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7SAR

Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0007040biological_processlysosome organization
A0007041biological_processlysosomal transport
A0007042biological_processlysosomal lumen acidification
A0031902cellular_componentlate endosome membrane
A0032418biological_processlysosome localization
A0048813biological_processdendrite morphogenesis
A0051117molecular_functionATPase binding
A0070050biological_processneuron cellular homeostasis
A1900006biological_processpositive regulation of dendrite development
A1905146biological_processlysosomal protein catabolic process
A1905671biological_processregulation of lysosome organization
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0007040biological_processlysosome organization
B0007041biological_processlysosomal transport
B0007042biological_processlysosomal lumen acidification
B0031902cellular_componentlate endosome membrane
B0032418biological_processlysosome localization
B0048813biological_processdendrite morphogenesis
B0051117molecular_functionATPase binding
B0070050biological_processneuron cellular homeostasis
B1900006biological_processpositive regulation of dendrite development
B1905146biological_processlysosomal protein catabolic process
B1905671biological_processregulation of lysosome organization
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0007040biological_processlysosome organization
C0007041biological_processlysosomal transport
C0007042biological_processlysosomal lumen acidification
C0031902cellular_componentlate endosome membrane
C0032418biological_processlysosome localization
C0048813biological_processdendrite morphogenesis
C0051117molecular_functionATPase binding
C0070050biological_processneuron cellular homeostasis
C1900006biological_processpositive regulation of dendrite development
C1905146biological_processlysosomal protein catabolic process
C1905671biological_processregulation of lysosome organization
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005886cellular_componentplasma membrane
D0007040biological_processlysosome organization
D0007041biological_processlysosomal transport
D0007042biological_processlysosomal lumen acidification
D0031902cellular_componentlate endosome membrane
D0032418biological_processlysosome localization
D0048813biological_processdendrite morphogenesis
D0051117molecular_functionATPase binding
D0070050biological_processneuron cellular homeostasis
D1900006biological_processpositive regulation of dendrite development
D1905146biological_processlysosomal protein catabolic process
D1905671biological_processregulation of lysosome organization
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005768cellular_componentendosome
E0005886cellular_componentplasma membrane
E0007040biological_processlysosome organization
E0007041biological_processlysosomal transport
E0007042biological_processlysosomal lumen acidification
E0031902cellular_componentlate endosome membrane
E0032418biological_processlysosome localization
E0048813biological_processdendrite morphogenesis
E0051117molecular_functionATPase binding
E0070050biological_processneuron cellular homeostasis
E1900006biological_processpositive regulation of dendrite development
E1905146biological_processlysosomal protein catabolic process
E1905671biological_processregulation of lysosome organization
F0003674molecular_functionmolecular_function
F0005515molecular_functionprotein binding
F0005764cellular_componentlysosome
F0005765cellular_componentlysosomal membrane
F0005768cellular_componentendosome
F0005886cellular_componentplasma membrane
F0007040biological_processlysosome organization
F0007041biological_processlysosomal transport
F0007042biological_processlysosomal lumen acidification
F0031902cellular_componentlate endosome membrane
F0032418biological_processlysosome localization
F0048813biological_processdendrite morphogenesis
F0051117molecular_functionATPase binding
F0070050biological_processneuron cellular homeostasis
F1900006biological_processpositive regulation of dendrite development
F1905146biological_processlysosomal protein catabolic process
F1905671biological_processregulation of lysosome organization
G0003674molecular_functionmolecular_function
G0005515molecular_functionprotein binding
G0005764cellular_componentlysosome
G0005765cellular_componentlysosomal membrane
G0005768cellular_componentendosome
G0005886cellular_componentplasma membrane
G0007040biological_processlysosome organization
G0007041biological_processlysosomal transport
G0007042biological_processlysosomal lumen acidification
G0031902cellular_componentlate endosome membrane
G0032418biological_processlysosome localization
G0048813biological_processdendrite morphogenesis
G0051117molecular_functionATPase binding
G0070050biological_processneuron cellular homeostasis
G1900006biological_processpositive regulation of dendrite development
G1905146biological_processlysosomal protein catabolic process
G1905671biological_processregulation of lysosome organization
H0003674molecular_functionmolecular_function
H0005515molecular_functionprotein binding
H0005764cellular_componentlysosome
H0005765cellular_componentlysosomal membrane
H0005768cellular_componentendosome
H0005886cellular_componentplasma membrane
H0007040biological_processlysosome organization
H0007041biological_processlysosomal transport
H0007042biological_processlysosomal lumen acidification
H0031902cellular_componentlate endosome membrane
H0032418biological_processlysosome localization
H0048813biological_processdendrite morphogenesis
H0051117molecular_functionATPase binding
H0070050biological_processneuron cellular homeostasis
H1900006biological_processpositive regulation of dendrite development
H1905146biological_processlysosomal protein catabolic process
H1905671biological_processregulation of lysosome organization
I0003674molecular_functionmolecular_function
I0005515molecular_functionprotein binding
I0005764cellular_componentlysosome
I0005765cellular_componentlysosomal membrane
I0005768cellular_componentendosome
I0005886cellular_componentplasma membrane
I0007040biological_processlysosome organization
I0007041biological_processlysosomal transport
I0007042biological_processlysosomal lumen acidification
I0031902cellular_componentlate endosome membrane
I0032418biological_processlysosome localization
I0048813biological_processdendrite morphogenesis
I0051117molecular_functionATPase binding
I0070050biological_processneuron cellular homeostasis
I1900006biological_processpositive regulation of dendrite development
I1905146biological_processlysosomal protein catabolic process
I1905671biological_processregulation of lysosome organization
J0003674molecular_functionmolecular_function
J0005515molecular_functionprotein binding
J0005764cellular_componentlysosome
J0005765cellular_componentlysosomal membrane
J0005768cellular_componentendosome
J0005886cellular_componentplasma membrane
J0007040biological_processlysosome organization
J0007041biological_processlysosomal transport
J0007042biological_processlysosomal lumen acidification
J0031902cellular_componentlate endosome membrane
J0032418biological_processlysosome localization
J0048813biological_processdendrite morphogenesis
J0051117molecular_functionATPase binding
J0070050biological_processneuron cellular homeostasis
J1900006biological_processpositive regulation of dendrite development
J1905146biological_processlysosomal protein catabolic process
J1905671biological_processregulation of lysosome organization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues940
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864
ChainResidueDetails
AGLY2-LEU96
JGLY2-LEU96
BGLY2-LEU96
CGLY2-LEU96
DGLY2-LEU96
EGLY2-LEU96
FGLY2-LEU96
GGLY2-LEU96
HGLY2-LEU96
IGLY2-LEU96

site_idSWS_FT_FI2
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATYR97-PHE117
JTYR97-PHE117
BTYR97-PHE117
CTYR97-PHE117
DTYR97-PHE117
ETYR97-PHE117
FTYR97-PHE117
GTYR97-PHE117
HTYR97-PHE117
ITYR97-PHE117

site_idSWS_FT_FI3
Number of Residues1560
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864
ChainResidueDetails
APRO118-GLN274
JPRO118-GLN274
BPRO118-GLN274
CPRO118-GLN274
DPRO118-GLN274
EPRO118-GLN274
FPRO118-GLN274
GPRO118-GLN274
HPRO118-GLN274
IPRO118-GLN274

site_idSWS_FT_FI4
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER33
JSER33
BSER33
CSER33
DSER33
ESER33
FSER33
GSER33
HSER33
ISER33

site_idSWS_FT_FI5
Number of Residues10
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805
ChainResidueDetails
AGLY2
JGLY2
BGLY2
CGLY2
DGLY2
EGLY2
FGLY2
GGLY2
HGLY2
IGLY2

site_idSWS_FT_FI6
Number of Residues40
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22511793
ChainResidueDetails
AASN145
CASN151
CASN164
CASN256
DASN145
DASN151
DASN164
DASN256
EASN145
EASN151
EASN164
AASN151
EASN256
FASN145
FASN151
FASN164
FASN256
GASN145
GASN151
GASN164
GASN256
HASN145
AASN164
HASN151
HASN164
HASN256
IASN145
IASN151
IASN164
IASN256
JASN145
JASN151
JASN164
AASN256
JASN256
BASN145
BASN151
BASN164
BASN256
CASN145

site_idSWS_FT_FI7
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23742080
ChainResidueDetails
AASN183
JASN183
BASN183
CASN183
DASN183
EASN183
FASN183
GASN183
HASN183
IASN183

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PDB entries from 2024-10-30

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