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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7SSV

Structure of human Kv1.3 with Fab-ShK fusion

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005244molecular_functionvoltage-gated monoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006091biological_processgeneration of precursor metabolites and energy
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0008218biological_processbioluminescence
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0048471cellular_componentperinuclear region of cytoplasm
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005244molecular_functionvoltage-gated monoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006091biological_processgeneration of precursor metabolites and energy
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0008218biological_processbioluminescence
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0048471cellular_componentperinuclear region of cytoplasm
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
C0001508biological_processaction potential
C0005216molecular_functionmonoatomic ion channel activity
C0005244molecular_functionvoltage-gated monoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006091biological_processgeneration of precursor metabolites and energy
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0008218biological_processbioluminescence
C0016020cellular_componentmembrane
C0030424cellular_componentaxon
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0048471cellular_componentperinuclear region of cytoplasm
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005244molecular_functionvoltage-gated monoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006091biological_processgeneration of precursor metabolites and energy
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0008218biological_processbioluminescence
D0016020cellular_componentmembrane
D0030424cellular_componentaxon
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0048471cellular_componentperinuclear region of cytoplasm
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
ChainResidueDetails
LTYR195-HIS201
HTYR246-HIS252
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues100
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues160
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-07-09

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