7SLA
CryoEM structure of SGLT1 at 3.15 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000017 | biological_process | alpha-glucoside transport |
| A | 0001951 | biological_process | intestinal D-glucose absorption |
| A | 0005354 | molecular_function | galactose transmembrane transporter activity |
| A | 0005355 | molecular_function | glucose transmembrane transporter activity |
| A | 0005367 | molecular_function | myo-inositol:sodium symporter activity |
| A | 0005372 | molecular_function | water transmembrane transporter activity |
| A | 0005412 | molecular_function | glucose:sodium symporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005769 | cellular_component | early endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015146 | molecular_function | pentose transmembrane transporter activity |
| A | 0015150 | molecular_function | fucose transmembrane transporter activity |
| A | 0015151 | molecular_function | alpha-glucoside transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015370 | molecular_function | solute:sodium symporter activity |
| A | 0015371 | molecular_function | galactose:sodium symporter activity |
| A | 0015750 | biological_process | pentose transmembrane transport |
| A | 0015756 | biological_process | fucose transmembrane transport |
| A | 0015757 | biological_process | galactose transmembrane transport |
| A | 0015798 | biological_process | myo-inositol transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0035377 | biological_process | transepithelial water transport |
| A | 0035623 | biological_process | renal glucose absorption |
| A | 0043229 | cellular_component | intracellular organelle |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0055056 | molecular_function | D-glucose transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097708 | cellular_component | intracellular vesicle |
| A | 0098708 | biological_process | glucose import across plasma membrane |
| A | 0098719 | biological_process | sodium ion import across plasma membrane |
| A | 0106001 | biological_process | intestinal hexose absorption |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1904659 | biological_process | glucose transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00456 |
| Number of Residues | 26 |
| Details | NA_SOLUT_SYMP_1 Sodium:solute symporter family signature 1. GwnLylsIILLLAItalYTitGGLaA |
| Chain | Residue | Details |
| A | GLY174-ALA199 |
| site_id | PS00457 |
| Number of Residues | 21 |
| Details | NA_SOLUT_SYMP_2 Sodium:solute symporter family signature 2. AIfwkRvneqGAfwGLILGlL |
| Chain | Residue | Details |
| A | ALA474-LEU494 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 261 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ASP28 | |
| A | GLY86-ALA105 | |
| A | SER164-TYR178 | |
| A | ASP230-PRO277 | |
| A | SER335-GLY380 | |
| A | GLN445-TYR455 | |
| A | TYR506-TYR526 | |
| A | ARG564-THR643 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 262 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE29-LYS49 | |
| A | ILE424-VAL444 | |
| A | ILE456-PHE476 | |
| A | ALA485-ALA505 | |
| A | VAL644-ALA664 | |
| A | MET65-ILE85 | |
| A | LEU106-VAL126 | |
| A | VAL143-PHE163 | |
| A | LEU179-ILE201 | |
| A | LEU209-TYR229 | |
| A | GLY278-VAL298 | |
| A | CYS314-ILE334 | |
| A | LEU381-ALA401 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 77 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | THR50-SER64 | |
| A | THR127-GLN142 | |
| A | TYR202-THR208 | |
| A | GLN299-GLY313 | |
| A | SER402-MET423 | |
| A | TRP477-GLY484 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | INTRAMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU527-LEU563 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLN457 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Implicated in sodium coupling => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY43 | |
| A | ARG300 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Involved in sugar-binding/transport and inhibitor binding => ECO:0000250 |
| Chain | Residue | Details |
| A | SER460 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8C3K6 |
| Chain | Residue | Details |
| A | THR587 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8567640 |
| Chain | Residue | Details |
| A | ASN248 |
