7TI1

Structure of AmpC bound to RPX-7063 at 2.0A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030288	cellular_component	outer membrane-bounded periplasmic space

Functional Information from PROSITE/UniProt

site_id	PS00336
Number of Residues	8
Details	BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSISK

Chain	Residue	Details
A	PHE80-LYS87

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Acyl-ester intermediate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 257

Chain	Residue	Details
A	SER84	electrostatic stabiliser, hydrogen bond donor
A	LYS87	electrostatic stabiliser, hydrogen bond donor, increase acidity
A	TYR170	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU292	electrostatic stabiliser, hydrogen bond acceptor
A	LYS335	electrostatic stabiliser, hydrogen bond donor, increase acidity
A	SER338	electrostatic stabiliser, hydrogen bond donor

---