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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7S24

Crystal structure of the Na+/H+ antiporter NhaA at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006814	biological_process	sodium ion transport
A	0006885	biological_process	regulation of pH
A	0009651	biological_process	response to salt stress
A	0010446	biological_process	response to alkaline pH
A	0015081	molecular_function	sodium ion transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015385	molecular_function	sodium:proton antiporter activity
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0051453	biological_process	regulation of intracellular pH
A	0055085	biological_process	transmembrane transport
A	1901612	molecular_function	cardiolipin binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	95
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	MET1-ASP11
A	ARG81-PHE96
A	ALA131-ILE154
A	GLY201-ARG204
A	ILE237-HIS253
A	ALA311-PHE339

site_id	SWS_FT_FI2
Number of Residues	19
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	ALA12-SER31

site_id	SWS_FT_FI3
Number of Residues	54
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	GLY32-ASN58
A	TYR117-THR122
A	ASN177-SER180
A	GLY223
A	GLY273-SER286
A	GLY351-LEU357

site_id	SWS_FT_FI4
Number of Residues	21
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	MET59-LYS80

site_id	SWS_FT_FI5
Number of Residues	19
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	PRO97-ASN116

site_id	SWS_FT_FI6
Number of Residues	7
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	ARG123-ALA130

site_id	SWS_FT_FI7
Number of Residues	21
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	PHE155-THR176

site_id	SWS_FT_FI8
Number of Residues	19
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	MET181-CYS200

site_id	SWS_FT_FI9
Number of Residues	17
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	THR205-SER222

site_id	SWS_FT_FI10
Number of Residues	12
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	VAL224-PHE236

site_id	SWS_FT_FI11
Number of Residues	18
Details	TRANSMEM: Helical; Name=9 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	VAL254-ALA272

site_id	SWS_FT_FI12
Number of Residues	23
Details	TRANSMEM: Helical; Name=10 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	ILE287-LEU310

site_id	SWS_FT_FI13
Number of Residues	10
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	THR340-PHE350

site_id	SWS_FT_FI14
Number of Residues	22
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	ILE358-LEU380

site_id	SWS_FT_FI15
Number of Residues	7
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996, ECO:0000269\|PubMed:25422503, ECO:0007744\|PDB:4ATV, ECO:0007744\|PDB:4AU5

Chain	Residue	Details
A	ARG381-VAL388

site_id	SWS_FT_FI16
Number of Residues	1
Details	SITE: Important for stability, cation binding and translocation => ECO:0000305\|PubMed:15988517, ECO:0000305\|PubMed:22915592, ECO:0000305\|PubMed:27021484, ECO:0000305\|PubMed:29410365, ECO:0000305\|PubMed:7737413

Chain	Residue	Details
A	ASP133

site_id	SWS_FT_FI17
Number of Residues	1
Details	SITE: Essential for cation binding and translocation => ECO:0000305\|PubMed:15988517, ECO:0000305\|PubMed:19274728, ECO:0000305\|PubMed:22915592, ECO:0000305\|PubMed:25422503, ECO:0000305\|PubMed:27021484, ECO:0000305\|PubMed:27708266, ECO:0000305\|PubMed:30409911, ECO:0000305\|PubMed:7737413

Chain	Residue	Details
A	ASP163

site_id	SWS_FT_FI18
Number of Residues	1
Details	SITE: Essential for cation binding and translocation => ECO:0000305\|PubMed:15988517, ECO:0000305\|PubMed:19274728, ECO:0000305\|PubMed:22915592, ECO:0000305\|PubMed:25422503, ECO:0000305\|PubMed:27021484, ECO:0000305\|PubMed:27708266, ECO:0000305\|PubMed:7737413

Chain	Residue	Details
A	ASP164

site_id	SWS_FT_FI19
Number of Residues	2
Details	SITE: Important for pH response => ECO:0000305\|PubMed:10455127

Chain	Residue	Details
A	GLU241
A	VAL254

site_id	SWS_FT_FI20
Number of Residues	1
Details	SITE: Important for pH response => ECO:0000305\|PubMed:14604993

Chain	Residue	Details
A	GLU252

site_id	SWS_FT_FI21
Number of Residues	1
Details	SITE: Important for stability and activity => ECO:0000305\|PubMed:15988517, ECO:0000305\|PubMed:22915592, ECO:0000305\|PubMed:25422503, ECO:0000305\|PubMed:27708266, ECO:0000305\|PubMed:28330875, ECO:0000305\|PubMed:30409911

Chain	Residue	Details
A	LYS300

221051

PDB entries from 2024-06-12

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