Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7RWB

AP2 bound to the APA domain of SGIP in the presence of heparin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030121	cellular_component	AP-1 adaptor complex
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
M	0002092	biological_process	positive regulation of receptor internalization
M	0005048	molecular_function	signal sequence binding
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005886	cellular_component	plasma membrane
M	0005905	cellular_component	clathrin-coated pit
M	0006886	biological_process	intracellular protein transport
M	0006897	biological_process	endocytosis
M	0006900	biological_process	vesicle budding from membrane
M	0008021	cellular_component	synaptic vesicle
M	0008289	molecular_function	lipid binding
M	0009898	cellular_component	cytoplasmic side of plasma membrane
M	0015031	biological_process	protein transport
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
M	0030122	cellular_component	AP-2 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0030141	cellular_component	secretory granule
M	0031410	cellular_component	cytoplasmic vesicle
M	0031623	biological_process	receptor internalization
M	0035615	molecular_function	clathrin adaptor activity
M	0044325	molecular_function	transmembrane transporter binding
M	0045202	cellular_component	synapse
M	0048488	biological_process	synaptic vesicle endocytosis
M	0050750	molecular_function	low-density lipoprotein particle receptor binding
M	0065003	biological_process	protein-containing complex assembly
M	0072583	biological_process	clathrin-dependent endocytosis
M	0097494	biological_process	regulation of vesicle size
M	0097718	molecular_function	disordered domain specific binding
M	0098794	cellular_component	postsynapse
M	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
M	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
M	0098978	cellular_component	glutamatergic synapse
M	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
M	1903077	biological_process	negative regulation of protein localization to plasma membrane
S	0005515	molecular_function	protein binding
S	0005886	cellular_component	plasma membrane
S	0005905	cellular_component	clathrin-coated pit
S	0006886	biological_process	intracellular protein transport
S	0006897	biological_process	endocytosis
S	0009898	cellular_component	cytoplasmic side of plasma membrane
S	0015031	biological_process	protein transport
S	0016020	cellular_component	membrane
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030122	cellular_component	AP-2 adaptor complex
S	0035615	molecular_function	clathrin adaptor activity
S	0045202	cellular_component	synapse
S	0048488	biological_process	synaptic vesicle endocytosis
S	0072583	biological_process	clathrin-dependent endocytosis
S	0098793	cellular_component	presynapse
S	0098794	cellular_component	postsynapse
S	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
a	0005794	cellular_component	Golgi apparatus
a	0006886	biological_process	intracellular protein transport
a	0016192	biological_process	vesicle-mediated transport
a	0030117	cellular_component	membrane coat
a	0030121	cellular_component	AP-1 adaptor complex
b	0006886	biological_process	intracellular protein transport
b	0015031	biological_process	protein transport
b	0016192	biological_process	vesicle-mediated transport
b	0030117	cellular_component	membrane coat
b	0030276	molecular_function	clathrin binding
m	0002092	biological_process	positive regulation of receptor internalization
m	0005048	molecular_function	signal sequence binding
m	0005515	molecular_function	protein binding
m	0005739	cellular_component	mitochondrion
m	0005886	cellular_component	plasma membrane
m	0005905	cellular_component	clathrin-coated pit
m	0006886	biological_process	intracellular protein transport
m	0006897	biological_process	endocytosis
m	0006900	biological_process	vesicle budding from membrane
m	0008021	cellular_component	synaptic vesicle
m	0008289	molecular_function	lipid binding
m	0009898	cellular_component	cytoplasmic side of plasma membrane
m	0015031	biological_process	protein transport
m	0016020	cellular_component	membrane
m	0016192	biological_process	vesicle-mediated transport
m	0030122	cellular_component	AP-2 adaptor complex
m	0030131	cellular_component	clathrin adaptor complex
m	0030141	cellular_component	secretory granule
m	0031410	cellular_component	cytoplasmic vesicle
m	0031623	biological_process	receptor internalization
m	0035615	molecular_function	clathrin adaptor activity
m	0044325	molecular_function	transmembrane transporter binding
m	0045202	cellular_component	synapse
m	0048488	biological_process	synaptic vesicle endocytosis
m	0050750	molecular_function	low-density lipoprotein particle receptor binding
m	0065003	biological_process	protein-containing complex assembly
m	0072583	biological_process	clathrin-dependent endocytosis
m	0097494	biological_process	regulation of vesicle size
m	0097718	molecular_function	disordered domain specific binding
m	0098794	cellular_component	postsynapse
m	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
m	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
m	0098978	cellular_component	glutamatergic synapse
m	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
m	1903077	biological_process	negative regulation of protein localization to plasma membrane
s	0005515	molecular_function	protein binding
s	0005886	cellular_component	plasma membrane
s	0005905	cellular_component	clathrin-coated pit
s	0006886	biological_process	intracellular protein transport
s	0006897	biological_process	endocytosis
s	0009898	cellular_component	cytoplasmic side of plasma membrane
s	0015031	biological_process	protein transport
s	0016020	cellular_component	membrane
s	0016192	biological_process	vesicle-mediated transport
s	0030117	cellular_component	membrane coat
s	0030122	cellular_component	AP-2 adaptor complex
s	0035615	molecular_function	clathrin adaptor activity
s	0045202	cellular_component	synapse
s	0048488	biological_process	synaptic vesicle endocytosis
s	0072583	biological_process	clathrin-dependent endocytosis
s	0098793	cellular_component	presynapse
s	0098794	cellular_component	postsynapse
s	0098884	biological_process	postsynaptic neurotransmitter receptor internalization

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF

Chain	Residue	Details
S	ILE57-PHE67

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE

Chain	Residue	Details
M	ILE159-GLU179

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY

Chain	Residue	Details
M	ILE263-TYR277

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P53680

Chain	Residue	Details
S	SER140
s	SER140
M	LYS354
m	LYS341
m	LYS345
m	LYS354
a	TYR53
a	LYS57

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q96CW1

Chain	Residue	Details
M	SER45
m	SER45

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:21183079

Chain	Residue	Details
M	THR156
m	THR156

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)