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7TUB

The beta-tubulin folding intermediate IV

Functional Information from GO Data
ChainGOidnamespacecontents
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0003924molecular_functionGTPase activity
A0005198molecular_functionstructural molecule activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005641cellular_componentnuclear envelope lumen
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0007017biological_processmicrotubule-based process
A0015630cellular_componentmicrotubule cytoskeleton
A0019904molecular_functionprotein domain specific binding
A0030705biological_processcytoskeleton-dependent intracellular transport
A0031625molecular_functionubiquitin protein ligase binding
A0032794molecular_functionGTPase activating protein binding
A0032991cellular_componentprotein-containing complex
A0035578cellular_componentazurophil granule lumen
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042267biological_processnatural killer cell mediated cytotoxicity
A0042288molecular_functionMHC class I protein binding
A0044297cellular_componentcell body
A0044877molecular_functionprotein-containing complex binding
A0045121cellular_componentmembrane raft
A0045171cellular_componentintercellular bridge
A0046872molecular_functionmetal ion binding
A0050807biological_processregulation of synapse organization
A0051225biological_processspindle assembly
A0051301biological_processcell division
A0070062cellular_componentextracellular exosome
A0071895biological_processodontoblast differentiation
A0072686cellular_componentmitotic spindle
B0002199cellular_componentzona pellucida receptor complex
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005832cellular_componentchaperonin-containing T-complex
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005929cellular_componentcilium
B0006457biological_processprotein folding
B0007339biological_processbinding of sperm to zona pellucida
B0016887molecular_functionATP hydrolysis activity
B0032212biological_processpositive regulation of telomere maintenance via telomerase
B0034774cellular_componentsecretory granule lumen
B0035578cellular_componentazurophil granule lumen
B0044183molecular_functionprotein folding chaperone
B0044297cellular_componentcell body
B0045111cellular_componentintermediate filament cytoskeleton
B0045296molecular_functioncadherin binding
B0050821biological_processprotein stabilization
B0051082molecular_functionunfolded protein binding
B0061077biological_processchaperone-mediated protein folding
B0070062cellular_componentextracellular exosome
B0140662molecular_functionATP-dependent protein folding chaperone
B1904813cellular_componentficolin-1-rich granule lumen
B1904851biological_processpositive regulation of establishment of protein localization to telomere
B1904871biological_processpositive regulation of protein localization to Cajal body
B1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
C0005524molecular_functionATP binding
C0006457biological_processprotein folding
C0016887molecular_functionATP hydrolysis activity
C0051082molecular_functionunfolded protein binding
C0140662molecular_functionATP-dependent protein folding chaperone
D0003730molecular_functionmRNA 3'-UTR binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005832cellular_componentchaperonin-containing T-complex
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0006457biological_processprotein folding
D0007339biological_processbinding of sperm to zona pellucida
D0009615biological_processresponse to virus
D0016887molecular_functionATP hydrolysis activity
D0031681molecular_functionG-protein beta-subunit binding
D0032212biological_processpositive regulation of telomere maintenance via telomerase
D0044183molecular_functionprotein folding chaperone
D0044297cellular_componentcell body
D0048027molecular_functionmRNA 5'-UTR binding
D0048487molecular_functionbeta-tubulin binding
D0050821biological_processprotein stabilization
D0051082molecular_functionunfolded protein binding
D0061077biological_processchaperone-mediated protein folding
D0070062cellular_componentextracellular exosome
D0140662molecular_functionATP-dependent protein folding chaperone
D1904851biological_processpositive regulation of establishment of protein localization to telomere
D1904871biological_processpositive regulation of protein localization to Cajal body
D1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
E0002199cellular_componentzona pellucida receptor complex
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005576cellular_componentextracellular region
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005832cellular_componentchaperonin-containing T-complex
E0005874cellular_componentmicrotubule
E0006457biological_processprotein folding
E0007339biological_processbinding of sperm to zona pellucida
E0016887molecular_functionATP hydrolysis activity
E0031625molecular_functionubiquitin protein ligase binding
E0032212biological_processpositive regulation of telomere maintenance via telomerase
E0035578cellular_componentazurophil granule lumen
E0044183molecular_functionprotein folding chaperone
E0044297cellular_componentcell body
E0050821biological_processprotein stabilization
E0051082molecular_functionunfolded protein binding
E0051086biological_processchaperone mediated protein folding independent of cofactor
E0051131biological_processchaperone-mediated protein complex assembly
E0051973biological_processpositive regulation of telomerase activity
E0061077biological_processchaperone-mediated protein folding
E0070062cellular_componentextracellular exosome
E0090666biological_processscaRNA localization to Cajal body
E0140662molecular_functionATP-dependent protein folding chaperone
E1904851biological_processpositive regulation of establishment of protein localization to telomere
E1904871biological_processpositive regulation of protein localization to Cajal body
E1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
F0002199cellular_componentzona pellucida receptor complex
F0003723molecular_functionRNA binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005832cellular_componentchaperonin-containing T-complex
F0005856cellular_componentcytoskeleton
F0005874cellular_componentmicrotubule
F0006457biological_processprotein folding
F0007339biological_processbinding of sperm to zona pellucida
F0016887molecular_functionATP hydrolysis activity
F0032212biological_processpositive regulation of telomere maintenance via telomerase
F0042470cellular_componentmelanosome
F0042995cellular_componentcell projection
F0044183molecular_functionprotein folding chaperone
F0044297cellular_componentcell body
F0050821biological_processprotein stabilization
F0051082molecular_functionunfolded protein binding
F0051973biological_processpositive regulation of telomerase activity
F0061077biological_processchaperone-mediated protein folding
F0070062cellular_componentextracellular exosome
F0090666biological_processscaRNA localization to Cajal body
F0140662molecular_functionATP-dependent protein folding chaperone
F1904851biological_processpositive regulation of establishment of protein localization to telomere
F1904871biological_processpositive regulation of protein localization to Cajal body
F1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
G0000242cellular_componentpericentriolar material
G0000792cellular_componentheterochromatin
G0001669cellular_componentacrosomal vesicle
G0002199cellular_componentzona pellucida receptor complex
G0003723molecular_functionRNA binding
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005794cellular_componentGolgi apparatus
G0005813cellular_componentcentrosome
G0005815cellular_componentmicrotubule organizing center
G0005829cellular_componentcytosol
G0005832cellular_componentchaperonin-containing T-complex
G0005856cellular_componentcytoskeleton
G0005874cellular_componentmicrotubule
G0006457biological_processprotein folding
G0007021biological_processtubulin complex assembly
G0007339biological_processbinding of sperm to zona pellucida
G0016887molecular_functionATP hydrolysis activity
G0031625molecular_functionubiquitin protein ligase binding
G0032212biological_processpositive regulation of telomere maintenance via telomerase
G0044183molecular_functionprotein folding chaperone
G0044297cellular_componentcell body
G0050821biological_processprotein stabilization
G0051082molecular_functionunfolded protein binding
G0051973biological_processpositive regulation of telomerase activity
G0061077biological_processchaperone-mediated protein folding
G0070062cellular_componentextracellular exosome
G0090666biological_processscaRNA localization to Cajal body
G0140662molecular_functionATP-dependent protein folding chaperone
G1904851biological_processpositive regulation of establishment of protein localization to telomere
G1904871biological_processpositive regulation of protein localization to Cajal body
G1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
H0002199cellular_componentzona pellucida receptor complex
H0003723molecular_functionRNA binding
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005832cellular_componentchaperonin-containing T-complex
H0005856cellular_componentcytoskeleton
H0005874cellular_componentmicrotubule
H0006457biological_processprotein folding
H0007339biological_processbinding of sperm to zona pellucida
H0016887molecular_functionATP hydrolysis activity
H0032212biological_processpositive regulation of telomere maintenance via telomerase
H0044183molecular_functionprotein folding chaperone
H0044297cellular_componentcell body
H0050821biological_processprotein stabilization
H0051082molecular_functionunfolded protein binding
H0061077biological_processchaperone-mediated protein folding
H0070062cellular_componentextracellular exosome
H0140662molecular_functionATP-dependent protein folding chaperone
H1904851biological_processpositive regulation of establishment of protein localization to telomere
H1904871biological_processpositive regulation of protein localization to Cajal body
H1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
I0003723molecular_functionRNA binding
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005832cellular_componentchaperonin-containing T-complex
I0005874cellular_componentmicrotubule
I0006457biological_processprotein folding
I0016887molecular_functionATP hydrolysis activity
I0032212biological_processpositive regulation of telomere maintenance via telomerase
I0044183molecular_functionprotein folding chaperone
I0050821biological_processprotein stabilization
I0051082molecular_functionunfolded protein binding
I0061077biological_processchaperone-mediated protein folding
I0070062cellular_componentextracellular exosome
I0071987molecular_functionWD40-repeat domain binding
I0140662molecular_functionATP-dependent protein folding chaperone
I1904851biological_processpositive regulation of establishment of protein localization to telomere
I1904871biological_processpositive regulation of protein localization to Cajal body
I1904874biological_processpositive regulation of telomerase RNA localization to Cajal body
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues26
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGDGTTSVTVlAaellreaesl........IAKK
ChainResidueDetails
EVAL95-LYS120

site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. AIADTGANVVVT
ChainResidueDetails
BALA282-THR293

site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
AGLY140-GLY146

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
AMET1-ILE4

site_idPS00750
Number of Residues13
DetailsTCP1_1 Chaperonins TCP-1 signature 1. RTsLGPnGldKMM
ChainResidueDetails
DARG49-MET61
HARG38-LEU50
CARG37-ILE49
ELYS40-LEU52
BARG44-VAL56
FARG49-ILE61
GLYS33-LEU45
IARG35-LEU47

site_idPS00751
Number of Residues17
DetailsTCP1_2 Chaperonins TCP-1 signature 2. VTNDGATILsmMdVdHQ
ChainResidueDetails
DVAL70-GLN86
HMET59-PRO75
CILE58-PRO74
EVAL63-PRO79
BVAL65-PRO81
FILE70-PRO86
GILE54-PRO70
ILEU56-PRO72

site_idPS00995
Number of Residues9
DetailsTCP1_3 Chaperonins TCP-1 signature 3. QDdeIGDGT
ChainResidueDetails
DGLN98-THR106
HGLN87-THR95
CGLN86-THR94
EGLN91-THR99
BGLN93-THR101
FGLN98-THR106
GGLN82-THR90
IGLN84-THR92

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378
ChainResidueDetails
IALA2
ASER138
AGLY142
ATHR143
AGLY144
AASN204
AASN226

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P80317
ChainResidueDetails
ILYS5
ILYS287

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ILYS199
ILYS365
ILYS377
ILYS388

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER205
GLYS400
FLYS319
FLYS326
DLYS265
DLYS275
DLYS279
DLYS392

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ILYS251
BLYS400
BLYS466

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
HTYR247

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
HSER252
BLYS254
BLYS260

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
HTHR430
HTHR459

site_idSWS_FT_FI9
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
HLYS15
HLYS248
HLYS249

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211
ChainResidueDetails
BLYS534
HLYS381

site_idSWS_FT_FI11
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
ALYS58

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS324

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PDB entries from 2024-07-24

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