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7RTG

Crystal Structure of the Human Adenosine Deaminase 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000255biological_processallantoin metabolic process
A0001666biological_processresponse to hypoxia
A0001701biological_processin utero embryonic development
A0001829biological_processtrophectodermal cell differentiation
A0001889biological_processliver development
A0001890biological_processplacenta development
A0002314biological_processgerminal center B cell differentiation
A0002467biological_processgerminal center formation
A0002636biological_processpositive regulation of germinal center formation
A0002686biological_processnegative regulation of leukocyte migration
A0002901biological_processmature B cell apoptotic process
A0002906biological_processnegative regulation of mature B cell apoptotic process
A0004000molecular_functionadenosine deaminase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006154biological_processadenosine catabolic process
A0006157biological_processdeoxyadenosine catabolic process
A0006196biological_processAMP catabolic process
A0006805biological_processxenobiotic metabolic process
A0006915biological_processapoptotic process
A0006939biological_processsmooth muscle contraction
A0007155biological_processcell adhesion
A0008270molecular_functionzinc ion binding
A0009117biological_processnucleotide metabolic process
A0009168biological_processpurine ribonucleoside monophosphate biosynthetic process
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010035biological_processobsolete response to inorganic substance
A0010460biological_processpositive regulation of heart rate
A0014074biological_processresponse to purine-containing compound
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019239molecular_functiondeaminase activity
A0019722biological_processcalcium-mediated signaling
A0030217biological_processT cell differentiation
A0030324biological_processlung development
A0030890biological_processpositive regulation of B cell proliferation
A0031410cellular_componentcytoplasmic vesicle
A0032261biological_processpurine nucleotide salvage
A0032263biological_processGMP salvage
A0033077biological_processT cell differentiation in thymus
A0033089biological_processpositive regulation of T cell differentiation in thymus
A0033632biological_processregulation of cell-cell adhesion mediated by integrin
A0042100biological_processB cell proliferation
A0042110biological_processT cell activation
A0043066biological_processnegative regulation of apoptotic process
A0043084biological_processpenile erection
A0043101biological_processpurine-containing compound salvage
A0043103biological_processhypoxanthine salvage
A0043605biological_processamide catabolic process
A0044209biological_processAMP salvage
A0045580biological_processregulation of T cell differentiation
A0045582biological_processpositive regulation of T cell differentiation
A0045987biological_processpositive regulation of smooth muscle contraction
A0046059biological_processdAMP catabolic process
A0046061biological_processdATP catabolic process
A0046085biological_processadenosine metabolic process
A0046101biological_processhypoxanthine biosynthetic process
A0046103biological_processinosine biosynthetic process
A0046111biological_processxanthine biosynthetic process
A0046632biological_processalpha-beta T cell differentiation
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0046872molecular_functionmetal ion binding
A0046936molecular_function2'-deoxyadenosine deaminase activity
A0048286biological_processlung alveolus development
A0048541biological_processPeyer's patch development
A0048566biological_processembryonic digestive tract development
A0050728biological_processnegative regulation of inflammatory response
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050852biological_processT cell receptor signaling pathway
A0050862biological_processpositive regulation of T cell receptor signaling pathway
A0050870biological_processpositive regulation of T cell activation
A0050900biological_processleukocyte migration
A0060169biological_processnegative regulation of adenosine receptor signaling pathway
A0060205cellular_componentcytoplasmic vesicle lumen
A0060407biological_processnegative regulation of penile erection
A0070161cellular_componentanchoring junction
A0070242biological_processthymocyte apoptotic process
A0070244biological_processnegative regulation of thymocyte apoptotic process
A0070254biological_processmucus secretion
A0070256biological_processnegative regulation of mucus secretion
A0110148biological_processobsolete biomineralization
B0000255biological_processallantoin metabolic process
B0001666biological_processresponse to hypoxia
B0001701biological_processin utero embryonic development
B0001829biological_processtrophectodermal cell differentiation
B0001889biological_processliver development
B0001890biological_processplacenta development
B0002314biological_processgerminal center B cell differentiation
B0002467biological_processgerminal center formation
B0002636biological_processpositive regulation of germinal center formation
B0002686biological_processnegative regulation of leukocyte migration
B0002901biological_processmature B cell apoptotic process
B0002906biological_processnegative regulation of mature B cell apoptotic process
B0004000molecular_functionadenosine deaminase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006154biological_processadenosine catabolic process
B0006157biological_processdeoxyadenosine catabolic process
B0006196biological_processAMP catabolic process
B0006805biological_processxenobiotic metabolic process
B0006915biological_processapoptotic process
B0006939biological_processsmooth muscle contraction
B0007155biological_processcell adhesion
B0008270molecular_functionzinc ion binding
B0009117biological_processnucleotide metabolic process
B0009168biological_processpurine ribonucleoside monophosphate biosynthetic process
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010035biological_processobsolete response to inorganic substance
B0010460biological_processpositive regulation of heart rate
B0014074biological_processresponse to purine-containing compound
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019239molecular_functiondeaminase activity
B0019722biological_processcalcium-mediated signaling
B0030217biological_processT cell differentiation
B0030324biological_processlung development
B0030890biological_processpositive regulation of B cell proliferation
B0031410cellular_componentcytoplasmic vesicle
B0032261biological_processpurine nucleotide salvage
B0032263biological_processGMP salvage
B0033077biological_processT cell differentiation in thymus
B0033089biological_processpositive regulation of T cell differentiation in thymus
B0033632biological_processregulation of cell-cell adhesion mediated by integrin
B0042100biological_processB cell proliferation
B0042110biological_processT cell activation
B0043066biological_processnegative regulation of apoptotic process
B0043084biological_processpenile erection
B0043101biological_processpurine-containing compound salvage
B0043103biological_processhypoxanthine salvage
B0043605biological_processamide catabolic process
B0044209biological_processAMP salvage
B0045580biological_processregulation of T cell differentiation
B0045582biological_processpositive regulation of T cell differentiation
B0045987biological_processpositive regulation of smooth muscle contraction
B0046059biological_processdAMP catabolic process
B0046061biological_processdATP catabolic process
B0046085biological_processadenosine metabolic process
B0046101biological_processhypoxanthine biosynthetic process
B0046103biological_processinosine biosynthetic process
B0046111biological_processxanthine biosynthetic process
B0046632biological_processalpha-beta T cell differentiation
B0046638biological_processpositive regulation of alpha-beta T cell differentiation
B0046872molecular_functionmetal ion binding
B0046936molecular_function2'-deoxyadenosine deaminase activity
B0048286biological_processlung alveolus development
B0048541biological_processPeyer's patch development
B0048566biological_processembryonic digestive tract development
B0050728biological_processnegative regulation of inflammatory response
B0050850biological_processpositive regulation of calcium-mediated signaling
B0050852biological_processT cell receptor signaling pathway
B0050862biological_processpositive regulation of T cell receptor signaling pathway
B0050870biological_processpositive regulation of T cell activation
B0050900biological_processleukocyte migration
B0060169biological_processnegative regulation of adenosine receptor signaling pathway
B0060205cellular_componentcytoplasmic vesicle lumen
B0060407biological_processnegative regulation of penile erection
B0070161cellular_componentanchoring junction
B0070242biological_processthymocyte apoptotic process
B0070244biological_processnegative regulation of thymocyte apoptotic process
B0070254biological_processmucus secretion
B0070256biological_processnegative regulation of mucus secretion
B0110148biological_processobsolete biomineralization
Functional Information from PROSITE/UniProt
site_idPS00485
Number of Residues7
DetailsA_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP
ChainResidueDetails
ASER291-PRO297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P03958
ChainResidueDetails
AGLU217
BGLU217

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000305|Ref.24
ChainResidueDetails
AHIS15
AHIS17
AHIS214
AASP295
BHIS15
BHIS17
BHIS214
BASP295

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|Ref.24, ECO:0007744|PDB:3IAR
ChainResidueDetails
AASP19
AGLY184
AASP296
BASP19
BGLY184
BASP296

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Important for interaction with adenosine receptors and increasing their affinity for agonists => ECO:0000269|PubMed:23193172
ChainResidueDetails
ALEU58
ALEU62
BLEU58
BLEU62

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Important for catalytic activity => ECO:0000250|UniProtKB:P03958
ChainResidueDetails
AHIS238
BHIS238

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.8
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS54
ALYS232
BLYS54
BLYS232

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PDB entries from 2024-07-24

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