7SAR

Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005886	cellular_component	plasma membrane
A	0007040	biological_process	lysosome organization
A	0007041	biological_process	lysosomal transport
A	0007042	biological_process	lysosomal lumen acidification
A	0031902	cellular_component	late endosome membrane
A	0032418	biological_process	lysosome localization
A	0048813	biological_process	dendrite morphogenesis
A	0051117	molecular_function	ATPase binding
A	0070050	biological_process	neuron cellular homeostasis
A	1900006	biological_process	positive regulation of dendrite development
A	1905146	biological_process	lysosomal protein catabolic process
A	1905671	biological_process	regulation of lysosome organization
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005768	cellular_component	endosome
B	0005886	cellular_component	plasma membrane
B	0007040	biological_process	lysosome organization
B	0007041	biological_process	lysosomal transport
B	0007042	biological_process	lysosomal lumen acidification
B	0031902	cellular_component	late endosome membrane
B	0032418	biological_process	lysosome localization
B	0048813	biological_process	dendrite morphogenesis
B	0051117	molecular_function	ATPase binding
B	0070050	biological_process	neuron cellular homeostasis
B	1900006	biological_process	positive regulation of dendrite development
B	1905146	biological_process	lysosomal protein catabolic process
B	1905671	biological_process	regulation of lysosome organization
C	0005515	molecular_function	protein binding
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005768	cellular_component	endosome
C	0005886	cellular_component	plasma membrane
C	0007040	biological_process	lysosome organization
C	0007041	biological_process	lysosomal transport
C	0007042	biological_process	lysosomal lumen acidification
C	0031902	cellular_component	late endosome membrane
C	0032418	biological_process	lysosome localization
C	0048813	biological_process	dendrite morphogenesis
C	0051117	molecular_function	ATPase binding
C	0070050	biological_process	neuron cellular homeostasis
C	1900006	biological_process	positive regulation of dendrite development
C	1905146	biological_process	lysosomal protein catabolic process
C	1905671	biological_process	regulation of lysosome organization
D	0005515	molecular_function	protein binding
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0005768	cellular_component	endosome
D	0005886	cellular_component	plasma membrane
D	0007040	biological_process	lysosome organization
D	0007041	biological_process	lysosomal transport
D	0007042	biological_process	lysosomal lumen acidification
D	0031902	cellular_component	late endosome membrane
D	0032418	biological_process	lysosome localization
D	0048813	biological_process	dendrite morphogenesis
D	0051117	molecular_function	ATPase binding
D	0070050	biological_process	neuron cellular homeostasis
D	1900006	biological_process	positive regulation of dendrite development
D	1905146	biological_process	lysosomal protein catabolic process
D	1905671	biological_process	regulation of lysosome organization
E	0005515	molecular_function	protein binding
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0005768	cellular_component	endosome
E	0005886	cellular_component	plasma membrane
E	0007040	biological_process	lysosome organization
E	0007041	biological_process	lysosomal transport
E	0007042	biological_process	lysosomal lumen acidification
E	0031902	cellular_component	late endosome membrane
E	0032418	biological_process	lysosome localization
E	0048813	biological_process	dendrite morphogenesis
E	0051117	molecular_function	ATPase binding
E	0070050	biological_process	neuron cellular homeostasis
E	1900006	biological_process	positive regulation of dendrite development
E	1905146	biological_process	lysosomal protein catabolic process
E	1905671	biological_process	regulation of lysosome organization
F	0005515	molecular_function	protein binding
F	0005764	cellular_component	lysosome
F	0005765	cellular_component	lysosomal membrane
F	0005768	cellular_component	endosome
F	0005886	cellular_component	plasma membrane
F	0007040	biological_process	lysosome organization
F	0007041	biological_process	lysosomal transport
F	0007042	biological_process	lysosomal lumen acidification
F	0031902	cellular_component	late endosome membrane
F	0032418	biological_process	lysosome localization
F	0048813	biological_process	dendrite morphogenesis
F	0051117	molecular_function	ATPase binding
F	0070050	biological_process	neuron cellular homeostasis
F	1900006	biological_process	positive regulation of dendrite development
F	1905146	biological_process	lysosomal protein catabolic process
F	1905671	biological_process	regulation of lysosome organization
G	0005515	molecular_function	protein binding
G	0005764	cellular_component	lysosome
G	0005765	cellular_component	lysosomal membrane
G	0005768	cellular_component	endosome
G	0005886	cellular_component	plasma membrane
G	0007040	biological_process	lysosome organization
G	0007041	biological_process	lysosomal transport
G	0007042	biological_process	lysosomal lumen acidification
G	0031902	cellular_component	late endosome membrane
G	0032418	biological_process	lysosome localization
G	0048813	biological_process	dendrite morphogenesis
G	0051117	molecular_function	ATPase binding
G	0070050	biological_process	neuron cellular homeostasis
G	1900006	biological_process	positive regulation of dendrite development
G	1905146	biological_process	lysosomal protein catabolic process
G	1905671	biological_process	regulation of lysosome organization
H	0005515	molecular_function	protein binding
H	0005764	cellular_component	lysosome
H	0005765	cellular_component	lysosomal membrane
H	0005768	cellular_component	endosome
H	0005886	cellular_component	plasma membrane
H	0007040	biological_process	lysosome organization
H	0007041	biological_process	lysosomal transport
H	0007042	biological_process	lysosomal lumen acidification
H	0031902	cellular_component	late endosome membrane
H	0032418	biological_process	lysosome localization
H	0048813	biological_process	dendrite morphogenesis
H	0051117	molecular_function	ATPase binding
H	0070050	biological_process	neuron cellular homeostasis
H	1900006	biological_process	positive regulation of dendrite development
H	1905146	biological_process	lysosomal protein catabolic process
H	1905671	biological_process	regulation of lysosome organization
I	0005515	molecular_function	protein binding
I	0005764	cellular_component	lysosome
I	0005765	cellular_component	lysosomal membrane
I	0005768	cellular_component	endosome
I	0005886	cellular_component	plasma membrane
I	0007040	biological_process	lysosome organization
I	0007041	biological_process	lysosomal transport
I	0007042	biological_process	lysosomal lumen acidification
I	0031902	cellular_component	late endosome membrane
I	0032418	biological_process	lysosome localization
I	0048813	biological_process	dendrite morphogenesis
I	0051117	molecular_function	ATPase binding
I	0070050	biological_process	neuron cellular homeostasis
I	1900006	biological_process	positive regulation of dendrite development
I	1905146	biological_process	lysosomal protein catabolic process
I	1905671	biological_process	regulation of lysosome organization
J	0005515	molecular_function	protein binding
J	0005764	cellular_component	lysosome
J	0005765	cellular_component	lysosomal membrane
J	0005768	cellular_component	endosome
J	0005886	cellular_component	plasma membrane
J	0007040	biological_process	lysosome organization
J	0007041	biological_process	lysosomal transport
J	0007042	biological_process	lysosomal lumen acidification
J	0031902	cellular_component	late endosome membrane
J	0032418	biological_process	lysosome localization
J	0048813	biological_process	dendrite morphogenesis
J	0051117	molecular_function	ATPase binding
J	0070050	biological_process	neuron cellular homeostasis
J	1900006	biological_process	positive regulation of dendrite development
J	1905146	biological_process	lysosomal protein catabolic process
J	1905671	biological_process	regulation of lysosome organization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22511793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22511793","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23742080","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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