Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7TTI

Human KCC1 bound with VU0463271 In an outward-open state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006884	biological_process	cell volume homeostasis
A	0007268	biological_process	chemical synaptic transmission
A	0015293	molecular_function	symporter activity
A	0015377	molecular_function	chloride:monoatomic cation symporter activity
A	0015379	molecular_function	potassium:chloride symporter activity
A	0016020	cellular_component	membrane
A	0019901	molecular_function	protein kinase binding
A	0022857	molecular_function	transmembrane transporter activity
A	0045202	cellular_component	synapse
A	0055064	biological_process	chloride ion homeostasis
A	0055075	biological_process	potassium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0120283	molecular_function	protein serine/threonine kinase binding
A	1902476	biological_process	chloride transmembrane transport
A	1990573	biological_process	potassium ion import across plasma membrane
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005765	cellular_component	lysosomal membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006884	biological_process	cell volume homeostasis
B	0007268	biological_process	chemical synaptic transmission
B	0015293	molecular_function	symporter activity
B	0015377	molecular_function	chloride:monoatomic cation symporter activity
B	0015379	molecular_function	potassium:chloride symporter activity
B	0016020	cellular_component	membrane
B	0019901	molecular_function	protein kinase binding
B	0022857	molecular_function	transmembrane transporter activity
B	0045202	cellular_component	synapse
B	0055064	biological_process	chloride ion homeostasis
B	0055075	biological_process	potassium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	0120283	molecular_function	protein serine/threonine kinase binding
B	1902476	biological_process	chloride transmembrane transport
B	1990573	biological_process	potassium ion import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Transmembrane: {"description":"Discontinuously helical; Name=1","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	360
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	134
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34031912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35759661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31649201","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)