7RTU
Cryo-EM structure of a TTYH2 trans-dimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005225 | molecular_function | volume-sensitive anion channel activity |
| A | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006821 | biological_process | chloride transport |
| A | 0015813 | biological_process | L-glutamate transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034707 | cellular_component | chloride channel complex |
| A | 0072320 | molecular_function | volume-sensitive chloride channel activity |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005225 | molecular_function | volume-sensitive anion channel activity |
| B | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006821 | biological_process | chloride transport |
| B | 0015813 | biological_process | L-glutamate transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034707 | cellular_component | chloride channel complex |
| B | 0072320 | molecular_function | volume-sensitive chloride channel activity |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU45-VAL65 | |
| B | LEU45-VAL65 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 302 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR66-CYS87 | |
| A | ALA235-CYS240 | |
| A | THR407-SER532 | |
| B | TYR66-CYS87 | |
| B | ALA235-CYS240 | |
| B | THR407-SER532 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS88-PHE108 | |
| B | CYS88-PHE108 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 454 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR109-TRP213 | |
| A | ALA262-GLY385 | |
| B | TYR109-TRP213 | |
| B | ALA262-GLY385 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU214-LEU234 | |
| B | LEU214-LEU234 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU241-ALA261 | |
| B | LEU241-ALA261 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE386-LEU406 | |
| B | ILE386-LEU406 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9BSA4 |
| Chain | Residue | Details |
| B | THR199 | |
| A | THR199 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| B | SER504 | |
| A | SER504 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN283 | |
| A | ASN283 |
