7R6Q

State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0003724	molecular_function	RNA helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005635	cellular_component	nuclear envelope
D	0005730	cellular_component	nucleolus
D	0006364	biological_process	rRNA processing
D	0008186	molecular_function	ATP-dependent activity, acting on RNA
D	0016887	molecular_function	ATP hydrolysis activity
D	0030686	cellular_component	90S preribosome
D	0030687	cellular_component	preribosome, large subunit precursor
D	0042254	biological_process	ribosome biogenesis
D	0042273	biological_process	ribosomal large subunit biogenesis
D	0042274	biological_process	ribosomal small subunit biogenesis
D	0042802	molecular_function	identical protein binding
D	0070013	cellular_component	intracellular organelle lumen
D	1990417	biological_process	snoRNA release from pre-rRNA
G	0000470	biological_process	maturation of LSU-rRNA
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006364	biological_process	rRNA processing
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	0042254	biological_process	ribosome biogenesis
G	1990904	cellular_component	ribonucleoprotein complex
i	0000470	biological_process	maturation of LSU-rRNA
i	0002181	biological_process	cytoplasmic translation
i	0003723	molecular_function	RNA binding
i	0003735	molecular_function	structural constituent of ribosome
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005840	cellular_component	ribosome
i	0006412	biological_process	translation
i	0022625	cellular_component	cytosolic large ribosomal subunit
i	0180023	biological_process	cytosolic large ribosomal subunit assembly
K	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0005515	molecular_function	protein binding
K	0005730	cellular_component	nucleolus
K	0006364	biological_process	rRNA processing
K	0019843	molecular_function	rRNA binding
K	0030163	biological_process	protein catabolic process
K	0030674	molecular_function	protein-macromolecule adaptor activity
K	0030687	cellular_component	preribosome, large subunit precursor
K	0042273	biological_process	ribosomal large subunit biogenesis
K	0042802	molecular_function	identical protein binding
K	0043023	molecular_function	ribosomal large subunit binding
K	0070180	molecular_function	large ribosomal subunit rRNA binding
K	0070628	molecular_function	proteasome binding
L	0002181	biological_process	cytoplasmic translation
L	0003735	molecular_function	structural constituent of ribosome
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0022625	cellular_component	cytosolic large ribosomal subunit
m	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
m	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
m	0003674	molecular_function	molecular_function
m	0003677	molecular_function	DNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005730	cellular_component	nucleolus
m	0006364	biological_process	rRNA processing
m	0030687	cellular_component	preribosome, large subunit precursor
m	0042254	biological_process	ribosome biogenesis
m	0042273	biological_process	ribosomal large subunit biogenesis
m	0043021	molecular_function	ribonucleoprotein complex binding
m	0070180	molecular_function	large ribosomal subunit rRNA binding
m	0070545	cellular_component	PeBoW complex
n	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0003729	molecular_function	mRNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005730	cellular_component	nucleolus
n	0006364	biological_process	rRNA processing
n	0019843	molecular_function	rRNA binding
n	0030687	cellular_component	preribosome, large subunit precursor
n	0042254	biological_process	ribosome biogenesis
n	0042273	biological_process	ribosomal large subunit biogenesis
n	0043021	molecular_function	ribonucleoprotein complex binding
n	0070180	molecular_function	large ribosomal subunit rRNA binding
n	0070545	cellular_component	PeBoW complex
N	0000470	biological_process	maturation of LSU-rRNA
N	0002181	biological_process	cytoplasmic translation
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	0180023	biological_process	cytosolic large ribosomal subunit assembly
o	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
o	0003676	molecular_function	nucleic acid binding
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005730	cellular_component	nucleolus
o	0005737	cellular_component	cytoplasm
o	0006364	biological_process	rRNA processing
o	0019843	molecular_function	rRNA binding
o	0030687	cellular_component	preribosome, large subunit precursor
o	0042273	biological_process	ribosomal large subunit biogenesis
o	0043023	molecular_function	ribosomal large subunit binding
t	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
t	0000465	biological_process	exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
t	0003729	molecular_function	mRNA binding
t	0005515	molecular_function	protein binding
t	0005730	cellular_component	nucleolus
t	0022625	cellular_component	cytosolic large ribosomal subunit
t	0030687	cellular_component	preribosome, large subunit precursor
t	0042134	molecular_function	rRNA primary transcript binding
t	0042273	biological_process	ribosomal large subunit biogenesis
v	0003674	molecular_function	molecular_function
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005730	cellular_component	nucleolus
v	0030687	cellular_component	preribosome, large subunit precursor
v	0042273	biological_process	ribosomal large subunit biogenesis
w	0005634	cellular_component	nucleus
w	0006364	biological_process	rRNA processing
w	0008168	molecular_function	methyltransferase activity
X	0000027	biological_process	ribosomal large subunit assembly
X	0002181	biological_process	cytoplasmic translation
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0019843	molecular_function	rRNA binding
X	0022625	cellular_component	cytosolic large ribosomal subunit
X	0030687	cellular_component	preribosome, large subunit precursor

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. IIDEADRiL

Chain	Residue	Details
D	ILE194-LEU202

---

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLTadydaldI

Chain	Residue	Details
X	LYS120-ILE135

---

site_id	PS00634
Number of Residues	33
Details	RIBOSOMAL_L30 Ribosomal protein L30 signature. ILslLrLvEtnTgVfvkltknvypLLkvIapYV

Chain	Residue	Details
t	ILE162-VAL194

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGsdDgTVRVWEI

Chain	Residue	Details
m	LEU452-ILE466

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CkkmgVPYaiVkGKarLG

Chain	Residue	Details
G	CYS170-GLY187

---

site_id	PS01104
Number of Residues	15
Details	RIBOSOMAL_L13E Ribosomal protein L13e signature. RaGRGFTLaEVkaaG

Chain	Residue	Details
L	ARG70-GLY84

---

site_id	PS01190
Number of Residues	11
Details	RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRlIDLIR

Chain	Residue	Details
i	PRO52-ARG62

---

site_id	PS01194
Number of Residues	24
Details	RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGFVIYRvRVrRG

Chain	Residue	Details
N	ASP46-GLY69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Motif: {"description":"DEAD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Motif: {"description":"Bipartite nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	28
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	78
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	118
Details	Region: {"description":"Required for interaction with NOP7","evidences":[{"source":"PubMed","id":"18448671","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---