7RD8
Structure of the S. cerevisiae P4B ATPase lipid flippase in the E1-ATP state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005770 | cellular_component | late endosome |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| A | 0006897 | biological_process | endocytosis |
| A | 0007033 | biological_process | vacuole organization |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015031 | biological_process | protein transport |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090555 | molecular_function | phosphatidylethanolamine flippase activity |
| A | 0090556 | molecular_function | phosphatidylserine floppase activity |
| A | 0098629 | biological_process | trans-Golgi network membrane organization |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140331 | biological_process | aminophospholipid translocation |
| A | 0140346 | molecular_function | phosphatidylserine flippase activity |
| A | 0180013 | molecular_function | lysophosphatidylserine flippase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP503-THR509 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 340 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-THR184 | |
| A | THR231-THR367 | |
| A | ASP438 | |
| A | TYR969-GLN970 | |
| A | PHE1042-ARG1052 | |
| A | ASP1100-THR1109 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 220 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE185-VAL205 | |
| A | THR1079-GLY1099 | |
| A | VAL1110-ALA1130 | |
| A | ALA210-LEU230 | |
| A | LEU368-GLY388 | |
| A | ILE417-ASN437 | |
| A | ASP439-LEU459 | |
| A | LEU948-LEU968 | |
| A | GLY971-LEU991 | |
| A | PHE1021-ALA1041 | |
| A | MET1053-ILE1073 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 569 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA206-GLN209 | |
| A | ARG389-LYS416 | |
| A | ARG460-GLY947 | |
| A | ASP992-THR1020 | |
| A | TYR1074-LYS1078 | |
| A | LYS1131-PRO1151 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000305 |
| Chain | Residue | Details |
| A | ASP503 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y2Q0 |
| Chain | Residue | Details |
| A | ASP503 | |
| A | LYS504 | |
| A | THR505 | |
| A | PHE640 | |
| A | ASP882 | |
| A | ASN885 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04191 |
| Chain | Residue | Details |
| A | GLU597 | |
| A | LYS664 | |
| A | ARG693 | |
| A | THR774 | |
| A | GLY775 | |
| A | ASP776 | |
| A | ARG856 | |
| A | LYS862 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P32660 |
| Chain | Residue | Details |
| A | SER642 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34645814, ECO:0007744|PDB:7RD8 |
| Chain | Residue | Details |
| A | LYS645 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P39524 |
| Chain | Residue | Details |
| A | THR694 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8NB49 |
| Chain | Residue | Details |
| A | ASP886 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER102 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER551 |
