7T7Q

R-27 In Complex with S. aureus DHFR and alpha-NADPH - Remediated for comparison with tNADPH

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004146	molecular_function	dihydrofolate reductase activity
X	0005829	cellular_component	cytosol
X	0006730	biological_process	one-carbon metabolic process
X	0016491	molecular_function	oxidoreductase activity
X	0044281	biological_process	small molecule metabolic process
X	0046452	biological_process	dihydrofolate metabolic process
X	0046654	biological_process	tetrahydrofolate biosynthetic process
X	0046655	biological_process	folic acid metabolic process
X	0050661	molecular_function	NADP binding
X	0070401	molecular_function	NADP+ binding

Functional Information from PROSITE/UniProt

site_id	PS00075
Number of Residues	23
Details	DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS

Chain	Residue	Details
X	VAL13-SER35

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	155
Details	Domain: {"description":"DHFR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00660","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	19
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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