7SK1
TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005242 | molecular_function | inward rectifier potassium channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0014047 | biological_process | glutamate secretion |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0022834 | molecular_function | ligand-gated channel activity |
| A | 0022841 | molecular_function | potassium ion leak channel activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0034705 | cellular_component | potassium channel complex |
| A | 0035094 | biological_process | response to nicotine |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043204 | cellular_component | perikaryon |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0060075 | biological_process | regulation of resting membrane potential |
| A | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| A | 0071468 | biological_process | cellular response to acidic pH |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0097060 | cellular_component | synaptic membrane |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1902937 | cellular_component | inward rectifier potassium channel complex |
| A | 1905030 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| B | 0005242 | molecular_function | inward rectifier potassium channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0005768 | cellular_component | endosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0014047 | biological_process | glutamate secretion |
| B | 0016020 | cellular_component | membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0022834 | molecular_function | ligand-gated channel activity |
| B | 0022841 | molecular_function | potassium ion leak channel activity |
| B | 0030425 | cellular_component | dendrite |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031526 | cellular_component | brush border membrane |
| B | 0034705 | cellular_component | potassium channel complex |
| B | 0035094 | biological_process | response to nicotine |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043204 | cellular_component | perikaryon |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0055037 | cellular_component | recycling endosome |
| B | 0060075 | biological_process | regulation of resting membrane potential |
| B | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| B | 0071468 | biological_process | cellular response to acidic pH |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0097060 | cellular_component | synaptic membrane |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1902937 | cellular_component | inward rectifier potassium channel complex |
| B | 1905030 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 178 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Intramembrane: {"description":"Pore-forming; Name=PH1","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Intramembrane: {"evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 48 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M3","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Intramembrane: {"description":"Pore-forming; Name=PH2","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=M4","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 1","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 2","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for increased permeability to Na(+) when K(+) levels are subphysiological","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Site: {"description":"Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"O00180","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
