7TCS

M379A mutant tyrosine phenol-lyase complexed with L-methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006520	biological_process	amino acid metabolic process
A	0006570	biological_process	tyrosine metabolic process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016829	molecular_function	lyase activity
A	0016830	molecular_function	carbon-carbon lyase activity
A	0050371	molecular_function	tyrosine phenol-lyase activity
B	0006520	biological_process	amino acid metabolic process
B	0006570	biological_process	tyrosine metabolic process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016829	molecular_function	lyase activity
B	0016830	molecular_function	carbon-carbon lyase activity
B	0050371	molecular_function	tyrosine phenol-lyase activity
C	0006520	biological_process	amino acid metabolic process
C	0006570	biological_process	tyrosine metabolic process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016829	molecular_function	lyase activity
C	0016830	molecular_function	carbon-carbon lyase activity
C	0050371	molecular_function	tyrosine phenol-lyase activity
D	0006520	biological_process	amino acid metabolic process
D	0006570	biological_process	tyrosine metabolic process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016829	molecular_function	lyase activity
D	0016830	molecular_function	carbon-carbon lyase activity
D	0050371	molecular_function	tyrosine phenol-lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00853
Number of Residues	19
Details	BETA_ELIM_LYASE Beta-eliminating lyases pyridoxal-phosphate attachment site. YaDgctMSGKKDcLVnIGG

Chain	Residue	Details
A	TYR247-GLY265

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine

Catalytic Information from CSA

Chain	Residue	Details
A	TYR71	proton acceptor, proton donor
A	PHE123	steric role
A	THR124	electrostatic stabiliser
A	ASP214	electrostatic stabiliser
A	LYS257	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
A	ARG381	electrostatic stabiliser
A	PHE448	electrostatic stabiliser, ground state destabiliser

Chain	Residue	Details
B	TYR71	proton acceptor, proton donor
B	PHE123	steric role
B	THR124	electrostatic stabiliser
B	ASP214	electrostatic stabiliser
B	LYS257	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
B	ARG381	electrostatic stabiliser
B	PHE448	electrostatic stabiliser, ground state destabiliser

Chain	Residue	Details
C	TYR71	proton acceptor, proton donor
C	PHE123	steric role
C	THR124	electrostatic stabiliser
C	ASP214	electrostatic stabiliser
C	LYS257	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
C	ARG381	electrostatic stabiliser
C	PHE448	electrostatic stabiliser, ground state destabiliser

Chain	Residue	Details
D	TYR71	proton acceptor, proton donor
D	PHE123	steric role
D	THR124	electrostatic stabiliser
D	ASP214	electrostatic stabiliser
D	LYS257	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
D	ARG381	electrostatic stabiliser
D	PHE448	electrostatic stabiliser, ground state destabiliser