7RJZ
BthTX-II variant a, from Bothrops jararacussu venom, complexed with benzoic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| A | 0050482 | biological_process | arachidonate secretion |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| B | 0050482 | biological_process | arachidonate secretion |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | SITE: Putative hydrophobic membrane-disrupting site (MDiS) => ECO:0000250|UniProtKB:P20474 |
| Chain | Residue | Details |
| A | TRP3 | |
| A | LEU10 | |
| A | LEU16 | |
| B | TRP3 | |
| B | LEU10 | |
| B | LEU16 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Putative membrane-disrupting site (MDiS) => ECO:0000250|UniProtKB:P20474 |
| Chain | Residue | Details |
| A | LYS15 | |
| B | LYS15 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Putative cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:P20474 |
| Chain | Residue | Details |
| A | ARG63 | |
| B | ARG63 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| A | ALA105 | |
| B | ALA105 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| A | LEU114 | |
| B | LEU114 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| A | VAL117 | |
| B | VAL117 |
