7S5A

Crystal structure of human chemokine CCL8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002687	biological_process	positive regulation of leukocyte migration
A	0004672	molecular_function	protein kinase activity
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0006887	biological_process	exocytosis
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0008009	molecular_function	chemokine activity
A	0008201	molecular_function	heparin binding
A	0009615	biological_process	response to virus
A	0016004	molecular_function	phospholipase activator activity
A	0030335	biological_process	positive regulation of cell migration
A	0044828	biological_process	host-mediated suppression of viral genome replication
A	0048020	molecular_function	CCR chemokine receptor binding
A	0048245	biological_process	eosinophil chemotaxis
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0070098	biological_process	chemokine-mediated signaling pathway
A	0070664	biological_process	negative regulation of leukocyte proliferation
B	0002687	biological_process	positive regulation of leukocyte migration
B	0004672	molecular_function	protein kinase activity
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0006887	biological_process	exocytosis
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0008009	molecular_function	chemokine activity
B	0008201	molecular_function	heparin binding
B	0009615	biological_process	response to virus
B	0016004	molecular_function	phospholipase activator activity
B	0030335	biological_process	positive regulation of cell migration
B	0044828	biological_process	host-mediated suppression of viral genome replication
B	0048020	molecular_function	CCR chemokine receptor binding
B	0048245	biological_process	eosinophil chemotaxis
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0070098	biological_process	chemokine-mediated signaling pathway
B	0070664	biological_process	negative regulation of leukocyte proliferation

Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	43
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFnvinrk..IpiqrLesYtritniq.Cpke.AVIFktqrgkev.CA

Chain	Residue	Details
A	CYS11-ALA53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"11087354","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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