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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7SK1

TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5

Functional Information from GO Data
ChainGOidnamespacecontents
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0014047biological_processglutamate secretion
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0022834molecular_functionligand-gated channel activity
A0022841molecular_functionpotassium ion leak channel activity
A0030425cellular_componentdendrite
A0031410cellular_componentcytoplasmic vesicle
A0031526cellular_componentbrush border membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034705cellular_componentpotassium channel complex
A0035094biological_processresponse to nicotine
A0035725biological_processsodium ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043204cellular_componentperikaryon
A0043231cellular_componentintracellular membrane-bounded organelle
A0045202cellular_componentsynapse
A0046982molecular_functionprotein heterodimerization activity
A0055037cellular_componentrecycling endosome
A0060075biological_processregulation of resting membrane potential
A0060078biological_processregulation of postsynaptic membrane potential
A0071468biological_processcellular response to acidic pH
A0071805biological_processpotassium ion transmembrane transport
A0097060cellular_componentsynaptic membrane
A1902476biological_processchloride transmembrane transport
A1902937cellular_componentinward rectifier potassium channel complex
A1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0005242molecular_functioninward rectifier potassium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0014047biological_processglutamate secretion
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0022834molecular_functionligand-gated channel activity
B0022841molecular_functionpotassium ion leak channel activity
B0030425cellular_componentdendrite
B0031410cellular_componentcytoplasmic vesicle
B0031526cellular_componentbrush border membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034705cellular_componentpotassium channel complex
B0035094biological_processresponse to nicotine
B0035725biological_processsodium ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043204cellular_componentperikaryon
B0043231cellular_componentintracellular membrane-bounded organelle
B0045202cellular_componentsynapse
B0046982molecular_functionprotein heterodimerization activity
B0055037cellular_componentrecycling endosome
B0060075biological_processregulation of resting membrane potential
B0060078biological_processregulation of postsynaptic membrane potential
B0071468biological_processcellular response to acidic pH
B0071805biological_processpotassium ion transmembrane transport
B0097060cellular_componentsynaptic membrane
B1902476biological_processchloride transmembrane transport
B1902937cellular_componentinward rectifier potassium channel complex
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues172
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues178
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues24
DetailsIntramembrane: {"description":"Helical; Name=Pore helix 1","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues22
DetailsIntramembrane: {"evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues48
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsIntramembrane: {"description":"Helical; Name=Pore helix 2","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues10
DetailsRegion: {"description":"Selectivity filter 1","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues10
DetailsRegion: {"description":"Selectivity filter 2","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsSite: {"description":"Important for increased permeability to Na(+) when K(+) levels are subphysiological","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsSite: {"description":"Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-07-23

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