7TN4

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 3-diphosphoinositol 1,2,4,5-tetrakisphosphate (3-PP-IP4), Mg and Fluoride ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000298	molecular_function	endopolyphosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007267	biological_process	cell-cell signaling
A	0008270	molecular_function	zinc ion binding
A	0008486	molecular_function	diphosphoinositol-polyphosphate diphosphatase activity
A	0015961	biological_process	diadenosine polyphosphate catabolic process
A	0016462	molecular_function	pyrophosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0034431	molecular_function	bis(5'-adenosyl)-hexaphosphatase activity
A	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
A	0046872	molecular_function	metal ion binding
A	0052840	molecular_function	inositol diphosphate tetrakisphosphate diphosphatase activity
A	0052842	molecular_function	inositol diphosphate pentakisphosphate diphosphatase activity
A	0052845	molecular_function	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
A	0052848	molecular_function	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
A	0071543	biological_process	diphosphoinositol polyphosphate metabolic process
A	0071544	biological_process	diphosphoinositol polyphosphate catabolic process
A	0110154	biological_process	RNA decapping
A	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
A	1901907	biological_process	diadenosine pentaphosphate catabolic process
A	1901909	biological_process	diadenosine hexaphosphate catabolic process
A	1901911	biological_process	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG

Chain	Residue	Details
A	GLY51-GLY72

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305

Chain	Residue	Details
A	GLU69

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2FVV, ECO:0007744|PDB:2Q9P

Chain	Residue	Details
A	LYS18
A	SER39
A	ARG89
A	LYS133
A	ARG10

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2Q9P

Chain	Residue	Details
A	GLU66
A	GLU70
A	ARG115
A	GLY50

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1

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