7RNN
Human ASIC1a-Nb.C1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0001662 | biological_process | behavioral fear response |
| D | 0001975 | biological_process | response to amphetamine |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005272 | molecular_function | sodium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0006816 | biological_process | calcium ion transport |
| D | 0007269 | biological_process | neurotransmitter secretion |
| D | 0007613 | biological_process | memory |
| D | 0008306 | biological_process | associative learning |
| D | 0009986 | cellular_component | cell surface |
| D | 0010447 | biological_process | response to acidic pH |
| D | 0015280 | molecular_function | ligand-gated sodium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0022839 | molecular_function | monoatomic ion-gated channel activity |
| D | 0022890 | molecular_function | inorganic cation transmembrane transporter activity |
| D | 0030425 | cellular_component | dendrite |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0042391 | biological_process | regulation of membrane potential |
| D | 0042995 | cellular_component | cell projection |
| D | 0045202 | cellular_component | synapse |
| D | 0045211 | cellular_component | postsynaptic membrane |
| D | 0046929 | biological_process | negative regulation of neurotransmitter secretion |
| D | 0050915 | biological_process | sensory perception of sour taste |
| D | 0051649 | biological_process | establishment of localization in cell |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0071467 | biological_process | cellular response to pH |
| D | 0098662 | biological_process | inorganic cation transmembrane transport |
| D | 0098793 | cellular_component | presynapse |
| D | 0098839 | cellular_component | postsynaptic density membrane |
| D | 0098978 | cellular_component | glutamatergic synapse |
| D | 0150052 | biological_process | regulation of postsynapse assembly |
| D | 0160128 | molecular_function | pH-gated monoatomic ion channel activity |
Functional Information from PROSITE/UniProt
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| D | TYR305-CYS325 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 360 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Motif: {"description":"GAS motif; ion selectivity filter","evidences":[{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation","evidences":[{"source":"UniProtKB","id":"Q1XA76","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in the inhibition by the spider venom psalmotoxin-1","evidences":[{"source":"PubMed","id":"19654327","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in proton-dependent gating","evidences":[{"source":"PubMed","id":"19654327","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32915133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34319232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CFT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RNN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
