7TI1

Structure of AmpC bound to RPX-7063 at 2.0A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030288	cellular_component	outer membrane-bounded periplasmic space

Functional Information from PROSITE/UniProt

site_id	PS00336
Number of Residues	8
Details	BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSISK

Chain	Residue	Details
A	PHE80-LYS87

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate

Chain	Residue	Details
A	SER84

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	TYR170

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS335

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 257

Chain	Residue	Details
A	SER84	electrostatic stabiliser, hydrogen bond donor
A	LYS87	electrostatic stabiliser, hydrogen bond donor, increase acidity
A	TYR170	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU292	electrostatic stabiliser, hydrogen bond acceptor
A	LYS335	electrostatic stabiliser, hydrogen bond donor, increase acidity
A	SER338	electrostatic stabiliser, hydrogen bond donor

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