7THU
Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004129 | molecular_function | cytochrome-c oxidase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0006119 | biological_process | oxidative phosphorylation |
A | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
A | 0009060 | biological_process | aerobic respiration |
A | 0015990 | biological_process | electron transport coupled proton transport |
A | 0016020 | cellular_component | membrane |
A | 0020037 | molecular_function | heme binding |
A | 0045277 | cellular_component | respiratory chain complex IV |
A | 0046872 | molecular_function | metal ion binding |
B | 0004129 | molecular_function | cytochrome-c oxidase activity |
B | 0005507 | molecular_function | copper ion binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0022900 | biological_process | electron transport chain |
B | 0042773 | biological_process | ATP synthesis coupled electron transport |
B | 0045277 | cellular_component | respiratory chain complex IV |
B | 0046872 | molecular_function | metal ion binding |
B | 1902600 | biological_process | proton transmembrane transport |
C | 0004129 | molecular_function | cytochrome-c oxidase activity |
C | 0005739 | cellular_component | mitochondrion |
C | 0005743 | cellular_component | mitochondrial inner membrane |
C | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
C | 0008535 | biological_process | respiratory chain complex IV assembly |
C | 0009055 | molecular_function | electron transfer activity |
C | 0016020 | cellular_component | membrane |
C | 0019646 | biological_process | aerobic electron transport chain |
C | 0022904 | biological_process | respiratory electron transport chain |
C | 0045277 | cellular_component | respiratory chain complex IV |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
D | 0045277 | cellular_component | respiratory chain complex IV |
E | 0005743 | cellular_component | mitochondrial inner membrane |
E | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
E | 0045277 | cellular_component | respiratory chain complex IV |
F | 0005740 | cellular_component | mitochondrial envelope |
F | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
F | 0045277 | cellular_component | respiratory chain complex IV |
G | 0005743 | cellular_component | mitochondrial inner membrane |
H | 0005739 | cellular_component | mitochondrion |
H | 0005743 | cellular_component | mitochondrial inner membrane |
H | 0006119 | biological_process | oxidative phosphorylation |
H | 0045277 | cellular_component | respiratory chain complex IV |
I | 0005739 | cellular_component | mitochondrion |
I | 0005743 | cellular_component | mitochondrial inner membrane |
I | 0006119 | biological_process | oxidative phosphorylation |
I | 0045277 | cellular_component | respiratory chain complex IV |
J | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
J | 0045277 | cellular_component | respiratory chain complex IV |
K | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
L | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
L | 0045277 | cellular_component | respiratory chain complex IV |
M | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
M | 0045277 | cellular_component | respiratory chain complex IV |
N | 0004129 | molecular_function | cytochrome-c oxidase activity |
N | 0005739 | cellular_component | mitochondrion |
N | 0005743 | cellular_component | mitochondrial inner membrane |
N | 0006119 | biological_process | oxidative phosphorylation |
N | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
N | 0009060 | biological_process | aerobic respiration |
N | 0015990 | biological_process | electron transport coupled proton transport |
N | 0016020 | cellular_component | membrane |
N | 0020037 | molecular_function | heme binding |
N | 0045277 | cellular_component | respiratory chain complex IV |
N | 0046872 | molecular_function | metal ion binding |
O | 0004129 | molecular_function | cytochrome-c oxidase activity |
O | 0005507 | molecular_function | copper ion binding |
O | 0005739 | cellular_component | mitochondrion |
O | 0005743 | cellular_component | mitochondrial inner membrane |
O | 0016020 | cellular_component | membrane |
O | 0016491 | molecular_function | oxidoreductase activity |
O | 0022900 | biological_process | electron transport chain |
O | 0042773 | biological_process | ATP synthesis coupled electron transport |
O | 0045277 | cellular_component | respiratory chain complex IV |
O | 0046872 | molecular_function | metal ion binding |
O | 1902600 | biological_process | proton transmembrane transport |
P | 0004129 | molecular_function | cytochrome-c oxidase activity |
P | 0005739 | cellular_component | mitochondrion |
P | 0005743 | cellular_component | mitochondrial inner membrane |
P | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
P | 0008535 | biological_process | respiratory chain complex IV assembly |
P | 0009055 | molecular_function | electron transfer activity |
P | 0016020 | cellular_component | membrane |
P | 0019646 | biological_process | aerobic electron transport chain |
P | 0022904 | biological_process | respiratory electron transport chain |
P | 0045277 | cellular_component | respiratory chain complex IV |
P | 1902600 | biological_process | proton transmembrane transport |
Q | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
Q | 0045277 | cellular_component | respiratory chain complex IV |
R | 0005743 | cellular_component | mitochondrial inner membrane |
R | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
R | 0045277 | cellular_component | respiratory chain complex IV |
S | 0005740 | cellular_component | mitochondrial envelope |
S | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
S | 0045277 | cellular_component | respiratory chain complex IV |
T | 0005743 | cellular_component | mitochondrial inner membrane |
U | 0005739 | cellular_component | mitochondrion |
U | 0005743 | cellular_component | mitochondrial inner membrane |
U | 0006119 | biological_process | oxidative phosphorylation |
U | 0045277 | cellular_component | respiratory chain complex IV |
V | 0005739 | cellular_component | mitochondrion |
V | 0005743 | cellular_component | mitochondrial inner membrane |
V | 0006119 | biological_process | oxidative phosphorylation |
V | 0045277 | cellular_component | respiratory chain complex IV |
W | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
W | 0045277 | cellular_component | respiratory chain complex IV |
X | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
Y | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
Y | 0045277 | cellular_component | respiratory chain complex IV |
Z | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
Z | 0045277 | cellular_component | respiratory chain complex IV |
Functional Information from PROSITE/UniProt
site_id | PS00077 |
Number of Residues | 56 |
Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH |
Chain | Residue | Details |
A | TRP236-HIS291 |
site_id | PS00078 |
Number of Residues | 49 |
Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM |
Chain | Residue | Details |
B | VAL159-MET207 |
site_id | PS00848 |
Number of Residues | 23 |
Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL |
Chain | Residue | Details |
F | VAL69-LEU91 |
site_id | PS01329 |
Number of Residues | 18 |
Details | COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN |
Chain | Residue | Details |
G | ILE55-ASN72 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 20 |
Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
M | ILE1-SER11 | |
N | SER262-GLY269 | |
N | SER401-ASN406 | |
N | LYS479-LYS514 | |
Z | ILE1-SER11 | |
F | CYS82 | |
F | CYS85 | |
S | CYS60 | |
S | CYS62 | |
S | CYS82 | |
S | CYS85 | |
N | MET171-PRO182 |
site_id | SWS_FT_FI2 |
Number of Residues | 46 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
M | PRO12-TYR35 | |
Z | PRO12-TYR35 | |
F | LYS90 | |
S | LYS37 | |
S | LYS55 | |
S | LYS90 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
M | HIS36-ALA46 | |
Z | HIS36-ALA46 | |
C | ALA184-ASP190 | |
C | TYR257-SER261 | |
P | PHE35-MET40 | |
P | LEU106-GLU128 | |
P | ALA184-ASP190 | |
P | TYR257-SER261 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P17665 |
Chain | Residue | Details |
L | LYS9 | |
Y | LYS9 | |
Q | LYS7 | |
Q | LYS38 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P13073 |
Chain | Residue | Details |
D | LYS31 | |
O | CYS200 | |
O | HIS204 | |
O | MET207 | |
Q | LYS31 | |
B | GLU198 | |
B | CYS200 | |
B | HIS204 | |
B | MET207 | |
O | HIS161 | |
O | CYS196 | |
O | GLU198 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10888 |
Chain | Residue | Details |
D | SER34 | |
D | SER36 | |
Q | SER34 | |
Q | SER36 | |
N | ARG213-ASP227 | |
N | VAL287-ASP298 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19783 |
Chain | Residue | Details |
D | LYS45 | |
Q | LYS45 |
site_id | SWS_FT_FI8 |
Number of Residues | 64 |
Details | TRANSMEM: Helical; Name=VI => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
C | GLY191-LEU223 | |
P | GLY191-LEU223 |
site_id | SWS_FT_FI9 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
C | PHE233-ILE256 | |
P | PHE233-ILE256 |
site_id | SWS_FT_FI10 |
Number of Residues | 32 |
Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | TYR270-ILE286 | |
N | TYR270-ILE286 |
site_id | SWS_FT_FI11 |
Number of Residues | 56 |
Details | TRANSMEM: Helical; Name=VIII => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | VAL299-LEU327 | |
N | VAL299-LEU327 |
site_id | SWS_FT_FI12 |
Number of Residues | 14 |
Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | HIS328-SER335 | |
N | HIS328-SER335 |
site_id | SWS_FT_FI13 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=IX => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | PRO336-VAL357 | |
N | PRO336-VAL357 |
site_id | SWS_FT_FI14 |
Number of Residues | 48 |
Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | LEU358-THR370 | |
A | SER434-ALA446 | |
N | LEU358-THR370 | |
N | SER434-ALA446 |
site_id | SWS_FT_FI15 |
Number of Residues | 58 |
Details | TRANSMEM: Helical; Name=X => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | TYR371-PHE400 | |
N | TYR371-PHE400 |
site_id | SWS_FT_FI16 |
Number of Residues | 52 |
Details | TRANSMEM: Helical; Name=XI => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | ASP407-LEU433 | |
N | ASP407-LEU433 |
site_id | SWS_FT_FI17 |
Number of Residues | 62 |
Details | TRANSMEM: Helical; Name=XII => ECO:0000269|PubMed:27605664 |
Chain | Residue | Details |
A | TYR447-SER478 | |
N | TYR447-SER478 |
site_id | SWS_FT_FI18 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 |
Chain | Residue | Details |
A | GLU40 | |
A | GLY45 | |
A | SER441 | |
N | GLU40 | |
N | GLY45 | |
N | SER441 |
site_id | SWS_FT_FI19 |
Number of Residues | 6 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
Chain | Residue | Details |
A | HIS61 | |
A | HIS376 | |
A | HIS378 | |
N | HIS61 | |
N | HIS376 | |
N | HIS378 |
site_id | SWS_FT_FI20 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
Chain | Residue | Details |
A | HIS240 | |
N | ASP369 | |
A | HIS290 | |
A | HIS291 | |
A | HIS368 | |
A | ASP369 | |
N | HIS240 | |
N | HIS290 | |
N | HIS291 | |
N | HIS368 |
site_id | SWS_FT_FI21 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305 |
Chain | Residue | Details |
A | TYR244 | |
N | TYR244 |
site_id | SWS_FT_FI22 |
Number of Residues | 2 |
Details | MOD_RES: N-formylmethionine => ECO:0000269|PubMed:2165784 |
Chain | Residue | Details |
A | FME1 | |
N | FME1 |
site_id | SWS_FT_FI23 |
Number of Residues | 4 |
Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009 |
Chain | Residue | Details |
A | HIS240 | |
A | TYR244 | |
N | HIS240 | |
N | TYR244 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 14 |
Details | M-CSA 124 |
Chain | Residue | Details |
A | HIS61 | metal ligand |
A | HIS290 | metal ligand |
A | HIS291 | metal ligand, proton acceptor, proton donor |
A | THR316 | proton acceptor, proton donor, proton relay |
A | LYS319 | proton acceptor, proton donor, proton relay |
A | ARG438 | proton acceptor, proton donor, proton relay |
A | ASP91 | proton acceptor, proton donor, proton relay |
A | TRP126 | proton acceptor, proton donor, proton relay |
A | SER156 | proton acceptor, proton donor, proton relay |
A | SER157 | proton acceptor, proton donor, proton relay |
A | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
A | GLU242 | proton acceptor, proton donor, proton relay |
A | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
A | SER255 | proton acceptor, proton donor, proton relay |
site_id | MCSA2 |
Number of Residues | 14 |
Details | M-CSA 124 |
Chain | Residue | Details |
N | HIS61 | metal ligand |
N | HIS290 | metal ligand |
N | HIS291 | metal ligand, proton acceptor, proton donor |
N | THR316 | proton acceptor, proton donor, proton relay |
N | LYS319 | proton acceptor, proton donor, proton relay |
N | ARG438 | proton acceptor, proton donor, proton relay |
N | ASP91 | proton acceptor, proton donor, proton relay |
N | TRP126 | proton acceptor, proton donor, proton relay |
N | SER156 | proton acceptor, proton donor, proton relay |
N | SER157 | proton acceptor, proton donor, proton relay |
N | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
N | GLU242 | proton acceptor, proton donor, proton relay |
N | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
N | SER255 | proton acceptor, proton donor, proton relay |