7RNN
Human ASIC1a-Nb.C1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0001662 | biological_process | behavioral fear response |
| D | 0001975 | biological_process | response to amphetamine |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005272 | molecular_function | sodium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0006816 | biological_process | calcium ion transport |
| D | 0007269 | biological_process | neurotransmitter secretion |
| D | 0007613 | biological_process | memory |
| D | 0008306 | biological_process | associative learning |
| D | 0009986 | cellular_component | cell surface |
| D | 0010447 | biological_process | response to acidic pH |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0015280 | molecular_function | ligand-gated sodium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0022839 | molecular_function | monoatomic ion-gated channel activity |
| D | 0022890 | molecular_function | inorganic cation transmembrane transporter activity |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0042391 | biological_process | regulation of membrane potential |
| D | 0045202 | cellular_component | synapse |
| D | 0046929 | biological_process | negative regulation of neurotransmitter secretion |
| D | 0050915 | biological_process | sensory perception of sour taste |
| D | 0051649 | biological_process | establishment of localization in cell |
| D | 0070207 | biological_process | protein homotrimerization |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0071467 | biological_process | cellular response to pH |
| D | 0098662 | biological_process | inorganic cation transmembrane transport |
| D | 0098793 | cellular_component | presynapse |
| D | 0098839 | cellular_component | postsynaptic density membrane |
| D | 0098978 | cellular_component | glutamatergic synapse |
| D | 0150052 | biological_process | regulation of postsynapse assembly |
| D | 0160128 | molecular_function | pH-gated monoatomic ion channel activity |
Functional Information from PROSITE/UniProt
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| D | TYR305-CYS325 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 117 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| D | MET1-LEU45 | |
| D | ASP455-CYS528 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| D | TRP46-PHE69 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 357 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| D | HIS70-GLU427 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000250 |
| Chain | Residue | Details |
| D | ILE428-PHE454 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Important for channel gating => ECO:0000250 |
| Chain | Residue | Details |
| D | TYR71 | |
| D | TRP287 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for channel desensitizing => ECO:0000250 |
| Chain | Residue | Details |
| D | GLU79 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Important for interaction with the spider venom psalmotoxin-1 => ECO:0000269|PubMed:19654327 |
| Chain | Residue | Details |
| D | PHE352 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Key residue for defining the pH sensitivity of ASIC1 (isoform 1) => ECO:0000269|PubMed:19654327 |
| Chain | Residue | Details |
| D | ASP357 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:12578970 |
| Chain | Residue | Details |
| D | SER479 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6NXK8 |
| Chain | Residue | Details |
| D | GLY499 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN368 | |
| D | ASN395 |
