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7SK1

TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5

Functional Information from GO Data
ChainGOidnamespacecontents
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0015271molecular_functionoutward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0022841molecular_functionpotassium ion leak channel activity
A0030322biological_processstabilization of membrane potential
A0030425cellular_componentdendrite
A0031526cellular_componentbrush border membrane
A0034705cellular_componentpotassium channel complex
A0035094biological_processresponse to nicotine
A0035725biological_processsodium ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043204cellular_componentperikaryon
A0043231cellular_componentintracellular membrane-bounded organelle
A0045202cellular_componentsynapse
A0055037cellular_componentrecycling endosome
A0060075biological_processregulation of resting membrane potential
A0071805biological_processpotassium ion transmembrane transport
A0097060cellular_componentsynaptic membrane
A1902937cellular_componentinward rectifier potassium channel complex
B0005242molecular_functioninward rectifier potassium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0015271molecular_functionoutward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0022841molecular_functionpotassium ion leak channel activity
B0030322biological_processstabilization of membrane potential
B0030425cellular_componentdendrite
B0031526cellular_componentbrush border membrane
B0034705cellular_componentpotassium channel complex
B0035094biological_processresponse to nicotine
B0035725biological_processsodium ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043204cellular_componentperikaryon
B0043231cellular_componentintracellular membrane-bounded organelle
B0045202cellular_componentsynapse
B0055037cellular_componentrecycling endosome
B0060075biological_processregulation of resting membrane potential
B0071805biological_processpotassium ion transmembrane transport
B0097060cellular_componentsynaptic membrane
B1902937cellular_componentinward rectifier potassium channel complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues222
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
AMET1-ALA20
ATHR157-ILE181
ACYS268-HIS336
BMET1-ALA20
BTHR157-ILE181
BCYS268-HIS336

site_idSWS_FT_FI2
Number of Residues172
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
ATRP21-PHE41
APHE133-VAL156
AVAL182-VAL202
ALEU244-PHE267
BTRP21-PHE41
BPHE133-VAL156
BVAL182-VAL202
BLEU244-PHE267

site_idSWS_FT_FI3
Number of Residues178
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
ASER42-ASP103
ATHR123-ALA132
APHE203-ASN211
AVAL232-GLU243
BSER42-ASP103
BTHR123-ALA132
BPHE203-ASN211
BVAL232-GLU243

site_idSWS_FT_FI4
Number of Residues24
DetailsINTRAMEM: Helical; Name=Pore helix 1 => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
APHE104-SER116
BPHE104-SER116

site_idSWS_FT_FI5
Number of Residues22
DetailsINTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
ATHR117-HIS122
ATHR225-TYR231
BTHR117-HIS122
BTHR225-TYR231

site_idSWS_FT_FI6
Number of Residues24
DetailsINTRAMEM: Helical; Name=Pore helix 2 => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
APHE212-SER224
BPHE212-SER224

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Important for increased permeability to Na(+) when K(+) levels are subphysiological => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
BTHR118
ATHR118

site_idSWS_FT_FI8
Number of Residues4
DetailsSITE: Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
BLEU146
BLEU261
ALEU146
ALEU261

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
BSER326
ASER326

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN95
AASN95

site_idSWS_FT_FI11
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:O00180
ChainResidueDetails
BLYS274
ALYS274

219869

PDB entries from 2024-05-15

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