7SK9
Cryo-EM structure of human ACKR3 in complex with a small molecule partial agonist CCX662, and an intracellular Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001570 | biological_process | vasculogenesis |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0005044 | molecular_function | scavenger receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005769 | cellular_component | early endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005905 | cellular_component | clathrin-coated pit |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006955 | biological_process | immune response |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0009986 | cellular_component | cell surface |
| A | 0015026 | molecular_function | coreceptor activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016493 | molecular_function | C-C chemokine receptor activity |
| A | 0016494 | molecular_function | C-X-C chemokine receptor activity |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0019956 | molecular_function | chemokine binding |
| A | 0019957 | molecular_function | C-C chemokine binding |
| A | 0019958 | molecular_function | C-X-C chemokine binding |
| A | 0021557 | biological_process | oculomotor nerve development |
| A | 0031623 | biological_process | receptor internalization |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0070098 | biological_process | chemokine-mediated signaling pathway |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 1902230 | biological_process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| A | 1905322 | biological_process | positive regulation of mesenchymal stem cell migration |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIfFLTCMSVDRYLsI |
| Chain | Residue | Details |
| A | GLY130-ILE146 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| E | TYR193-HIS199 | |
| F | TYR211-HIS217 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 58 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
