Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7TMP

V1 complex lacking subunit C from Saccharomyces cerevisiae, State 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0046034	biological_process	ATP metabolic process
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
B	0000329	cellular_component	fungal-type vacuole membrane
B	0000425	biological_process	pexophagy
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005774	cellular_component	vacuolar membrane
B	0006811	biological_process	monoatomic ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0007035	biological_process	vacuolar acidification
B	0010494	cellular_component	cytoplasmic stress granule
B	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
B	0033176	cellular_component	proton-transporting V-type ATPase complex
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0045121	cellular_component	membrane raft
B	0046034	biological_process	ATP metabolic process
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	0048388	biological_process	endosomal lumen acidification
B	0055085	biological_process	transmembrane transport
B	0061795	biological_process	Golgi lumen acidification
B	1902600	biological_process	proton transmembrane transport
B	1902906	biological_process	proteasome storage granule assembly
B	1990816	cellular_component	vacuole-mitochondrion membrane contact site
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0046034	biological_process	ATP metabolic process
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0000329	cellular_component	fungal-type vacuole membrane
D	0000425	biological_process	pexophagy
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005774	cellular_component	vacuolar membrane
D	0006811	biological_process	monoatomic ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0007035	biological_process	vacuolar acidification
D	0010494	cellular_component	cytoplasmic stress granule
D	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
D	0033176	cellular_component	proton-transporting V-type ATPase complex
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0045121	cellular_component	membrane raft
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0048388	biological_process	endosomal lumen acidification
D	0055085	biological_process	transmembrane transport
D	0061795	biological_process	Golgi lumen acidification
D	1902600	biological_process	proton transmembrane transport
D	1902906	biological_process	proteasome storage granule assembly
D	1990816	cellular_component	vacuole-mitochondrion membrane contact site
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0000329	cellular_component	fungal-type vacuole membrane
F	0000425	biological_process	pexophagy
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005774	cellular_component	vacuolar membrane
F	0006811	biological_process	monoatomic ion transport
F	0006874	biological_process	intracellular calcium ion homeostasis
F	0007035	biological_process	vacuolar acidification
F	0010494	cellular_component	cytoplasmic stress granule
F	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
F	0033176	cellular_component	proton-transporting V-type ATPase complex
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0045121	cellular_component	membrane raft
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0048388	biological_process	endosomal lumen acidification
F	0055085	biological_process	transmembrane transport
F	0061795	biological_process	Golgi lumen acidification
F	1902600	biological_process	proton transmembrane transport
F	1902906	biological_process	proteasome storage granule assembly
F	1990816	cellular_component	vacuole-mitochondrion membrane contact site
G	0000139	cellular_component	Golgi membrane
G	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005515	molecular_function	protein binding
G	0005774	cellular_component	vacuolar membrane
G	0006811	biological_process	monoatomic ion transport
G	0007035	biological_process	vacuolar acidification
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
G	0045121	cellular_component	membrane raft
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0048388	biological_process	endosomal lumen acidification
G	0061795	biological_process	Golgi lumen acidification
G	1902600	biological_process	proton transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
H	0000329	cellular_component	fungal-type vacuole membrane
H	0005515	molecular_function	protein binding
H	0005774	cellular_component	vacuolar membrane
H	0006811	biological_process	monoatomic ion transport
H	0007035	biological_process	vacuolar acidification
H	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
H	0016887	molecular_function	ATP hydrolysis activity
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0048388	biological_process	endosomal lumen acidification
H	0061795	biological_process	Golgi lumen acidification
H	1902600	biological_process	proton transmembrane transport
I	0000139	cellular_component	Golgi membrane
I	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
I	0000329	cellular_component	fungal-type vacuole membrane
I	0005515	molecular_function	protein binding
I	0005774	cellular_component	vacuolar membrane
I	0006811	biological_process	monoatomic ion transport
I	0007035	biological_process	vacuolar acidification
I	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
I	0033176	cellular_component	proton-transporting V-type ATPase complex
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0045121	cellular_component	membrane raft
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0048388	biological_process	endosomal lumen acidification
I	0061795	biological_process	Golgi lumen acidification
I	1902600	biological_process	proton transmembrane transport
J	0000139	cellular_component	Golgi membrane
J	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
J	0000329	cellular_component	fungal-type vacuole membrane
J	0005515	molecular_function	protein binding
J	0005774	cellular_component	vacuolar membrane
J	0006811	biological_process	monoatomic ion transport
J	0007035	biological_process	vacuolar acidification
J	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
J	0016887	molecular_function	ATP hydrolysis activity
J	0033176	cellular_component	proton-transporting V-type ATPase complex
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0048388	biological_process	endosomal lumen acidification
J	0061795	biological_process	Golgi lumen acidification
J	1902600	biological_process	proton transmembrane transport
K	0000139	cellular_component	Golgi membrane
K	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
K	0000329	cellular_component	fungal-type vacuole membrane
K	0005515	molecular_function	protein binding
K	0005774	cellular_component	vacuolar membrane
K	0006811	biological_process	monoatomic ion transport
K	0007035	biological_process	vacuolar acidification
K	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
K	0033176	cellular_component	proton-transporting V-type ATPase complex
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0045121	cellular_component	membrane raft
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	0048388	biological_process	endosomal lumen acidification
K	0061795	biological_process	Golgi lumen acidification
K	1902600	biological_process	proton transmembrane transport
L	0000139	cellular_component	Golgi membrane
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0000329	cellular_component	fungal-type vacuole membrane
L	0005515	molecular_function	protein binding
L	0005774	cellular_component	vacuolar membrane
L	0006811	biological_process	monoatomic ion transport
L	0007035	biological_process	vacuolar acidification
L	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
L	0016887	molecular_function	ATP hydrolysis activity
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0048388	biological_process	endosomal lumen acidification
L	0061795	biological_process	Golgi lumen acidification
L	1902600	biological_process	proton transmembrane transport
M	0000139	cellular_component	Golgi membrane
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0000329	cellular_component	fungal-type vacuole membrane
M	0005515	molecular_function	protein binding
M	0005774	cellular_component	vacuolar membrane
M	0006811	biological_process	monoatomic ion transport
M	0007035	biological_process	vacuolar acidification
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0045121	cellular_component	membrane raft
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0048388	biological_process	endosomal lumen acidification
M	0061795	biological_process	Golgi lumen acidification
M	1902600	biological_process	proton transmembrane transport
N	0000139	cellular_component	Golgi membrane
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005515	molecular_function	protein binding
N	0005774	cellular_component	vacuolar membrane
N	0006811	biological_process	monoatomic ion transport
N	0007035	biological_process	vacuolar acidification
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
N	0034220	biological_process	monoatomic ion transmembrane transport
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0048388	biological_process	endosomal lumen acidification
N	0061795	biological_process	Golgi lumen acidification
N	1902600	biological_process	proton transmembrane transport
P	0000139	cellular_component	Golgi membrane
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0000329	cellular_component	fungal-type vacuole membrane
P	0005515	molecular_function	protein binding
P	0005774	cellular_component	vacuolar membrane
P	0006811	biological_process	monoatomic ion transport
P	0007035	biological_process	vacuolar acidification
P	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
P	0033176	cellular_component	proton-transporting V-type ATPase complex
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	0048388	biological_process	endosomal lumen acidification
P	0061795	biological_process	Golgi lumen acidification
P	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPINVLPSLS

Chain	Residue	Details
B	PRO371-SER380
A	PRO452-SER461

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P38606","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21281","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	19
Details	Region: {"description":"Interaction with VMA10","evidences":[{"source":"PubMed","id":"15751969","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	30
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 508

Chain	Residue	Details
A	CYS283	covalent catalysis

site_id	MCSA2
Number of Residues	1
Details	M-CSA 508

Chain	Residue	Details
C	CYS283	covalent catalysis

site_id	MCSA3
Number of Residues	1
Details	M-CSA 508

Chain	Residue	Details
E	CYS283	covalent catalysis

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)