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7SSZ

Structure of human Kv1.3 with A0194009G09 nanobodies

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0003674molecular_functionmolecular_function
A0005216molecular_functionmonoatomic ion channel activity
A0005244molecular_functionvoltage-gated monoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005575cellular_componentcellular_component
A0005886cellular_componentplasma membrane
A0006091biological_processgeneration of precursor metabolites and energy
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0008218biological_processbioluminescence
A0015271molecular_functionoutward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0021554biological_processoptic nerve development
A0022038biological_processcorpus callosum development
A0030424cellular_componentaxon
A0034702cellular_componentmonoatomic ion channel complex
A0042734cellular_componentpresynaptic membrane
A0044305cellular_componentcalyx of Held
A0045121cellular_componentmembrane raft
A0045211cellular_componentpostsynaptic membrane
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0098978cellular_componentglutamatergic synapse
B0001508biological_processaction potential
B0003674molecular_functionmolecular_function
B0005216molecular_functionmonoatomic ion channel activity
B0005244molecular_functionvoltage-gated monoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005575cellular_componentcellular_component
B0005886cellular_componentplasma membrane
B0006091biological_processgeneration of precursor metabolites and energy
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0008218biological_processbioluminescence
B0015271molecular_functionoutward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0021554biological_processoptic nerve development
B0022038biological_processcorpus callosum development
B0030424cellular_componentaxon
B0034702cellular_componentmonoatomic ion channel complex
B0042734cellular_componentpresynaptic membrane
B0044305cellular_componentcalyx of Held
B0045121cellular_componentmembrane raft
B0045211cellular_componentpostsynaptic membrane
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0098978cellular_componentglutamatergic synapse
C0001508biological_processaction potential
C0003674molecular_functionmolecular_function
C0005216molecular_functionmonoatomic ion channel activity
C0005244molecular_functionvoltage-gated monoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005575cellular_componentcellular_component
C0005886cellular_componentplasma membrane
C0006091biological_processgeneration of precursor metabolites and energy
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0008218biological_processbioluminescence
C0015271molecular_functionoutward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0021554biological_processoptic nerve development
C0022038biological_processcorpus callosum development
C0030424cellular_componentaxon
C0034702cellular_componentmonoatomic ion channel complex
C0042734cellular_componentpresynaptic membrane
C0044305cellular_componentcalyx of Held
C0045121cellular_componentmembrane raft
C0045211cellular_componentpostsynaptic membrane
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0098978cellular_componentglutamatergic synapse
D0001508biological_processaction potential
D0003674molecular_functionmolecular_function
D0005216molecular_functionmonoatomic ion channel activity
D0005244molecular_functionvoltage-gated monoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005575cellular_componentcellular_component
D0005886cellular_componentplasma membrane
D0006091biological_processgeneration of precursor metabolites and energy
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0008218biological_processbioluminescence
D0015271molecular_functionoutward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0021554biological_processoptic nerve development
D0022038biological_processcorpus callosum development
D0030424cellular_componentaxon
D0034702cellular_componentmonoatomic ion channel complex
D0042734cellular_componentpresynaptic membrane
D0044305cellular_componentcalyx of Held
D0045121cellular_componentmembrane raft
D0045211cellular_componentpostsynaptic membrane
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
D0098978cellular_componentglutamatergic synapse
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1404
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ARG234
CCYS317-ILE327
CLYS382-GLU397
CASN482-VAL575
DMET1-ARG234
DCYS317-ILE327
DLYS382-GLU397
DASN482-VAL575
ACYS317-ILE327
ALYS382-GLU397
AASN482-VAL575
BMET1-ARG234
BCYS317-ILE327
BLYS382-GLU397
BASN482-VAL575
CMET1-ARG234

site_idSWS_FT_FI2
Number of Residues72
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
AGLY235-LEU253
BGLY235-LEU253
CGLY235-LEU253
DGLY235-LEU253

site_idSWS_FT_FI3
Number of Residues372
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLU254-PRO294
DGLU254-PRO294
DGLU349-ILE362
DPHE418-LYS458
AGLU349-ILE362
APHE418-LYS458
BGLU254-PRO294
BGLU349-ILE362
BPHE418-LYS458
CGLU254-PRO294
CGLU349-ILE362
CPHE418-LYS458

site_idSWS_FT_FI4
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
APHE295-ALA316
BPHE295-ALA316
CPHE295-ALA316
DPHE295-ALA316

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
AMET328-ALA348
BMET328-ALA348
CMET328-ALA348
DMET328-ALA348

site_idSWS_FT_FI6
Number of Residues72
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
ALEU363-SER381
BLEU363-SER381
CLEU363-SER381
DLEU363-SER381

site_idSWS_FT_FI7
Number of Residues76
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
ALEU398-TYR417
BLEU398-TYR417
CLEU398-TYR417
DLEU398-TYR417

site_idSWS_FT_FI8
Number of Residues88
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
AILE459-SER481
BILE459-SER481
CILE459-SER481
DILE459-SER481

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000255
ChainResidueDetails
ASER520
BSER520
CSER520
DSER520

site_idSWS_FT_FI10
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
ACYS317
BCYS317
CCYS317
DCYS317

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN279
BASN279
CASN279
DASN279

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132
ChainResidueDetails
ATYR654
BTYR654
CTYR654
DTYR654

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132
ChainResidueDetails
AGLY653
AGLY655
BGLY653
BGLY655
CGLY653
CGLY655
DGLY653
DGLY655

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PDB entries from 2024-08-07

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