7TS1
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(4,4-difluoropiperidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004517 | molecular_function | nitric-oxide synthase activity |
A | 0006809 | biological_process | nitric oxide biosynthetic process |
B | 0004517 | molecular_function | nitric-oxide synthase activity |
B | 0006809 | biological_process | nitric oxide biosynthetic process |
C | 0004517 | molecular_function | nitric-oxide synthase activity |
C | 0006809 | biological_process | nitric oxide biosynthetic process |
D | 0004517 | molecular_function | nitric-oxide synthase activity |
D | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PROSITE/UniProt
site_id | PS60001 |
Number of Residues | 8 |
Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
Chain | Residue | Details |
A | ARG419-TRP426 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 36 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N |
Chain | Residue | Details |
A | SER339 | |
B | SER339 | |
B | GLN483 | |
B | TRP592 | |
B | TYR593 | |
B | GLU597 | |
B | VAL682 | |
B | TRP683 | |
B | PHE696 | |
B | TYR711 | |
C | SER339 | |
A | GLN483 | |
C | GLN483 | |
C | TRP592 | |
C | TYR593 | |
C | GLU597 | |
C | VAL682 | |
C | TRP683 | |
C | PHE696 | |
C | TYR711 | |
D | SER339 | |
D | GLN483 | |
A | TRP592 | |
D | TRP592 | |
D | TYR593 | |
D | GLU597 | |
D | VAL682 | |
D | TRP683 | |
D | PHE696 | |
D | TYR711 | |
A | TYR593 | |
A | GLU597 | |
A | VAL682 | |
A | TRP683 | |
A | PHE696 | |
A | TYR711 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N |
Chain | Residue | Details |
A | CYS420 | |
B | CYS420 | |
C | CYS420 | |
D | CYS420 |