7SFF
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3852279B
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00094 |
| Number of Residues | 13 |
| Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS |
| Chain | Residue | Details |
| A | GLU1218-SER1230 |
| site_id | PS00095 |
| Number of Residues | 19 |
| Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI |
| Chain | Residue | Details |
| A | ARG1574-ILE1592 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | ZN_FING: CXXC-type => ECO:0000255|PROSITE-ProRule:PRU00509 |
| Chain | Residue | Details |
| A | GLY982-HIS1028 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | THR1562 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | VAL750 | |
| A | ALA754 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 |
| Chain | Residue | Details |
| A | GLU989 | |
| A | ARG992 | |
| A | ARG995 | |
| A | PHE1000 | |
| A | LYS1003 | |
| A | ASN1006 | |
| A | TYR1022 | |
| A | THR1027 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P13864 |
| Chain | Residue | Details |
| A | GLY1482 | |
| A | ASP1486 | |
| A | THR1526 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PTA |
| Chain | Residue | Details |
| A | VAL1527 | |
| A | GLY1504 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Important for activity => ECO:0000250 |
| Chain | Residue | Details |
| A | MET845 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ARG730 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR885 | |
| A | LYS1214 | |
| A | VAL734 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P13864 |
| Chain | Residue | Details |
| A | MET845 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | VAL1050 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336 |
| Chain | Residue | Details |
| A | LEU1068 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21947282 |
| Chain | Residue | Details |
| A | GLN1227 | |
| A | GLN1293 | |
| A | GLY1297 | |
| A | ARG1311 | |
| A | GLY1390 | |
| A | PHE1085 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21947282, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | SER1447 | |
| A | GLY1449 | |
| A | MET1451 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by EHMT2 => ECO:0000269|PubMed:21947282 |
| Chain | Residue | Details |
| A | ARG1453 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P13864 |
| Chain | Residue | Details |
| A | TYR1457 | |
| A | LEU1455 |
