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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7RQW

Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III

Functional Information from GO Data
ChainGOidnamespacecontents
A0001774biological_processmicroglial cell activation
A0003018biological_processvascular process in circulatory system
A0003085biological_processnegative regulation of systemic arterial blood pressure
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008015biological_processblood circulation
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009268biological_processresponse to pH
A0009408biological_processresponse to heat
A0009897cellular_componentexternal side of plasma membrane
A0010447biological_processresponse to acidic pH
A0010459biological_processnegative regulation of heart rate
A0010917biological_processnegative regulation of mitochondrial membrane potential
A0010977biological_processnegative regulation of neuron projection development
A0014047biological_processglutamate secretion
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030425cellular_componentdendrite
A0032591cellular_componentdendritic spine membrane
A0034605biological_processcellular response to heat
A0035091molecular_functionphosphatidylinositol binding
A0035810biological_processpositive regulation of urine volume
A0035815biological_processpositive regulation of renal sodium excretion
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043434biological_processresponse to peptide hormone
A0043679cellular_componentaxon terminus
A0045211cellular_componentpostsynaptic membrane
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045907biological_processpositive regulation of vasoconstriction
A0048681biological_processnegative regulation of axon regeneration
A0050878biological_processregulation of body fluid levels
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0060079biological_processexcitatory postsynaptic potential
A0070588biological_processcalcium ion transmembrane transport
A0071312biological_processcellular response to alkaloid
A0071318biological_processcellular response to ATP
A0071345biological_processcellular response to cytokine stimulus
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071468biological_processcellular response to acidic pH
A0071502biological_processcellular response to temperature stimulus
A0090212biological_processnegative regulation of establishment of blood-brain barrier
A0098703biological_processcalcium ion import across plasma membrane
A1901594biological_processresponse to capsazepine
A1904058biological_processpositive regulation of sensory perception of pain
A1904181biological_processpositive regulation of membrane depolarization
A1904213biological_processnegative regulation of iodide transmembrane transport
A1990090biological_processcellular response to nerve growth factor stimulus
A2000463biological_processpositive regulation of excitatory postsynaptic potential
A2000727biological_processpositive regulation of cardiac muscle cell differentiation
B0001774biological_processmicroglial cell activation
B0003018biological_processvascular process in circulatory system
B0003085biological_processnegative regulation of systemic arterial blood pressure
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008015biological_processblood circulation
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0009268biological_processresponse to pH
B0009408biological_processresponse to heat
B0009897cellular_componentexternal side of plasma membrane
B0010447biological_processresponse to acidic pH
B0010459biological_processnegative regulation of heart rate
B0010917biological_processnegative regulation of mitochondrial membrane potential
B0010977biological_processnegative regulation of neuron projection development
B0014047biological_processglutamate secretion
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030425cellular_componentdendrite
B0032591cellular_componentdendritic spine membrane
B0034605biological_processcellular response to heat
B0035091molecular_functionphosphatidylinositol binding
B0035810biological_processpositive regulation of urine volume
B0035815biological_processpositive regulation of renal sodium excretion
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043434biological_processresponse to peptide hormone
B0043679cellular_componentaxon terminus
B0045211cellular_componentpostsynaptic membrane
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045907biological_processpositive regulation of vasoconstriction
B0048681biological_processnegative regulation of axon regeneration
B0050878biological_processregulation of body fluid levels
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0060079biological_processexcitatory postsynaptic potential
B0070588biological_processcalcium ion transmembrane transport
B0071312biological_processcellular response to alkaloid
B0071318biological_processcellular response to ATP
B0071345biological_processcellular response to cytokine stimulus
B0071356biological_processcellular response to tumor necrosis factor
B0071363biological_processcellular response to growth factor stimulus
B0071468biological_processcellular response to acidic pH
B0071502biological_processcellular response to temperature stimulus
B0090212biological_processnegative regulation of establishment of blood-brain barrier
B0098703biological_processcalcium ion import across plasma membrane
B1901594biological_processresponse to capsazepine
B1904058biological_processpositive regulation of sensory perception of pain
B1904181biological_processpositive regulation of membrane depolarization
B1904213biological_processnegative regulation of iodide transmembrane transport
B1990090biological_processcellular response to nerve growth factor stimulus
B2000463biological_processpositive regulation of excitatory postsynaptic potential
B2000727biological_processpositive regulation of cardiac muscle cell differentiation
C0001774biological_processmicroglial cell activation
C0003018biological_processvascular process in circulatory system
C0003085biological_processnegative regulation of systemic arterial blood pressure
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008015biological_processblood circulation
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0009268biological_processresponse to pH
C0009408biological_processresponse to heat
C0009897cellular_componentexternal side of plasma membrane
C0010447biological_processresponse to acidic pH
C0010459biological_processnegative regulation of heart rate
C0010917biological_processnegative regulation of mitochondrial membrane potential
C0010977biological_processnegative regulation of neuron projection development
C0014047biological_processglutamate secretion
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030425cellular_componentdendrite
C0032591cellular_componentdendritic spine membrane
C0034605biological_processcellular response to heat
C0035091molecular_functionphosphatidylinositol binding
C0035810biological_processpositive regulation of urine volume
C0035815biological_processpositive regulation of renal sodium excretion
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043434biological_processresponse to peptide hormone
C0043679cellular_componentaxon terminus
C0045211cellular_componentpostsynaptic membrane
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0045907biological_processpositive regulation of vasoconstriction
C0048681biological_processnegative regulation of axon regeneration
C0050878biological_processregulation of body fluid levels
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0060079biological_processexcitatory postsynaptic potential
C0070588biological_processcalcium ion transmembrane transport
C0071312biological_processcellular response to alkaloid
C0071318biological_processcellular response to ATP
C0071345biological_processcellular response to cytokine stimulus
C0071356biological_processcellular response to tumor necrosis factor
C0071363biological_processcellular response to growth factor stimulus
C0071468biological_processcellular response to acidic pH
C0071502biological_processcellular response to temperature stimulus
C0090212biological_processnegative regulation of establishment of blood-brain barrier
C0098703biological_processcalcium ion import across plasma membrane
C1901594biological_processresponse to capsazepine
C1904058biological_processpositive regulation of sensory perception of pain
C1904181biological_processpositive regulation of membrane depolarization
C1904213biological_processnegative regulation of iodide transmembrane transport
C1990090biological_processcellular response to nerve growth factor stimulus
C2000463biological_processpositive regulation of excitatory postsynaptic potential
C2000727biological_processpositive regulation of cardiac muscle cell differentiation
D0001774biological_processmicroglial cell activation
D0003018biological_processvascular process in circulatory system
D0003085biological_processnegative regulation of systemic arterial blood pressure
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008015biological_processblood circulation
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0009268biological_processresponse to pH
D0009408biological_processresponse to heat
D0009897cellular_componentexternal side of plasma membrane
D0010447biological_processresponse to acidic pH
D0010459biological_processnegative regulation of heart rate
D0010917biological_processnegative regulation of mitochondrial membrane potential
D0010977biological_processnegative regulation of neuron projection development
D0014047biological_processglutamate secretion
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0030425cellular_componentdendrite
D0032591cellular_componentdendritic spine membrane
D0034605biological_processcellular response to heat
D0035091molecular_functionphosphatidylinositol binding
D0035810biological_processpositive regulation of urine volume
D0035815biological_processpositive regulation of renal sodium excretion
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043434biological_processresponse to peptide hormone
D0043679cellular_componentaxon terminus
D0045211cellular_componentpostsynaptic membrane
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0045907biological_processpositive regulation of vasoconstriction
D0048681biological_processnegative regulation of axon regeneration
D0050878biological_processregulation of body fluid levels
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0060079biological_processexcitatory postsynaptic potential
D0070588biological_processcalcium ion transmembrane transport
D0071312biological_processcellular response to alkaloid
D0071318biological_processcellular response to ATP
D0071345biological_processcellular response to cytokine stimulus
D0071356biological_processcellular response to tumor necrosis factor
D0071363biological_processcellular response to growth factor stimulus
D0071468biological_processcellular response to acidic pH
D0071502biological_processcellular response to temperature stimulus
D0090212biological_processnegative regulation of establishment of blood-brain barrier
D0098703biological_processcalcium ion import across plasma membrane
D1901594biological_processresponse to capsazepine
D1904058biological_processpositive regulation of sensory perception of pain
D1904181biological_processpositive regulation of membrane depolarization
D1904213biological_processnegative regulation of iodide transmembrane transport
D1990090biological_processcellular response to nerve growth factor stimulus
D2000463biological_processpositive regulation of excitatory postsynaptic potential
D2000727biological_processpositive regulation of cardiac muscle cell differentiation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues108
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues104
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues108
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues88
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues112
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues100
DetailsRepeat: {"description":"ANK 3","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues108
DetailsRepeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues144
DetailsRepeat: {"description":"ANK 5","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues92
DetailsRepeat: {"description":"ANK 6","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues88
DetailsRepeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues112
DetailsRegion: {"description":"AD","evidences":[{"source":"PubMed","id":"15190102","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues12
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"10931826","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PDB","id":"2NYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PNN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PDB","id":"2PNN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9R186","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine; by PKA; in vitro","evidences":[{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"PubMed","id":"11884385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

251174

PDB entries from 2026-03-25

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