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7SK7

Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, and an extracellular Fab

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001570biological_processvasculogenesis
A0004930molecular_functionG protein-coupled receptor activity
A0005044molecular_functionscavenger receptor activity
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006935biological_processchemotaxis
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008285biological_processnegative regulation of cell population proliferation
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0015026molecular_functioncoreceptor activity
A0016020cellular_componentmembrane
A0016493molecular_functionC-C chemokine receptor activity
A0016494molecular_functionC-X-C chemokine receptor activity
A0019722biological_processcalcium-mediated signaling
A0019956molecular_functionchemokine binding
A0019957molecular_functionC-C chemokine binding
A0019958molecular_functionC-X-C chemokine binding
A0021557biological_processoculomotor nerve development
A0031623biological_processreceptor internalization
A0055037cellular_componentrecycling endosome
A0060326biological_processcell chemotaxis
A0070098biological_processchemokine-mediated signaling pathway
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1905322biological_processpositive regulation of mesenchymal stem cell migration
B0001666biological_processresponse to hypoxia
B0001764biological_processneuron migration
B0001938biological_processpositive regulation of endothelial cell proliferation
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006874biological_processintracellular calcium ion homeostasis
B0006935biological_processchemotaxis
B0006955biological_processimmune response
B0007155biological_processcell adhesion
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007411biological_processaxon guidance
B0008009molecular_functionchemokine activity
B0008015biological_processblood circulation
B0008064biological_processregulation of actin polymerization or depolymerization
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0008344biological_processadult locomotory behavior
B0009612biological_processresponse to mechanical stimulus
B0009615biological_processresponse to virus
B0009897cellular_componentexternal side of plasma membrane
B0022029biological_processtelencephalon cell migration
B0030335biological_processpositive regulation of cell migration
B0031012cellular_componentextracellular matrix
B0031100biological_processanimal organ regeneration
B0033603biological_processpositive regulation of dopamine secretion
B0033622biological_processintegrin activation
B0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
B0038160biological_processCXCL12-activated CXCR4 signaling pathway
B0042379molecular_functionchemokine receptor binding
B0043434biological_processresponse to peptide hormone
B0045236molecular_functionCXCR chemokine receptor binding
B0045666biological_processpositive regulation of neuron differentiation
B0045785biological_processpositive regulation of cell adhesion
B0048842biological_processpositive regulation of axon extension involved in axon guidance
B0050921biological_processpositive regulation of chemotaxis
B0050930biological_processinduction of positive chemotaxis
B0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
B0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
B0051924biological_processregulation of calcium ion transport
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0070098biological_processchemokine-mediated signaling pathway
B0090026biological_processpositive regulation of monocyte chemotaxis
B0090280biological_processpositive regulation of calcium ion import
B1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
B1903237biological_processnegative regulation of leukocyte tethering or rolling
B1904018biological_processpositive regulation of vasculature development
B1990478biological_processresponse to ultrasound
B1990869biological_processcellular response to chemokine
B2000406biological_processpositive regulation of T cell migration
B2000669biological_processnegative regulation of dendritic cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIfFLTCMSVDRYLsI
ChainResidueDetails
AGLY130-ILE146

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
DTYR209-HIS215
CTYR193-HIS199

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues66
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues4
DetailsRegion: {"description":"Receptor and heparin binding","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues14
DetailsRegion: {"description":"Receptor binding"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues13
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues3
DetailsSite: {"description":"Important for integrin interaction and activation","evidences":[{"source":"PubMed","id":"29301984","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues1
DetailsSite: {"description":"Important for dimer formation"}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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