7S0Y
Structures of TcdB in complex with Cdc42
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000322 | cellular_component | storage vacuole |
| B | 0001669 | cellular_component | acrosomal vesicle |
| B | 0003015 | biological_process | heart process |
| B | 0003253 | biological_process | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005813 | cellular_component | centrosome |
| B | 0005819 | cellular_component | spindle |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005911 | cellular_component | cell-cell junction |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006897 | biological_process | endocytosis |
| B | 0006911 | biological_process | phagocytosis, engulfment |
| B | 0007015 | biological_process | actin filament organization |
| B | 0007030 | biological_process | Golgi organization |
| B | 0007163 | biological_process | establishment or maintenance of cell polarity |
| B | 0007229 | biological_process | integrin-mediated signaling pathway |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0009653 | biological_process | anatomical structure morphogenesis |
| B | 0010591 | biological_process | regulation of lamellipodium assembly |
| B | 0010592 | biological_process | positive regulation of lamellipodium assembly |
| B | 0015630 | cellular_component | microtubule cytoskeleton |
| B | 0016020 | cellular_component | membrane |
| B | 0017119 | cellular_component | COG complex |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0021762 | biological_process | substantia nigra development |
| B | 0030010 | biological_process | establishment of cell polarity |
| B | 0030036 | biological_process | actin cytoskeleton organization |
| B | 0030175 | cellular_component | filopodium |
| B | 0030225 | biological_process | macrophage differentiation |
| B | 0030307 | biological_process | positive regulation of cell growth |
| B | 0030335 | biological_process | positive regulation of cell migration |
| B | 0030425 | cellular_component | dendrite |
| B | 0030496 | cellular_component | midbody |
| B | 0030742 | molecular_function | GTP-dependent protein binding |
| B | 0031252 | cellular_component | cell leading edge |
| B | 0031256 | cellular_component | leading edge membrane |
| B | 0031274 | biological_process | positive regulation of pseudopodium assembly |
| B | 0031333 | biological_process | negative regulation of protein-containing complex assembly |
| B | 0031996 | molecular_function | thioesterase binding |
| B | 0032427 | molecular_function | GBD domain binding |
| B | 0032467 | biological_process | positive regulation of cytokinesis |
| B | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0034191 | molecular_function | apolipoprotein A-I receptor binding |
| B | 0034329 | biological_process | cell junction assembly |
| B | 0035050 | biological_process | embryonic heart tube development |
| B | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| B | 0038189 | biological_process | neuropilin signaling pathway |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0044788 | biological_process | host-mediated perturbation of viral process |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0045198 | biological_process | establishment of epithelial cell apical/basal polarity |
| B | 0045335 | cellular_component | phagocytic vesicle |
| B | 0048549 | biological_process | positive regulation of pinocytosis |
| B | 0051130 | biological_process | positive regulation of cellular component organization |
| B | 0051233 | cellular_component | spindle midzone |
| B | 0051489 | biological_process | regulation of filopodium assembly |
| B | 0051491 | biological_process | positive regulation of filopodium assembly |
| B | 0051492 | biological_process | regulation of stress fiber assembly |
| B | 0051496 | biological_process | positive regulation of stress fiber assembly |
| B | 0051683 | biological_process | establishment of Golgi localization |
| B | 0051988 | biological_process | regulation of attachment of spindle microtubules to kinetochore |
| B | 0060071 | biological_process | Wnt signaling pathway, planar cell polarity pathway |
| B | 0060501 | biological_process | positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| B | 0060997 | biological_process | dendritic spine morphogenesis |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071944 | cellular_component | cell periphery |
| B | 0072384 | biological_process | organelle transport along microtubule |
| B | 0072686 | cellular_component | mitotic spindle |
| B | 0086100 | biological_process | endothelin receptor signaling pathway |
| B | 0098794 | cellular_component | postsynapse |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099175 | biological_process | regulation of postsynapse organization |
| B | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Domain: {"description":"GT44","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 89 |
| Details | Region: {"description":"Four-helical bundle","evidences":[{"source":"PubMed","id":"25882477","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 372 |
| Details | Region: {"description":"Glucosyltransferase region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16054646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OQ7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16054646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6OQ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16054646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OQ7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622875","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"14506284","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
