Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7S60

Human KATP channel in open conformation, focused on Kir and one SUR, position 4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001508biological_processaction potential
A0001666biological_processresponse to hypoxia
A0002931biological_processresponse to ischemia
A0003229biological_processventricular cardiac muscle tissue development
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006006biological_processglucose metabolic process
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006915biological_processapoptotic process
A0006950biological_processresponse to stress
A0008282cellular_componentinward rectifying potassium channel
A0008340biological_processdetermination of adult lifespan
A0009410biological_processresponse to xenobiotic stimulus
A0015272molecular_functionATP-activated inward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
A0030315cellular_componentT-tubule
A0030506molecular_functionankyrin binding
A0030955molecular_functionpotassium ion binding
A0031669biological_processcellular response to nutrient levels
A0032991cellular_componentprotein-containing complex
A0033198biological_processresponse to ATP
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034765biological_processregulation of monoatomic ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0044325molecular_functiontransmembrane transporter binding
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0050796biological_processregulation of insulin secretion
A0050877biological_processnervous system process
A0061762biological_processCAMKK-AMPK signaling cascade
A0071805biological_processpotassium ion transmembrane transport
A0098662biological_processinorganic cation transmembrane transport
A0099505biological_processregulation of presynaptic membrane potential
A0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1904638biological_processresponse to resveratrol
A1990573biological_processpotassium ion import across plasma membrane
B0000166molecular_functionnucleotide binding
B0001508biological_processaction potential
B0001666biological_processresponse to hypoxia
B0002931biological_processresponse to ischemia
B0003229biological_processventricular cardiac muscle tissue development
B0005242molecular_functioninward rectifier potassium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006006biological_processglucose metabolic process
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006915biological_processapoptotic process
B0006950biological_processresponse to stress
B0008282cellular_componentinward rectifying potassium channel
B0008340biological_processdetermination of adult lifespan
B0009410biological_processresponse to xenobiotic stimulus
B0015272molecular_functionATP-activated inward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
B0030315cellular_componentT-tubule
B0030506molecular_functionankyrin binding
B0030955molecular_functionpotassium ion binding
B0031669biological_processcellular response to nutrient levels
B0032991cellular_componentprotein-containing complex
B0033198biological_processresponse to ATP
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0034765biological_processregulation of monoatomic ion transmembrane transport
B0042391biological_processregulation of membrane potential
B0044325molecular_functiontransmembrane transporter binding
B0046676biological_processnegative regulation of insulin secretion
B0046872molecular_functionmetal ion binding
B0050796biological_processregulation of insulin secretion
B0050877biological_processnervous system process
B0061762biological_processCAMKK-AMPK signaling cascade
B0071805biological_processpotassium ion transmembrane transport
B0098662biological_processinorganic cation transmembrane transport
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1904638biological_processresponse to resveratrol
B1990573biological_processpotassium ion import across plasma membrane
C0000166molecular_functionnucleotide binding
C0001508biological_processaction potential
C0001666biological_processresponse to hypoxia
C0002931biological_processresponse to ischemia
C0003229biological_processventricular cardiac muscle tissue development
C0005242molecular_functioninward rectifier potassium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006006biological_processglucose metabolic process
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006915biological_processapoptotic process
C0006950biological_processresponse to stress
C0008282cellular_componentinward rectifying potassium channel
C0008340biological_processdetermination of adult lifespan
C0009410biological_processresponse to xenobiotic stimulus
C0015272molecular_functionATP-activated inward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
C0030315cellular_componentT-tubule
C0030506molecular_functionankyrin binding
C0030955molecular_functionpotassium ion binding
C0031669biological_processcellular response to nutrient levels
C0032991cellular_componentprotein-containing complex
C0033198biological_processresponse to ATP
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034765biological_processregulation of monoatomic ion transmembrane transport
C0042391biological_processregulation of membrane potential
C0044325molecular_functiontransmembrane transporter binding
C0046676biological_processnegative regulation of insulin secretion
C0046872molecular_functionmetal ion binding
C0050796biological_processregulation of insulin secretion
C0050877biological_processnervous system process
C0061762biological_processCAMKK-AMPK signaling cascade
C0071805biological_processpotassium ion transmembrane transport
C0098662biological_processinorganic cation transmembrane transport
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1904638biological_processresponse to resveratrol
C1990573biological_processpotassium ion import across plasma membrane
D0000166molecular_functionnucleotide binding
D0001508biological_processaction potential
D0001666biological_processresponse to hypoxia
D0002931biological_processresponse to ischemia
D0003229biological_processventricular cardiac muscle tissue development
D0005242molecular_functioninward rectifier potassium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006006biological_processglucose metabolic process
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006915biological_processapoptotic process
D0006950biological_processresponse to stress
D0008282cellular_componentinward rectifying potassium channel
D0008340biological_processdetermination of adult lifespan
D0009410biological_processresponse to xenobiotic stimulus
D0015272molecular_functionATP-activated inward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
D0030315cellular_componentT-tubule
D0030506molecular_functionankyrin binding
D0030955molecular_functionpotassium ion binding
D0031669biological_processcellular response to nutrient levels
D0032991cellular_componentprotein-containing complex
D0033198biological_processresponse to ATP
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0034765biological_processregulation of monoatomic ion transmembrane transport
D0042391biological_processregulation of membrane potential
D0044325molecular_functiontransmembrane transporter binding
D0046676biological_processnegative regulation of insulin secretion
D0046872molecular_functionmetal ion binding
D0050796biological_processregulation of insulin secretion
D0050877biological_processnervous system process
D0061762biological_processCAMKK-AMPK signaling cascade
D0071805biological_processpotassium ion transmembrane transport
D0098662biological_processinorganic cation transmembrane transport
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1904638biological_processresponse to resveratrol
D1990573biological_processpotassium ion import across plasma membrane
E0000166molecular_functionnucleotide binding
E0001508biological_processaction potential
E0001678biological_processintracellular glucose homeostasis
E0005267molecular_functionpotassium channel activity
E0005524molecular_functionATP binding
E0005886cellular_componentplasma membrane
E0006813biological_processpotassium ion transport
E0007565biological_processfemale pregnancy
E0007613biological_processmemory
E0008281molecular_functionsulfonylurea receptor activity
E0008282cellular_componentinward rectifying potassium channel
E0008542biological_processvisual learning
E0009268biological_processresponse to pH
E0009410biological_processresponse to xenobiotic stimulus
E0010043biological_processresponse to zinc ion
E0010989biological_processnegative regulation of low-density lipoprotein particle clearance
E0015272molecular_functionATP-activated inward rectifier potassium channel activity
E0016020cellular_componentmembrane
E0016525biological_processnegative regulation of angiogenesis
E0016887molecular_functionATP hydrolysis activity
E0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
E0030672cellular_componentsynaptic vesicle membrane
E0031004cellular_componentpotassium ion-transporting ATPase complex
E0031669biological_processcellular response to nutrient levels
E0032496biological_processresponse to lipopolysaccharide
E0032760biological_processpositive regulation of tumor necrosis factor production
E0032868biological_processresponse to insulin
E0032991cellular_componentprotein-containing complex
E0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
E0042383cellular_componentsarcolemma
E0042734cellular_componentpresynaptic membrane
E0043268biological_processpositive regulation of potassium ion transport
E0043531molecular_functionADP binding
E0044325molecular_functiontransmembrane transporter binding
E0046676biological_processnegative regulation of insulin secretion
E0046872molecular_functionmetal ion binding
E0050768biological_processnegative regulation of neurogenesis
E0050905biological_processneuromuscular process
E0055085biological_processtransmembrane transport
E0060253biological_processnegative regulation of glial cell proliferation
E0061535biological_processglutamate secretion, neurotransmission
E0061855biological_processnegative regulation of neuroblast migration
E0071805biological_processpotassium ion transmembrane transport
E0098662biological_processinorganic cation transmembrane transport
E0140359molecular_functionABC-type transporter activity
E1900721biological_processpositive regulation of uterine smooth muscle relaxation
E1905075biological_processpositive regulation of tight junction disassembly
E1905604biological_processnegative regulation of blood-brain barrier permeability
E1990573biological_processpotassium ion import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL
ChainResidueDetails
ELEU830-LEU844
EPHE1482-PHE1496
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI4
Number of Residues4
DetailsSite: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues104
DetailsTransmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues124
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues64
DetailsIntramembrane: {"description":"Discontinuously helical; Pore-forming","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues112
DetailsTransmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P70673","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine; by MAPK1","evidences":[{"source":"PubMed","id":"18280666","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues583
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues70
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues15
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues15
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues15
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues12
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues15
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues15
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues12
DetailsTransmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues15
DetailsTransmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues15
DetailsTransmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues234
DetailsDomain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"Q09427","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

PDB statisticsPDBj update infoContact PDBjnumon