7S4N

Crystal structure of the tick evasin EVA-P974 complexed to human chemokine CCL17

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0019957	molecular_function	C-C chemokine binding
A	1900137	biological_process	negative regulation of chemokine activity
B	0005102	molecular_function	signaling receptor binding
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007267	biological_process	cell-cell signaling
B	0008009	molecular_function	chemokine activity
B	0030335	biological_process	positive regulation of cell migration
B	0048020	molecular_function	CCR chemokine receptor binding
B	0060326	biological_process	cell chemotaxis
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0070098	biological_process	chemokine-mediated signaling pathway
C	0019957	molecular_function	C-C chemokine binding
C	1900137	biological_process	negative regulation of chemokine activity
D	0005102	molecular_function	signaling receptor binding
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006935	biological_process	chemotaxis
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007267	biological_process	cell-cell signaling
D	0008009	molecular_function	chemokine activity
D	0030335	biological_process	positive regulation of cell migration
D	0048020	molecular_function	CCR chemokine receptor binding
D	0060326	biological_process	cell chemotaxis
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0070098	biological_process	chemokine-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	42
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLeyfkga..IplrkLktWyqtsed..Csrd.AIVFvtvqgrai.CS

Chain	Residue	Details
D	CYS10-SER51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	ASN16
C	ASN16

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