Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7RER

HUMAN IMPDH1 TREATED WITH ATP, IMP, AND NAD+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0034774	cellular_component	secretory granule lumen
A	0035578	cellular_component	azurophil granule lumen
A	0046872	molecular_function	metal ion binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006183	biological_process	GTP biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0034774	cellular_component	secretory granule lumen
B	0035578	cellular_component	azurophil granule lumen
B	0046872	molecular_function	metal ion binding
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0003938	molecular_function	IMP dehydrogenase activity
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0006183	biological_process	GTP biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0034774	cellular_component	secretory granule lumen
C	0035578	cellular_component	azurophil granule lumen
C	0046872	molecular_function	metal ion binding
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000166	molecular_function	nucleotide binding
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0003938	molecular_function	IMP dehydrogenase activity
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0006183	biological_process	GTP biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0034774	cellular_component	secretory granule lumen
D	0035578	cellular_component	azurophil granule lumen
D	0046872	molecular_function	metal ion binding
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000166	molecular_function	nucleotide binding
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0003938	molecular_function	IMP dehydrogenase activity
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006177	biological_process	GMP biosynthetic process
E	0006183	biological_process	GTP biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0034774	cellular_component	secretory granule lumen
E	0035578	cellular_component	azurophil granule lumen
E	0046872	molecular_function	metal ion binding
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0003938	molecular_function	IMP dehydrogenase activity
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006177	biological_process	GMP biosynthetic process
F	0006183	biological_process	GTP biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0034774	cellular_component	secretory granule lumen
F	0035578	cellular_component	azurophil granule lumen
F	0046872	molecular_function	metal ion binding
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000166	molecular_function	nucleotide binding
G	0003676	molecular_function	nucleic acid binding
G	0003677	molecular_function	DNA binding
G	0003723	molecular_function	RNA binding
G	0003824	molecular_function	catalytic activity
G	0003938	molecular_function	IMP dehydrogenase activity
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006177	biological_process	GMP biosynthetic process
G	0006183	biological_process	GTP biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0034774	cellular_component	secretory granule lumen
G	0035578	cellular_component	azurophil granule lumen
G	0046872	molecular_function	metal ion binding
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000166	molecular_function	nucleotide binding
H	0003676	molecular_function	nucleic acid binding
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0003824	molecular_function	catalytic activity
H	0003938	molecular_function	IMP dehydrogenase activity
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006177	biological_process	GMP biosynthetic process
H	0006183	biological_process	GTP biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0034774	cellular_component	secretory granule lumen
H	0035578	cellular_component	azurophil granule lumen
H	0046872	molecular_function	metal ion binding
H	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGcGSICiT

Chain	Residue	Details
A	LEU321-THR333

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	ASP256
D	ASP256
C	ASP256
B	ASP256
E	ASP256
H	ASP256
G	ASP256
F	ASP256

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	ALA354
D	ALA354
C	ALA354
B	ALA354
E	ALA354
H	ALA354
G	ALA354
F	ALA354

site_id	SWS_FT_FI3
Number of Residues	56
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	GLU199
D	VAL336
D	GLY366
D	SER425
D	SER426
D	GLN427
C	GLU199
C	ALA249
C	VAL336
C	GLY366
C	SER425
A	ALA249
C	SER426
C	GLN427
B	GLU199
B	ALA249
B	VAL336
B	GLY366
B	SER425
B	SER426
B	GLN427
E	GLU199
A	VAL336
E	ALA249
E	VAL336
E	GLY366
E	SER425
E	SER426
E	GLN427
H	GLU199
H	ALA249
H	VAL336
H	GLY366
A	GLY366
H	SER425
H	SER426
H	GLN427
G	GLU199
G	ALA249
G	VAL336
G	GLY366
G	SER425
G	SER426
G	GLN427
A	SER425
F	GLU199
F	ALA249
F	VAL336
F	GLY366
F	SER425
F	SER426
F	GLN427
A	SER426
A	GLN427
D	GLU199
D	ALA249

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: in other chain => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	GLY251
B	GLY251
B	ARG253
B	ASP256
E	GLY251
E	ARG253
E	ASP256
H	GLY251
H	ARG253
H	ASP256
G	GLY251
A	ARG253
G	ARG253
G	ASP256
F	GLY251
F	ARG253
F	ASP256
A	ASP256
D	GLY251
D	ARG253
D	ASP256
C	GLY251
C	ARG253
C	ASP256

site_id	SWS_FT_FI5
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	GLU254
B	GLU254
B	TYR289
B	ASN312
E	GLU254
E	TYR289
E	ASN312
H	GLU254
H	TYR289
H	ASN312
G	GLU254
A	TYR289
G	TYR289
G	ASN312
F	GLU254
F	TYR289
F	ASN312
A	ASN312
D	GLU254
D	TYR289
D	ASN312
C	GLU254
C	TYR289
C	ASN312

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	MET85
D	MET85
C	MET85
B	MET85
E	MET85
H	MET85
G	MET85
F	MET85

site_id	SWS_FT_FI7
Number of Residues	16
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P50096

Chain	Residue	Details
A	ALA266
E	SER280
H	ALA266
H	SER280
G	ALA266
G	SER280
F	ALA266
F	SER280
A	SER280
D	ALA266
D	SER280
C	ALA266
C	SER280
B	ALA266
B	SER280
E	ALA266

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)