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7TDO

Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state

Functional Information from GO Data
ChainGOidnamespacecontents
A0004176molecular_functionATP-dependent peptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0030163biological_processprotein catabolic process
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
B0004176molecular_functionATP-dependent peptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0030163biological_processprotein catabolic process
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
C0004176molecular_functionATP-dependent peptidase activity
C0004222molecular_functionmetalloendopeptidase activity
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0008237molecular_functionmetallopeptidase activity
C0008270molecular_functionzinc ion binding
C0016020cellular_componentmembrane
C0016887molecular_functionATP hydrolysis activity
C0030163biological_processprotein catabolic process
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
D0004176molecular_functionATP-dependent peptidase activity
D0004222molecular_functionmetalloendopeptidase activity
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0008233molecular_functionpeptidase activity
D0008237molecular_functionmetallopeptidase activity
D0008270molecular_functionzinc ion binding
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0030163biological_processprotein catabolic process
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
E0004176molecular_functionATP-dependent peptidase activity
E0004222molecular_functionmetalloendopeptidase activity
E0005524molecular_functionATP binding
E0005886cellular_componentplasma membrane
E0006508biological_processproteolysis
E0008233molecular_functionpeptidase activity
E0008237molecular_functionmetallopeptidase activity
E0008270molecular_functionzinc ion binding
E0016020cellular_componentmembrane
E0016887molecular_functionATP hydrolysis activity
E0030163biological_processprotein catabolic process
E0042802molecular_functionidentical protein binding
E0046872molecular_functionmetal ion binding
F0004176molecular_functionATP-dependent peptidase activity
F0004222molecular_functionmetalloendopeptidase activity
F0005524molecular_functionATP binding
F0005886cellular_componentplasma membrane
F0006508biological_processproteolysis
F0008233molecular_functionpeptidase activity
F0008237molecular_functionmetallopeptidase activity
F0008270molecular_functionzinc ion binding
F0016020cellular_componentmembrane
F0016887molecular_functionATP hydrolysis activity
F0030163biological_processprotein catabolic process
F0042802molecular_functionidentical protein binding
F0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IiVMaATNrpdiLDpALl.R
ChainResidueDetails
AILE300-ARG318

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2910
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255|HAMAP-Rule:MF_01458
ChainResidueDetails
AMET1-ASN5
EMET129-GLU610
FMET1-ASN5
FMET129-GLU610
AMET129-GLU610
BMET1-ASN5
BMET129-GLU610
CMET1-ASN5
CMET129-GLU610
DMET1-ASN5
DMET129-GLU610
EMET1-ASN5

site_idSWS_FT_FI2
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_01458
ChainResidueDetails
AILE6-PHE26
ETRP108-ILE128
FILE6-PHE26
FTRP108-ILE128
ATRP108-ILE128
BILE6-PHE26
BTRP108-ILE128
CILE6-PHE26
CTRP108-ILE128
DILE6-PHE26
DTRP108-ILE128
EILE6-PHE26

site_idSWS_FT_FI3
Number of Residues480
DetailsTOPO_DOM: Periplasmic => ECO:0000255|HAMAP-Rule:MF_01458
ChainResidueDetails
ATYR27-PHE107
BTYR27-PHE107
CTYR27-PHE107
DTYR27-PHE107
ETYR27-PHE107
FTYR27-PHE107

site_idSWS_FT_FI4
Number of Residues6
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01458, ECO:0000269|PubMed:16484367
ChainResidueDetails
AGLU424
BGLU424
CGLU424
DGLU424
EGLU424
FGLU424

site_idSWS_FT_FI5
Number of Residues48
DetailsBINDING: BINDING => ECO:0000269|PubMed:16484367
ChainResidueDetails
AGLY164
BGLY204
BLEU209
BHIS343
BGLU371
BTYR423
BHIS427
BASP500
CGLY164
CGLY204
CLEU209
AGLY204
CHIS343
CGLU371
CTYR423
CHIS427
CASP500
DGLY164
DGLY204
DLEU209
DHIS343
DGLU371
ALEU209
DTYR423
DHIS427
DASP500
EGLY164
EGLY204
ELEU209
EHIS343
EGLU371
ETYR423
EHIS427
AHIS343
EASP500
FGLY164
FGLY204
FLEU209
FHIS343
FGLU371
FTYR423
FHIS427
FASP500
AGLU371
ATYR423
AHIS427
AASP500
BGLY164

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PDB entries from 2024-08-14

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