7TCE

Crystal structure of delta sub IV Rhodobacter Sphaeroides bc1 with the antimalarial drug atovaquone.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0022904	biological_process	respiratory electron transport chain
A	0045275	cellular_component	respiratory chain complex III
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
C	0005886	cellular_component	plasma membrane
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	1902600	biological_process	proton transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0009055	molecular_function	electron transfer activity
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0022904	biological_process	respiratory electron transport chain
E	0045275	cellular_component	respiratory chain complex III
E	0046872	molecular_function	metal ion binding
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0009055	molecular_function	electron transfer activity
F	0020037	molecular_function	heme binding
F	0046872	molecular_function	metal ion binding
F	0070469	cellular_component	respirasome
G	0005886	cellular_component	plasma membrane
G	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0046872	molecular_function	metal ion binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
K	0009055	molecular_function	electron transfer activity
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0022904	biological_process	respiratory electron transport chain
K	0045275	cellular_component	respiratory chain complex III
K	0046872	molecular_function	metal ion binding
K	0070469	cellular_component	respirasome
K	1902600	biological_process	proton transmembrane transport
L	0005886	cellular_component	plasma membrane
L	0009055	molecular_function	electron transfer activity
L	0020037	molecular_function	heme binding
L	0046872	molecular_function	metal ion binding
L	0070469	cellular_component	respirasome
M	0005886	cellular_component	plasma membrane
M	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0046872	molecular_function	metal ion binding
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
M	1902600	biological_process	proton transmembrane transport
O	0005886	cellular_component	plasma membrane
O	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
O	0009055	molecular_function	electron transfer activity
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0022904	biological_process	respiratory electron transport chain
O	0045275	cellular_component	respiratory chain complex III
O	0046872	molecular_function	metal ion binding
O	0070469	cellular_component	respirasome
O	1902600	biological_process	proton transmembrane transport
P	0005886	cellular_component	plasma membrane
P	0009055	molecular_function	electron transfer activity
P	0020037	molecular_function	heme binding
P	0046872	molecular_function	metal ion binding
P	0070469	cellular_component	respirasome
Q	0005886	cellular_component	plasma membrane
Q	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Q	0016020	cellular_component	membrane
Q	0016491	molecular_function	oxidoreductase activity
Q	0046872	molecular_function	metal ion binding
Q	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Q	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	TRANSMEM: Helical; Note=Anchors to the membrane => ECO:0000255

Chain	Residue	Details
A	PRO409-GLU445
E	SER2-VAL49
E	ARG114-TRP129
E	HIS217-ASP252
E	PRO347-LYS364
E	PRO409-GLU445
K	SER2-VAL49
K	ARG114-TRP129
K	HIS217-ASP252
K	PRO347-LYS364
K	PRO409-GLU445
O	SER2-VAL49
O	ARG114-TRP129
O	HIS217-ASP252
O	PRO347-LYS364
O	PRO409-GLU445
B	ALA229-THR247
F	ALA229-THR247
L	ALA229-THR247
P	ALA229-THR247

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: covalent

Chain	Residue	Details
M	CYS129
M	HIS131
M	CYS149
M	HIS152
Q	CYS129
Q	HIS131
Q	CYS149
Q	HIS152
K	VAL50-MET67
K	TYR95-PHE113
K	ILE130-LEU149
K	PHE194-PHE216
K	VAL253-MET270
K	PHE330-VAL346
K	ILE365-ALA382
K	TYR389-LEU408
O	VAL50-MET67
O	TYR95-PHE113
O	ILE130-LEU149
O	PHE194-PHE216
O	VAL253-MET270
O	PHE330-VAL346
O	ILE365-ALA382
O	TYR389-LEU408
B	CYS36
B	CYS39
F	CYS36
F	CYS39
L	CYS36
L	CYS39
P	CYS36
P	CYS39

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: axial binding residue

Chain	Residue	Details
E	HIS68-ARG94
E	PRO150-ARG193
E	PRO271-LYS329
E	GLN383-PRO388
K	HIS68-ARG94
K	PRO150-ARG193
K	PRO271-LYS329
K	GLN383-PRO388
O	HIS68-ARG94
O	PRO150-ARG193
O	PRO271-LYS329
O	GLN383-PRO388
B	HIS40
F	HIS40
L	HIS40
P	HIS40

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00433

Chain	Residue	Details
E	HIS97
E	HIS111
E	HIS198
E	HIS212
K	HIS97
K	HIS111
K	HIS198
K	HIS212
O	HIS97
O	HIS111
O	HIS198
O	HIS212
B	MET185
F	MET185
L	MET185
P	MET185

---