7RTU

Cryo-EM structure of a TTYH2 trans-dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005225	molecular_function	volume-sensitive anion channel activity
A	0005254	molecular_function	chloride channel activity
A	0005509	molecular_function	calcium ion binding
A	0005886	cellular_component	plasma membrane
A	0006821	biological_process	chloride transport
A	0015813	biological_process	L-glutamate transmembrane transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0072320	molecular_function	volume-sensitive chloride channel activity
A	1902476	biological_process	chloride transmembrane transport
B	0005225	molecular_function	volume-sensitive anion channel activity
B	0005254	molecular_function	chloride channel activity
B	0005509	molecular_function	calcium ion binding
B	0005886	cellular_component	plasma membrane
B	0006821	biological_process	chloride transport
B	0015813	biological_process	L-glutamate transmembrane transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034707	cellular_component	chloride channel complex
B	0072320	molecular_function	volume-sensitive chloride channel activity
B	1902476	biological_process	chloride transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	LEU45-VAL65
B	LEU45-VAL65

---

site_id	SWS_FT_FI2
Number of Residues	302
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TYR66-CYS87
A	ALA235-CYS240
A	THR407-SER532
B	TYR66-CYS87
B	ALA235-CYS240
B	THR407-SER532

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	CYS88-PHE108
B	CYS88-PHE108

---

site_id	SWS_FT_FI4
Number of Residues	454
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	TYR109-TRP213
A	ALA262-GLY385
B	TYR109-TRP213
B	ALA262-GLY385

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	LEU214-LEU234
B	LEU214-LEU234

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	LEU241-ALA261
B	LEU241-ALA261

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	ILE386-LEU406
B	ILE386-LEU406

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:34824283, ECO:0007744|PDB:7RTT

Chain	Residue	Details
A	GLU113
A	ASP116
B	GLU113
B	ASP116

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	SITE: Essential for the formation of the channel-pore => ECO:0000269|PubMed:31138989

Chain	Residue	Details
A	ARG164
B	ARG164

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9BSA4

Chain	Residue	Details
A	THR199
B	THR199

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER504
B	SER504

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34824283

Chain	Residue	Details
A	ASN129
A	ASN352
B	ASN129
B	ASN352

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN283
B	ASN283

---