7RC9
Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 21
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002224 | biological_process | toll-like receptor signaling pathway |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | GLY62 | |
| A | LEU70 | |
| B | GLY62 | |
| B | LEU70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN97 | |
| A | SER142 | |
| A | LEU229 | |
| A | CYS267 | |
| A | GLU340 | |
| A | LEU344 | |
| A | THR398 | |
| A | LEU425 | |
| A | ASN564 | |
| A | GLU734 | |
| B | ASN97 | |
| B | SER142 | |
| B | LEU229 | |
| B | CYS267 | |
| B | GLU340 | |
| B | LEU344 | |
| B | THR398 | |
| B | LEU425 | |
| B | ASN564 | |
| B | GLU734 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 |
| Chain | Residue | Details |
| A | SER275 | |
| A | TYR377 | |
| A | ILE493 | |
| A | ALA528 | |
| A | GLY572 | |
| A | ILE622 | |
| A | LEU662 | |
| B | SER275 | |
| B | TYR377 | |
| B | ILE493 | |
| B | ALA528 | |
| B | GLY572 | |
| B | ILE622 | |
| B | LEU662 |
