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7R8C

The structure of human ABCG1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005543molecular_functionphospholipid binding
A0005739cellular_componentmitochondrion
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0008203biological_processcholesterol metabolic process
A0009897cellular_componentexternal side of plasma membrane
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A0010875biological_processpositive regulation of cholesterol efflux
A0010887biological_processnegative regulation of cholesterol storage
A0010888biological_processnegative regulation of lipid storage
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0019534molecular_functiontoxin transmembrane transporter activity
A0030301biological_processcholesterol transport
A0032367biological_processintracellular cholesterol transport
A0033344biological_processcholesterol efflux
A0033700biological_processphospholipid efflux
A0033993biological_processresponse to lipid
A0034041molecular_functionABC-type sterol transporter activity
A0034204biological_processlipid translocation
A0034374biological_processlow-density lipoprotein particle remodeling
A0034375biological_processhigh-density lipoprotein particle remodeling
A0034436biological_processglycoprotein transport
A0042632biological_processcholesterol homeostasis
A0042803molecular_functionprotein homodimerization activity
A0042987biological_processamyloid precursor protein catabolic process
A0043531molecular_functionADP binding
A0043691biological_processreverse cholesterol transport
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0046982molecular_functionprotein heterodimerization activity
A0046983molecular_functionprotein dimerization activity
A0050714biological_processpositive regulation of protein secretion
A0055037cellular_componentrecycling endosome
A0055085biological_processtransmembrane transport
A0055091biological_processphospholipid homeostasis
A0071403biological_processcellular response to high density lipoprotein particle stimulus
A0090181biological_processregulation of cholesterol metabolic process
A0090554molecular_functionphosphatidylcholine floppase activity
A0120020molecular_functioncholesterol transfer activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A1902004biological_processpositive regulation of amyloid-beta formation
B0000139cellular_componentGolgi membrane
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005543molecular_functionphospholipid binding
B0005739cellular_componentmitochondrion
B0005768cellular_componentendosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0008203biological_processcholesterol metabolic process
B0009897cellular_componentexternal side of plasma membrane
B0010745biological_processnegative regulation of macrophage derived foam cell differentiation
B0010875biological_processpositive regulation of cholesterol efflux
B0010887biological_processnegative regulation of cholesterol storage
B0010888biological_processnegative regulation of lipid storage
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0019534molecular_functiontoxin transmembrane transporter activity
B0030301biological_processcholesterol transport
B0032367biological_processintracellular cholesterol transport
B0033344biological_processcholesterol efflux
B0033700biological_processphospholipid efflux
B0033993biological_processresponse to lipid
B0034041molecular_functionABC-type sterol transporter activity
B0034204biological_processlipid translocation
B0034374biological_processlow-density lipoprotein particle remodeling
B0034375biological_processhigh-density lipoprotein particle remodeling
B0034436biological_processglycoprotein transport
B0042632biological_processcholesterol homeostasis
B0042803molecular_functionprotein homodimerization activity
B0042987biological_processamyloid precursor protein catabolic process
B0043531molecular_functionADP binding
B0043691biological_processreverse cholesterol transport
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0046982molecular_functionprotein heterodimerization activity
B0046983molecular_functionprotein dimerization activity
B0050714biological_processpositive regulation of protein secretion
B0055037cellular_componentrecycling endosome
B0055085biological_processtransmembrane transport
B0055091biological_processphospholipid homeostasis
B0071403biological_processcellular response to high density lipoprotein particle stimulus
B0090181biological_processregulation of cholesterol metabolic process
B0090554molecular_functionphosphatidylcholine floppase activity
B0120020molecular_functioncholesterol transfer activity
B0140328molecular_functionfloppase activity
B0140359molecular_functionABC-type transporter activity
B1902004biological_processpositive regulation of amyloid-beta formation
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRKRLAIALEL
ChainResidueDetails
ALEU217-LEU231

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues928
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-GLY426
AASN478-CYS506
AVAL556-PHE567
BMET1-GLY426
BASN478-CYS506
BVAL556-PHE567

site_idSWS_FT_FI2
Number of Residues190
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU427-PHE445
BSER568-TYR586
AALA457-LEU477
ASER507-PHE525
ALEU534-PHE555
ASER568-TYR586
BLEU427-PHE445
BALA457-LEU477
BSER507-PHE525
BLEU534-PHE555

site_idSWS_FT_FI3
Number of Residues158
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ALEU446-ALA456
AALA526-SER533
AILE587-SER649
BLEU446-ALA456
BALA526-SER533
BILE587-SER649

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY118
BGLY118

site_idSWS_FT_FI5
Number of Residues10
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:23388354
ChainResidueDetails
ACYS30
BARG406
ACYS154
ACYS315
ACYS394
AARG406
BCYS30
BCYS154
BCYS315
BCYS394

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PDB entries from 2024-08-07

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