7TKU

Structure of the yeast clamp loader (Replication Factor C RFC) bound to the open sliding clamp (Proliferating Cell Nuclear Antigen PCNA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000278	biological_process	mitotic cell cycle
A	0003677	molecular_function	DNA binding
A	0003689	molecular_function	DNA clamp loader activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005663	cellular_component	DNA replication factor C complex
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0006272	biological_process	leading strand elongation
A	0006281	biological_process	DNA repair
A	0006298	biological_process	mismatch repair
A	0016887	molecular_function	ATP hydrolysis activity
A	0051301	biological_process	cell division
B	0000077	biological_process	DNA damage checkpoint signaling
B	0003677	molecular_function	DNA binding
B	0003689	molecular_function	DNA clamp loader activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005663	cellular_component	DNA replication factor C complex
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006272	biological_process	leading strand elongation
B	0006281	biological_process	DNA repair
B	0007062	biological_process	sister chromatid cohesion
B	0007064	biological_process	mitotic sister chromatid cohesion
B	0016887	molecular_function	ATP hydrolysis activity
B	0031389	cellular_component	Rad17 RFC-like complex
B	0031390	cellular_component	Ctf18 RFC-like complex
B	0031391	cellular_component	Elg1 RFC-like complex
B	0090618	biological_process	DNA clamp unloading
C	0000077	biological_process	DNA damage checkpoint signaling
C	0003677	molecular_function	DNA binding
C	0003689	molecular_function	DNA clamp loader activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005663	cellular_component	DNA replication factor C complex
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006272	biological_process	leading strand elongation
C	0006281	biological_process	DNA repair
C	0006298	biological_process	mismatch repair
C	0007064	biological_process	mitotic sister chromatid cohesion
C	0016887	molecular_function	ATP hydrolysis activity
C	0031389	cellular_component	Rad17 RFC-like complex
C	0031390	cellular_component	Ctf18 RFC-like complex
C	0031391	cellular_component	Elg1 RFC-like complex
C	0090618	biological_process	DNA clamp unloading
D	0000076	biological_process	DNA replication checkpoint signaling
D	0000077	biological_process	DNA damage checkpoint signaling
D	0003677	molecular_function	DNA binding
D	0003689	molecular_function	DNA clamp loader activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005663	cellular_component	DNA replication factor C complex
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006271	biological_process	DNA strand elongation involved in DNA replication
D	0006272	biological_process	leading strand elongation
D	0006281	biological_process	DNA repair
D	0006298	biological_process	mismatch repair
D	0007062	biological_process	sister chromatid cohesion
D	0007064	biological_process	mitotic sister chromatid cohesion
D	0016887	molecular_function	ATP hydrolysis activity
D	0031389	cellular_component	Rad17 RFC-like complex
D	0031390	cellular_component	Ctf18 RFC-like complex
D	0031391	cellular_component	Elg1 RFC-like complex
D	0090618	biological_process	DNA clamp unloading
E	0000077	biological_process	DNA damage checkpoint signaling
E	0003677	molecular_function	DNA binding
E	0003689	molecular_function	DNA clamp loader activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005663	cellular_component	DNA replication factor C complex
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006271	biological_process	DNA strand elongation involved in DNA replication
E	0006272	biological_process	leading strand elongation
E	0006281	biological_process	DNA repair
E	0007062	biological_process	sister chromatid cohesion
E	0007064	biological_process	mitotic sister chromatid cohesion
E	0016887	molecular_function	ATP hydrolysis activity
E	0031389	cellular_component	Rad17 RFC-like complex
E	0031390	cellular_component	Ctf18 RFC-like complex
E	0031391	cellular_component	Elg1 RFC-like complex
E	0090618	biological_process	DNA clamp unloading
F	0000278	biological_process	mitotic cell cycle
F	0000710	biological_process	meiotic mismatch repair
F	0000781	cellular_component	chromosome, telomeric region
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005657	cellular_component	replication fork
F	0006260	biological_process	DNA replication
F	0006272	biological_process	leading strand elongation
F	0006273	biological_process	lagging strand elongation
F	0006275	biological_process	regulation of DNA replication
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006298	biological_process	mismatch repair
F	0006301	biological_process	postreplication repair
F	0007064	biological_process	mitotic sister chromatid cohesion
F	0019985	biological_process	translesion synthesis
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0030466	biological_process	silent mating-type cassette heterochromatin formation
F	0031509	biological_process	subtelomeric heterochromatin formation
F	0034087	biological_process	establishment of mitotic sister chromatid cohesion
F	0035753	biological_process	maintenance of DNA trinucleotide repeats
F	0042802	molecular_function	identical protein binding
F	0043626	cellular_component	PCNA complex
F	0045739	biological_process	positive regulation of DNA repair
F	0045740	biological_process	positive regulation of DNA replication
F	0051054	biological_process	positive regulation of DNA metabolic process
F	0070987	biological_process	error-free translesion synthesis
G	0000278	biological_process	mitotic cell cycle
G	0000710	biological_process	meiotic mismatch repair
G	0000781	cellular_component	chromosome, telomeric region
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005657	cellular_component	replication fork
G	0006260	biological_process	DNA replication
G	0006272	biological_process	leading strand elongation
G	0006273	biological_process	lagging strand elongation
G	0006275	biological_process	regulation of DNA replication
G	0006281	biological_process	DNA repair
G	0006289	biological_process	nucleotide-excision repair
G	0006298	biological_process	mismatch repair
G	0006301	biological_process	postreplication repair
G	0007064	biological_process	mitotic sister chromatid cohesion
G	0019985	biological_process	translesion synthesis
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0030466	biological_process	silent mating-type cassette heterochromatin formation
G	0031509	biological_process	subtelomeric heterochromatin formation
G	0034087	biological_process	establishment of mitotic sister chromatid cohesion
G	0035753	biological_process	maintenance of DNA trinucleotide repeats
G	0042802	molecular_function	identical protein binding
G	0043626	cellular_component	PCNA complex
G	0045739	biological_process	positive regulation of DNA repair
G	0045740	biological_process	positive regulation of DNA replication
G	0051054	biological_process	positive regulation of DNA metabolic process
G	0070987	biological_process	error-free translesion synthesis
H	0000278	biological_process	mitotic cell cycle
H	0000710	biological_process	meiotic mismatch repair
H	0000781	cellular_component	chromosome, telomeric region
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005657	cellular_component	replication fork
H	0006260	biological_process	DNA replication
H	0006272	biological_process	leading strand elongation
H	0006273	biological_process	lagging strand elongation
H	0006275	biological_process	regulation of DNA replication
H	0006281	biological_process	DNA repair
H	0006289	biological_process	nucleotide-excision repair
H	0006298	biological_process	mismatch repair
H	0006301	biological_process	postreplication repair
H	0007064	biological_process	mitotic sister chromatid cohesion
H	0019985	biological_process	translesion synthesis
H	0030337	molecular_function	DNA polymerase processivity factor activity
H	0030466	biological_process	silent mating-type cassette heterochromatin formation
H	0031509	biological_process	subtelomeric heterochromatin formation
H	0034087	biological_process	establishment of mitotic sister chromatid cohesion
H	0035753	biological_process	maintenance of DNA trinucleotide repeats
H	0042802	molecular_function	identical protein binding
H	0043626	cellular_component	PCNA complex
H	0045739	biological_process	positive regulation of DNA repair
H	0045740	biological_process	positive regulation of DNA replication
H	0051054	biological_process	positive regulation of DNA metabolic process
H	0070987	biological_process	error-free translesion synthesis

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDHpvtLgmdLtSLsKIL

Chain	Residue	Details
F	ARG61-LEU79

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site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GIiAqAVDdSRVlLVsLeIgveaF

Chain	Residue	Details
F	GLY34-PHE57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	DNA_BIND: DNA_BIND => ECO:0000255

Chain	Residue	Details
F	ARG61-ARG80
G	ARG61-ARG80
H	ARG61-ARG80
E	ARG231
D	ARG229
C	ARG206

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site_id	SWS_FT_FI2
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15166219

Chain	Residue	Details
F	LYS127
G	LYS127
H	LYS127

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site_id	SWS_FT_FI3
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:12226657

Chain	Residue	Details
A	SER40
F	LYS164
G	LYS164
H	LYS164

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	THR63

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