Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7SJ8

13pf wildtype microtubule from recombinant human tubulin decorated with kinesin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003725	molecular_function	double-stranded RNA binding
A	0003924	molecular_function	GTPase activity
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0051301	biological_process	cell division
A	0071353	biological_process	cellular response to interleukin-4
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0007411	biological_process	axon guidance
B	0015630	cellular_component	microtubule cytoskeleton
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030182	biological_process	neuron differentiation
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0038007	biological_process	netrin-activated signaling pathway
B	0042277	molecular_function	peptide binding
B	0042995	cellular_component	cell projection
B	0043025	cellular_component	neuronal cell body
B	0045171	cellular_component	intercellular bridge
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071944	cellular_component	cell periphery
B	0072686	cellular_component	mitotic spindle
B	1990791	biological_process	dorsal root ganglion development
B	1990890	molecular_function	netrin receptor binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003725	molecular_function	double-stranded RNA binding
C	0003924	molecular_function	GTPase activity
C	0005198	molecular_function	structural molecule activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0030705	biological_process	cytoskeleton-dependent intracellular transport
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0051301	biological_process	cell division
C	0071353	biological_process	cellular response to interleukin-4
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0007411	biological_process	axon guidance
D	0015630	cellular_component	microtubule cytoskeleton
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030182	biological_process	neuron differentiation
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0030426	cellular_component	growth cone
D	0038007	biological_process	netrin-activated signaling pathway
D	0042277	molecular_function	peptide binding
D	0042995	cellular_component	cell projection
D	0043025	cellular_component	neuronal cell body
D	0045171	cellular_component	intercellular bridge
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0071944	cellular_component	cell periphery
D	0072686	cellular_component	mitotic spindle
D	1990791	biological_process	dorsal root ganglion development
D	1990890	molecular_function	netrin receptor binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0003725	molecular_function	double-stranded RNA binding
E	0003924	molecular_function	GTPase activity
E	0005198	molecular_function	structural molecule activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0007017	biological_process	microtubule-based process
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0030705	biological_process	cytoskeleton-dependent intracellular transport
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0051301	biological_process	cell division
E	0071353	biological_process	cellular response to interleukin-4
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0007411	biological_process	axon guidance
F	0015630	cellular_component	microtubule cytoskeleton
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030182	biological_process	neuron differentiation
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0030426	cellular_component	growth cone
F	0038007	biological_process	netrin-activated signaling pathway
F	0042277	molecular_function	peptide binding
F	0042995	cellular_component	cell projection
F	0043025	cellular_component	neuronal cell body
F	0045171	cellular_component	intercellular bridge
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0071944	cellular_component	cell periphery
F	0072686	cellular_component	mitotic spindle
F	1990791	biological_process	dorsal root ganglion development
F	1990890	molecular_function	netrin receptor binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0003924	molecular_function	GTPase activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0007411	biological_process	axon guidance
G	0015630	cellular_component	microtubule cytoskeleton
G	0030027	cellular_component	lamellipodium
G	0030175	cellular_component	filopodium
G	0030182	biological_process	neuron differentiation
G	0030424	cellular_component	axon
G	0030425	cellular_component	dendrite
G	0030426	cellular_component	growth cone
G	0038007	biological_process	netrin-activated signaling pathway
G	0042277	molecular_function	peptide binding
G	0042995	cellular_component	cell projection
G	0043025	cellular_component	neuronal cell body
G	0045171	cellular_component	intercellular bridge
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0071944	cellular_component	cell periphery
G	0072686	cellular_component	mitotic spindle
G	1990791	biological_process	dorsal root ganglion development
G	1990890	molecular_function	netrin receptor binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0003924	molecular_function	GTPase activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
H	0007411	biological_process	axon guidance
H	0015630	cellular_component	microtubule cytoskeleton
H	0030027	cellular_component	lamellipodium
H	0030175	cellular_component	filopodium
H	0030182	biological_process	neuron differentiation
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0030426	cellular_component	growth cone
H	0038007	biological_process	netrin-activated signaling pathway
H	0042277	molecular_function	peptide binding
H	0042995	cellular_component	cell projection
H	0043025	cellular_component	neuronal cell body
H	0045171	cellular_component	intercellular bridge
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	0071944	cellular_component	cell periphery
H	0072686	cellular_component	mitotic spindle
H	1990791	biological_process	dorsal root ganglion development
H	1990890	molecular_function	netrin receptor binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0003924	molecular_function	GTPase activity
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0007411	biological_process	axon guidance
I	0015630	cellular_component	microtubule cytoskeleton
I	0030027	cellular_component	lamellipodium
I	0030175	cellular_component	filopodium
I	0030182	biological_process	neuron differentiation
I	0030424	cellular_component	axon
I	0030425	cellular_component	dendrite
I	0030426	cellular_component	growth cone
I	0038007	biological_process	netrin-activated signaling pathway
I	0042277	molecular_function	peptide binding
I	0042995	cellular_component	cell projection
I	0043025	cellular_component	neuronal cell body
I	0045171	cellular_component	intercellular bridge
I	0046872	molecular_function	metal ion binding
I	0070062	cellular_component	extracellular exosome
I	0071944	cellular_component	cell periphery
I	0072686	cellular_component	mitotic spindle
I	1990791	biological_process	dorsal root ganglion development
I	1990890	molecular_function	netrin receptor binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003725	molecular_function	double-stranded RNA binding
J	0003924	molecular_function	GTPase activity
J	0005198	molecular_function	structural molecule activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005881	cellular_component	cytoplasmic microtubule
J	0007017	biological_process	microtubule-based process
J	0015630	cellular_component	microtubule cytoskeleton
J	0016787	molecular_function	hydrolase activity
J	0030705	biological_process	cytoskeleton-dependent intracellular transport
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0051301	biological_process	cell division
J	0071353	biological_process	cellular response to interleukin-4
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0003725	molecular_function	double-stranded RNA binding
K	0003924	molecular_function	GTPase activity
K	0005198	molecular_function	structural molecule activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005881	cellular_component	cytoplasmic microtubule
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0030705	biological_process	cytoskeleton-dependent intracellular transport
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0051301	biological_process	cell division
K	0071353	biological_process	cellular response to interleukin-4
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003725	molecular_function	double-stranded RNA binding
L	0003924	molecular_function	GTPase activity
L	0005198	molecular_function	structural molecule activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0005881	cellular_component	cytoplasmic microtubule
L	0007017	biological_process	microtubule-based process
L	0015630	cellular_component	microtubule cytoskeleton
L	0016787	molecular_function	hydrolase activity
L	0030705	biological_process	cytoskeleton-dependent intracellular transport
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0051301	biological_process	cell division
L	0071353	biological_process	cellular response to interleukin-4

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
F	GLY140-GLY146

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
F	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: BINDING => ECO:0000305\|PubMed:34996871, ECO:0000305\|PubMed:35482892, ECO:0007744\|PDB:7SJ7, ECO:0007744\|PDB:7Z6S

Chain	Residue	Details
F	GLN11
D	GLY144
D	ASN204
D	ASN226
G	GLN11
G	GLY142
G	THR143
G	GLY144
G	ASN204
G	ASN226
H	GLN11
F	GLY142
H	GLY142
H	THR143
H	GLY144
H	ASN204
H	ASN226
I	GLN11
I	GLY142
I	THR143
I	GLY144
I	ASN204
F	THR143
I	ASN226
B	GLN11
B	GLY142
B	THR143
B	GLY144
B	ASN204
B	ASN226
F	GLY144
F	ASN204
F	ASN226
D	GLN11
D	GLY142
D	THR143

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
F	GLU69
C	GLU71
C	SER140
C	GLY144
C	THR145
C	THR179
C	ASN206
C	ASN228
E	GLN11
E	GLU71
E	SER140
D	GLU69
E	GLY144
E	THR145
E	THR179
E	ASN206
E	ASN228
J	GLN11
J	GLU71
J	SER140
J	GLY144
J	THR145
G	GLU69
J	THR179
J	ASN206
J	ASN228
K	GLN11
K	GLU71
K	SER140
K	GLY144
K	THR145
K	THR179
K	ASN206
H	GLU69
K	ASN228
L	GLN11
L	GLU71
L	SER140
L	GLY144
L	THR145
L	THR179
L	ASN206
L	ASN228
I	GLU69
B	GLU69
A	ASN206
A	ASN228
C	GLN11

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:34996871, ECO:0007744\|PDB:7SJ7

Chain	Residue	Details
F	SER138
D	SER138
G	SER138
H	SER138
I	SER138
B	SER138

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269\|PubMed:16371510

Chain	Residue	Details
F	SER172
D	SER172
G	SER172
H	SER172
I	SER172
B	SER172

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
F	GLU438
K	SER232
L	SER48
L	SER232
D	GLU438
G	GLU438
H	GLU438
I	GLU438
B	GLU438
J	SER48
J	SER232
K	SER48

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
F	SER444
D	SER444
G	SER444
H	SER444
I	SER444
B	SER444

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269\|Ref.6

Chain	Residue	Details
A	ARG339
C	ARG339
E	ARG339
J	ARG339
K	ARG339
L	ARG339

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68373

Chain	Residue	Details
A	SER439
C	SER439
E	SER439
J	SER439
K	SER439
L	SER439

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000269\|PubMed:32747782

Chain	Residue	Details
A	GLU443
C	GLU443
E	GLU443
J	GLU443
K	GLU443
L	GLU443

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:P68369

Chain	Residue	Details
A	GLU445
C	GLU445
E	GLU445
J	GLU445
K	GLU445
L	GLU445

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000269\|PubMed:10339593

Chain	Residue	Details
A	TYR451
C	TYR451
E	TYR451
J	TYR451
K	TYR451
L	TYR451

site_id	SWS_FT_FI12
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
A	LYS326
J	LYS326
J	LYS370
K	LYS326
K	LYS370
L	LYS326
L	LYS370
A	LYS370
C	LYS326
C	LYS370
E	LYS326
E	LYS370

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)