B	GLU144
B	LYS176
C	LYS77
C	GLU144
C	LYS176

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10433693

Chain	Residue	Details
A	ASP204
B	ASP204
C	ASP204
D	ASP204

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