7SXA
T-Plastin-F-actin complex, pre-bundling intermediate state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003779 | molecular_function | actin binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005884 | cellular_component | actin filament |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0032432 | cellular_component | actin filament bundle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051015 | molecular_function | actin filament binding |
| A | 0051017 | biological_process | actin filament bundle assembly |
| A | 0051639 | biological_process | actin filament network formation |
| A | 0060348 | biological_process | bone development |
| B | 0001725 | cellular_component | stress fiber |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005865 | cellular_component | striated muscle thin filament |
| B | 0005884 | cellular_component | actin filament |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030240 | biological_process | skeletal muscle thin filament assembly |
| B | 0048741 | biological_process | skeletal muscle fiber development |
| C | 0001725 | cellular_component | stress fiber |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005865 | cellular_component | striated muscle thin filament |
| C | 0005884 | cellular_component | actin filament |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030240 | biological_process | skeletal muscle thin filament assembly |
| C | 0048741 | biological_process | skeletal muscle fiber development |
| D | 0001725 | cellular_component | stress fiber |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005865 | cellular_component | striated muscle thin filament |
| D | 0005884 | cellular_component | actin filament |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0030240 | biological_process | skeletal muscle thin filament assembly |
| D | 0048741 | biological_process | skeletal muscle fiber development |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DLNSNGFICdyEL |
| Chain | Residue | Details |
| A | ASP25-LEU37 | |
| A | ASP65-PHE77 |
| site_id | PS00019 |
| Number of Residues | 10 |
| Details | ACTININ_1 Actinin-type actin-binding domain signature 1. EKyAFVNWIN |
| Chain | Residue | Details |
| A | GLU125-ASN134 | |
| A | GLU399-ASN408 |
| site_id | PS00020 |
| Number of Residues | 25 |
| Details | ACTININ_2 Actinin-type actin-binding domain signature 2. VvNIGAeDLrAgkphLvLGLLWqII |
| Chain | Residue | Details |
| A | VAL211-ILE235 | |
| A | LEU478-MET502 |
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| C | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WITKqEYDE |
| Chain | Residue | Details |
| C | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| C | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | MOD_RES: N-acetylcysteine; in intermediate form => ECO:0000250|UniProtKB:P62737 |
| Chain | Residue | Details |
| C | CYS0 | |
| B | CYS0 | |
| D | CYS0 | |
| A | GLU36 | |
| A | ASP65 | |
| A | ASN67 | |
| A | ASP69 | |
| A | LYS71 | |
| A | GLU76 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N-acetylaspartate; in Actin, alpha skeletal muscle => ECO:0000269|PubMed:456601 |
| Chain | Residue | Details |
| C | ASP1 | |
| B | ASP1 | |
| D | ASP1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P68134 |
| Chain | Residue | Details |
| C | MET44 | |
| C | MET47 | |
| B | MET44 | |
| B | MET47 | |
| D | MET44 | |
| D | MET47 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:12356759, ECO:0007744|PDB:1MDU |
| Chain | Residue | Details |
| C | HIC73 | |
| B | HIC73 | |
| D | HIC73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133 |
| Chain | Residue | Details |
| C | LYS84 | |
| B | LYS84 | |
| D | LYS84 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | THR391 |
