7RXC
CryoEM structure of KDELR with Legobody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005618 | cellular_component | cell wall |
| B | 0008643 | biological_process | carbohydrate transport |
| B | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| B | 0019865 | molecular_function | immunoglobulin binding |
| B | 0055085 | biological_process | transmembrane transport |
| K | 0000139 | cellular_component | Golgi membrane |
| K | 0005046 | molecular_function | KDEL sequence binding |
| K | 0005783 | cellular_component | endoplasmic reticulum |
| K | 0005789 | cellular_component | endoplasmic reticulum membrane |
| K | 0005794 | cellular_component | Golgi apparatus |
| K | 0005801 | cellular_component | cis-Golgi network |
| K | 0006621 | biological_process | protein retention in ER lumen |
| K | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| K | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| K | 0015031 | biological_process | protein transport |
| K | 0016020 | cellular_component | membrane |
| K | 0016192 | biological_process | vesicle-mediated transport |
| K | 0030663 | cellular_component | COPI-coated vesicle membrane |
| K | 0031410 | cellular_component | cytoplasmic vesicle |
| K | 0035437 | biological_process | maintenance of protein localization in endoplasmic reticulum |
| K | 0046923 | molecular_function | ER retention sequence binding |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| H | TYR204-HIS210 | |
| L | TYR197-HIS203 |
| site_id | PS00951 |
| Number of Residues | 18 |
| Details | ER_LUMEN_RECEPTOR_1 ER lumen protein retaining receptor signature 1. GISgKsQlLFaLVFttRY |
| Chain | Residue | Details |
| K | GLY31-TYR48 |
| site_id | PS00952 |
| Number of Residues | 10 |
| Details | ER_LUMEN_RECEPTOR_2 ER lumen protein retaining receptor signature 2. LESVAILPQL |
| Chain | Residue | Details |
| K | LEU126-LEU135 |
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| B | PRO108-ASN125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:30846601 |
| Chain | Residue | Details |
| K | MET1-PHE4 | |
| K | THR53-LEU58 | |
| K | HIS111-LEU116 | |
| K | ARG169-LEU178 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 131 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30846601 |
| Chain | Residue | Details |
| K | ARG5-TRP24 | |
| K | SER33-PHE52 | |
| K | TYR59-TYR79 | |
| K | PHE93-ASN110 | |
| K | GLU117-LEU135 | |
| K | HIS150-TRP168 | |
| K | ILE179-VAL199 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30846601 |
| Chain | Residue | Details |
| K | LYS25-ILE32 | |
| K | MET80-THR92 | |
| K | PHE136-THR149 | |
| K | THR200-ALA212 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Interaction with the K-D-E-L motif on target proteins => ECO:0000269|PubMed:30846601 |
| Chain | Residue | Details |
| K | ARG5 | |
| K | SER54 | |
| K | GLU117 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum => ECO:0000250|UniProtKB:P24390 |
| Chain | Residue | Details |
| K | ASP193 |
