7SID

Human ATM Dimer Bound to Nbs1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000077	biological_process	DNA damage checkpoint signaling
A	0000166	molecular_function	nucleotide binding
A	0000425	biological_process	pexophagy
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000729	biological_process	DNA double-strand break processing
A	0000781	cellular_component	chromosome, telomeric region
A	0001541	biological_process	ovarian follicle development
A	0001756	biological_process	somitogenesis
A	0002331	biological_process	pre-B cell allelic exclusion
A	0002376	biological_process	immune system process
A	0003677	molecular_function	DNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006513	biological_process	protein monoubiquitination
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007094	biological_process	mitotic spindle assembly checkpoint signaling
A	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
A	0007127	biological_process	meiosis I
A	0007131	biological_process	reciprocal meiotic recombination
A	0007140	biological_process	male meiotic nuclear division
A	0007143	biological_process	female meiotic nuclear division
A	0007165	biological_process	signal transduction
A	0007292	biological_process	female gamete generation
A	0007420	biological_process	brain development
A	0007507	biological_process	heart development
A	0008340	biological_process	determination of adult lifespan
A	0008585	biological_process	female gonad development
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0009791	biological_process	post-embryonic development
A	0010212	biological_process	response to ionizing radiation
A	0010468	biological_process	regulation of gene expression
A	0010506	biological_process	regulation of autophagy
A	0010557	biological_process	positive regulation of macromolecule biosynthetic process
A	0010628	biological_process	positive regulation of gene expression
A	0016301	molecular_function	kinase activity
A	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
A	0016740	molecular_function	transferase activity
A	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
A	0030335	biological_process	positive regulation of cell migration
A	0030889	biological_process	negative regulation of B cell proliferation
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031410	cellular_component	cytoplasmic vesicle
A	0032210	biological_process	regulation of telomere maintenance via telomerase
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0033151	biological_process	V(D)J recombination
A	0033554	biological_process	cellular response to stress
A	0034614	biological_process	cellular response to reactive oxygen species
A	0035264	biological_process	multicellular organism growth
A	0035861	cellular_component	site of double-strand break
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
A	0036289	biological_process	peptidyl-serine autophosphorylation
A	0042159	biological_process	lipoprotein catabolic process
A	0042594	biological_process	response to starvation
A	0042770	biological_process	signal transduction in response to DNA damage
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0045141	biological_process	meiotic telomere clustering
A	0045785	biological_process	positive regulation of cell adhesion
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046777	biological_process	protein autophosphorylation
A	0048538	biological_process	thymus development
A	0048599	biological_process	oocyte development
A	0050821	biological_process	protein stabilization
A	0051402	biological_process	neuron apoptotic process
A	0051726	biological_process	regulation of cell cycle
A	0070192	biological_process	chromosome organization involved in meiotic cell cycle
A	0070534	biological_process	protein K63-linked ubiquitination
A	0071044	biological_process	histone mRNA catabolic process
A	0071300	biological_process	cellular response to retinoic acid
A	0071480	biological_process	cellular response to gamma radiation
A	0071481	biological_process	cellular response to X-ray
A	0071500	biological_process	cellular response to nitrosative stress
A	0080135	biological_process	regulation of cellular response to stress
A	0090398	biological_process	cellular senescence
A	0090399	biological_process	replicative senescence
A	0097694	biological_process	establishment of RNA localization to telomere
A	0097695	biological_process	establishment of protein-containing complex localization to telomere
A	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
A	0106310	molecular_function	protein serine kinase activity
A	0110025	biological_process	DNA strand resection involved in replication fork processing
A	1900034	biological_process	regulation of cellular response to heat
A	1901701	biological_process	cellular response to oxygen-containing compound
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904354	biological_process	negative regulation of telomere capping
A	1904358	biological_process	positive regulation of telomere maintenance via telomere lengthening
A	1904884	biological_process	positive regulation of telomerase catalytic core complex assembly
A	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
A	1990166	biological_process	protein localization to site of double-strand break
A	1990391	cellular_component	DNA repair complex
A	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
A	2000781	biological_process	positive regulation of double-strand break repair
A	2000785	biological_process	regulation of autophagosome assembly
A	2000786	biological_process	positive regulation of autophagosome assembly
C	0000045	biological_process	autophagosome assembly
C	0000077	biological_process	DNA damage checkpoint signaling
C	0000166	molecular_function	nucleotide binding
C	0000425	biological_process	pexophagy
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000729	biological_process	DNA double-strand break processing
C	0000781	cellular_component	chromosome, telomeric region
C	0001541	biological_process	ovarian follicle development
C	0001756	biological_process	somitogenesis
C	0002331	biological_process	pre-B cell allelic exclusion
C	0002376	biological_process	immune system process
C	0003677	molecular_function	DNA binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004677	molecular_function	DNA-dependent protein kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006338	biological_process	chromatin remodeling
C	0006468	biological_process	protein phosphorylation
C	0006513	biological_process	protein monoubiquitination
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
C	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
C	0007127	biological_process	meiosis I
C	0007131	biological_process	reciprocal meiotic recombination
C	0007140	biological_process	male meiotic nuclear division
C	0007143	biological_process	female meiotic nuclear division
C	0007165	biological_process	signal transduction
C	0007292	biological_process	female gamete generation
C	0007420	biological_process	brain development
C	0007507	biological_process	heart development
C	0008340	biological_process	determination of adult lifespan
C	0008585	biological_process	female gonad development
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0009791	biological_process	post-embryonic development
C	0010212	biological_process	response to ionizing radiation
C	0010468	biological_process	regulation of gene expression
C	0010506	biological_process	regulation of autophagy
C	0010557	biological_process	positive regulation of macromolecule biosynthetic process
C	0010628	biological_process	positive regulation of gene expression
C	0016301	molecular_function	kinase activity
C	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
C	0016740	molecular_function	transferase activity
C	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
C	0030335	biological_process	positive regulation of cell migration
C	0030889	biological_process	negative regulation of B cell proliferation
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031410	cellular_component	cytoplasmic vesicle
C	0032210	biological_process	regulation of telomere maintenance via telomerase
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0033151	biological_process	V(D)J recombination
C	0033554	biological_process	cellular response to stress
C	0034614	biological_process	cellular response to reactive oxygen species
C	0035264	biological_process	multicellular organism growth
C	0035861	cellular_component	site of double-strand break
C	0035979	molecular_function	histone H2AXS139 kinase activity
C	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
C	0036289	biological_process	peptidyl-serine autophosphorylation
C	0042159	biological_process	lipoprotein catabolic process
C	0042594	biological_process	response to starvation
C	0042770	biological_process	signal transduction in response to DNA damage
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0044877	molecular_function	protein-containing complex binding
C	0045141	biological_process	meiotic telomere clustering
C	0045785	biological_process	positive regulation of cell adhesion
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046777	biological_process	protein autophosphorylation
C	0048538	biological_process	thymus development
C	0048599	biological_process	oocyte development
C	0050821	biological_process	protein stabilization
C	0051402	biological_process	neuron apoptotic process
C	0051726	biological_process	regulation of cell cycle
C	0070192	biological_process	chromosome organization involved in meiotic cell cycle
C	0070534	biological_process	protein K63-linked ubiquitination
C	0071044	biological_process	histone mRNA catabolic process
C	0071300	biological_process	cellular response to retinoic acid
C	0071480	biological_process	cellular response to gamma radiation
C	0071481	biological_process	cellular response to X-ray
C	0071500	biological_process	cellular response to nitrosative stress
C	0080135	biological_process	regulation of cellular response to stress
C	0090398	biological_process	cellular senescence
C	0090399	biological_process	replicative senescence
C	0097694	biological_process	establishment of RNA localization to telomere
C	0097695	biological_process	establishment of protein-containing complex localization to telomere
C	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
C	0106310	molecular_function	protein serine kinase activity
C	0110025	biological_process	DNA strand resection involved in replication fork processing
C	1900034	biological_process	regulation of cellular response to heat
C	1901701	biological_process	cellular response to oxygen-containing compound
C	1901796	biological_process	regulation of signal transduction by p53 class mediator
C	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904354	biological_process	negative regulation of telomere capping
C	1904358	biological_process	positive regulation of telomere maintenance via telomere lengthening
C	1904884	biological_process	positive regulation of telomerase catalytic core complex assembly
C	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
C	1990166	biological_process	protein localization to site of double-strand break
C	1990391	cellular_component	DNA repair complex
C	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
C	2000781	biological_process	positive regulation of double-strand break repair
C	2000785	biological_process	regulation of autophagosome assembly
C	2000786	biological_process	positive regulation of autophagosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgr.DDLRQDavmqQ

Chain	Residue	Details
A	VAL2716-GLN2730

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SvAtssIvgYILgLgDRHvqN

Chain	Residue	Details
A	SER2855-ASN2875

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Region: {"description":"Interaction with ABL1","evidences":[{"source":"PubMed","id":"9168117","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Motif: {"description":"Microbody targeting signal; atypical","evidences":[{"source":"PubMed","id":"26344566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17923702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30944854","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	Motif: {"description":"FxF/Y motif","evidences":[{"source":"PubMed","id":"15758953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35076389","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---