7SEC
Crystal structure of human Fibrillarin in complex with compound 1a
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00566 |
| Number of Residues | 15 |
| Details | FIBRILLARIN Fibrillarin signature. GLVYAVEFShRsgRD |
| Chain | Residue | Details |
| A | GLY185-ASP199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y9U3 |
| Chain | Residue | Details |
| A | THR172 | |
| B | THR172 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|Ref.31 |
| Chain | Residue | Details |
| B | ASP216 | |
| B | ASP236 | |
| A | GLU191 | |
| A | ASP216 | |
| A | ASP236 | |
| B | GLU191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30540930 |
| Chain | Residue | Details |
| A | LYS205 | |
| A | LYS206 | |
| B | LYS102 | |
| B | LYS121 | |
| B | LYS205 | |
| B | LYS206 | |
| A | LYS102 | |
| A | LYS121 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER126 | |
| A | SER116 | |
| B | SER116 | |
| B | SER126 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER124 | |
| B | SER124 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS84 | |
| A | LYS102 | |
| A | LYS109 | |
| A | LYS131 | |
| A | LYS143 | |
| A | LYS158 | |
| B | LYS84 | |
| B | LYS102 | |
| B | LYS109 | |
| B | LYS131 | |
| B | LYS143 | |
| B | LYS158 |
