7S5V
Human KATP channel in open conformation, focused on SUR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0001508 | biological_process | action potential |
| E | 0001678 | biological_process | intracellular glucose homeostasis |
| E | 0005267 | molecular_function | potassium channel activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006813 | biological_process | potassium ion transport |
| E | 0007565 | biological_process | female pregnancy |
| E | 0007613 | biological_process | memory |
| E | 0008281 | molecular_function | sulfonylurea receptor activity |
| E | 0008282 | cellular_component | inward rectifying potassium channel |
| E | 0008542 | biological_process | visual learning |
| E | 0009268 | biological_process | response to pH |
| E | 0009410 | biological_process | response to xenobiotic stimulus |
| E | 0010043 | biological_process | response to zinc ion |
| E | 0010989 | biological_process | negative regulation of low-density lipoprotein particle clearance |
| E | 0015272 | molecular_function | ATP-activated inward rectifier potassium channel activity |
| E | 0016020 | cellular_component | membrane |
| E | 0016525 | biological_process | negative regulation of angiogenesis |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0019829 | molecular_function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| E | 0030672 | cellular_component | synaptic vesicle membrane |
| E | 0031004 | cellular_component | potassium ion-transporting ATPase complex |
| E | 0031669 | biological_process | cellular response to nutrient levels |
| E | 0032496 | biological_process | response to lipopolysaccharide |
| E | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| E | 0032868 | biological_process | response to insulin |
| E | 0032991 | cellular_component | protein-containing complex |
| E | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| E | 0042383 | cellular_component | sarcolemma |
| E | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| E | 0042734 | cellular_component | presynaptic membrane |
| E | 0043268 | biological_process | positive regulation of potassium ion transport |
| E | 0043531 | molecular_function | ADP binding |
| E | 0044325 | molecular_function | transmembrane transporter binding |
| E | 0046676 | biological_process | negative regulation of insulin secretion |
| E | 0050768 | biological_process | negative regulation of neurogenesis |
| E | 0050905 | biological_process | neuromuscular process |
| E | 0055085 | biological_process | transmembrane transport |
| E | 0060253 | biological_process | negative regulation of glial cell proliferation |
| E | 0061535 | biological_process | glutamate secretion, neurotransmission |
| E | 0061855 | biological_process | negative regulation of neuroblast migration |
| E | 0071805 | biological_process | potassium ion transmembrane transport |
| E | 0098662 | biological_process | inorganic cation transmembrane transport |
| E | 0140359 | molecular_function | ABC-type transporter activity |
| E | 1900721 | biological_process | positive regulation of uterine smooth muscle relaxation |
| E | 1905075 | biological_process | positive regulation of tight junction disassembly |
| E | 1905604 | biological_process | negative regulation of blood-brain barrier permeability |
| E | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL |
| Chain | Residue | Details |
| E | LEU830-LEU844 | |
| E | PHE1482-PHE1496 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | PRO36-SER56 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1058 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| E | SER57-TRP76 | |
| E | TYR124-LYS135 | |
| E | TYR196-LEU312 | |
| E | TYR378-LEU435 | |
| E | LYS481-SER542 | |
| E | SER607-LEU1005 | |
| E | LYS1095-SER1138 | |
| E | PHE1182-MET1252 | |
| E | VAL1299-LYS1582 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | ILE77-ASP97 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 112 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| E | GLY98-SER102 | |
| E | VAL156-LEU168 | |
| E | ASP333-ALA356 | |
| E | LEU457-VAL459 | |
| E | VAL564-HIS585 | |
| E | LEU1027-SER1073 | |
| E | VAL1160 | |
| E | ARG1274-SER1277 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | HIS103-VAL123 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | LEU136-PHE155 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | ARG169-ARG195 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | LEU313-ASN332 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | TYR357-SER377 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | CYS436-ILE456 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | SER460-THR480 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | ILE543-HIS563 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | ILE586-VAL606 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | SER1006-VAL1026 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | LEU1074-ALA1094 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | THR1139-TYR1159 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | THR1161-TYR1181 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | GLU1253-HIS1273 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=17 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| E | ALA1278-MET1298 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| E | GLY714 | |
| E | GLY1379 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250 |
| Chain | Residue | Details |
| E | ASN11 | |
| E | ASN1050 |
