Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7S5T

Human KATP channel in open conformation, focused on Kir (C166S G334D double mutant) and SUR TMD0

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006006biological_processglucose metabolic process
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008282cellular_componentinward rectifying potassium channel
A0009410biological_processresponse to xenobiotic stimulus
A0015272molecular_functionATP-activated inward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
A0030315cellular_componentT-tubule
A0030506molecular_functionankyrin binding
A0030955molecular_functionpotassium ion binding
A0032991cellular_componentprotein-containing complex
A0033198biological_processresponse to ATP
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0042391biological_processregulation of membrane potential
A0044325molecular_functiontransmembrane transporter binding
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0050796biological_processregulation of insulin secretion
A0050877biological_processnervous system process
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0098659biological_processinorganic cation import across plasma membrane
A0099505biological_processregulation of presynaptic membrane potential
A0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1990573biological_processpotassium ion import across plasma membrane
B0000166molecular_functionnucleotide binding
B0005242molecular_functioninward rectifier potassium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006006biological_processglucose metabolic process
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008282cellular_componentinward rectifying potassium channel
B0009410biological_processresponse to xenobiotic stimulus
B0015272molecular_functionATP-activated inward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
B0030315cellular_componentT-tubule
B0030506molecular_functionankyrin binding
B0030955molecular_functionpotassium ion binding
B0032991cellular_componentprotein-containing complex
B0033198biological_processresponse to ATP
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0042391biological_processregulation of membrane potential
B0044325molecular_functiontransmembrane transporter binding
B0046676biological_processnegative regulation of insulin secretion
B0046872molecular_functionmetal ion binding
B0050796biological_processregulation of insulin secretion
B0050877biological_processnervous system process
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0098659biological_processinorganic cation import across plasma membrane
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1990573biological_processpotassium ion import across plasma membrane
C0000166molecular_functionnucleotide binding
C0005242molecular_functioninward rectifier potassium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006006biological_processglucose metabolic process
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008282cellular_componentinward rectifying potassium channel
C0009410biological_processresponse to xenobiotic stimulus
C0015272molecular_functionATP-activated inward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
C0030315cellular_componentT-tubule
C0030506molecular_functionankyrin binding
C0030955molecular_functionpotassium ion binding
C0032991cellular_componentprotein-containing complex
C0033198biological_processresponse to ATP
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0042391biological_processregulation of membrane potential
C0044325molecular_functiontransmembrane transporter binding
C0046676biological_processnegative regulation of insulin secretion
C0046872molecular_functionmetal ion binding
C0050796biological_processregulation of insulin secretion
C0050877biological_processnervous system process
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0098659biological_processinorganic cation import across plasma membrane
C0099505biological_processregulation of presynaptic membrane potential
C0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1990573biological_processpotassium ion import across plasma membrane
D0000166molecular_functionnucleotide binding
D0005242molecular_functioninward rectifier potassium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006006biological_processglucose metabolic process
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008282cellular_componentinward rectifying potassium channel
D0009410biological_processresponse to xenobiotic stimulus
D0015272molecular_functionATP-activated inward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
D0030315cellular_componentT-tubule
D0030506molecular_functionankyrin binding
D0030955molecular_functionpotassium ion binding
D0032991cellular_componentprotein-containing complex
D0033198biological_processresponse to ATP
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0042391biological_processregulation of membrane potential
D0044325molecular_functiontransmembrane transporter binding
D0046676biological_processnegative regulation of insulin secretion
D0046872molecular_functionmetal ion binding
D0050796biological_processregulation of insulin secretion
D0050877biological_processnervous system process
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
D0098659biological_processinorganic cation import across plasma membrane
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI4
Number of Residues4
DetailsSite: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues104
DetailsTransmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues124
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues64
DetailsIntramembrane: {"description":"Discontinuously helical; Pore-forming","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues112
DetailsTransmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P70673","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine; by MAPK1","evidences":[{"source":"PubMed","id":"18280666","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

PDB statisticsPDBj update infoContact PDBjnumon