7R50

Crystal structure of GMP reductase from mycobacterium smegmatis in complex with GMP.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003920	molecular_function	GMP reductase activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006163	biological_process	purine nucleotide metabolic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006166	biological_process	purine ribonucleoside salvage
A	0016491	molecular_function	oxidoreductase activity
A	0032264	biological_process	IMP salvage
B	0003824	molecular_function	catalytic activity
B	0003920	molecular_function	GMP reductase activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0006163	biological_process	purine nucleotide metabolic process
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006166	biological_process	purine ribonucleoside salvage
B	0016491	molecular_function	oxidoreductase activity
B	0032264	biological_process	IMP salvage
C	0003824	molecular_function	catalytic activity
C	0003920	molecular_function	GMP reductase activity
C	0003938	molecular_function	IMP dehydrogenase activity
C	0006163	biological_process	purine nucleotide metabolic process
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006166	biological_process	purine ribonucleoside salvage
C	0016491	molecular_function	oxidoreductase activity
C	0032264	biological_process	IMP salvage
D	0003824	molecular_function	catalytic activity
D	0003920	molecular_function	GMP reductase activity
D	0003938	molecular_function	IMP dehydrogenase activity
D	0006163	biological_process	purine nucleotide metabolic process
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006166	biological_process	purine ribonucleoside salvage
D	0016491	molecular_function	oxidoreductase activity
D	0032264	biological_process	IMP salvage
E	0003824	molecular_function	catalytic activity
E	0003920	molecular_function	GMP reductase activity
E	0003938	molecular_function	IMP dehydrogenase activity
E	0006163	biological_process	purine nucleotide metabolic process
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006166	biological_process	purine ribonucleoside salvage
E	0016491	molecular_function	oxidoreductase activity
E	0032264	biological_process	IMP salvage
F	0003824	molecular_function	catalytic activity
F	0003920	molecular_function	GMP reductase activity
F	0003938	molecular_function	IMP dehydrogenase activity
F	0006163	biological_process	purine nucleotide metabolic process
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006166	biological_process	purine ribonucleoside salvage
F	0016491	molecular_function	oxidoreductase activity
F	0032264	biological_process	IMP salvage
G	0003824	molecular_function	catalytic activity
G	0003920	molecular_function	GMP reductase activity
G	0003938	molecular_function	IMP dehydrogenase activity
G	0006163	biological_process	purine nucleotide metabolic process
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006166	biological_process	purine ribonucleoside salvage
G	0016491	molecular_function	oxidoreductase activity
G	0032264	biological_process	IMP salvage
H	0003824	molecular_function	catalytic activity
H	0003920	molecular_function	GMP reductase activity
H	0003938	molecular_function	IMP dehydrogenase activity
H	0006163	biological_process	purine nucleotide metabolic process
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006166	biological_process	purine ribonucleoside salvage
H	0016491	molecular_function	oxidoreductase activity
H	0032264	biological_process	IMP salvage
I	0003824	molecular_function	catalytic activity
I	0003920	molecular_function	GMP reductase activity
I	0003938	molecular_function	IMP dehydrogenase activity
I	0006163	biological_process	purine nucleotide metabolic process
I	0006164	biological_process	purine nucleotide biosynthetic process
I	0006166	biological_process	purine ribonucleoside salvage
I	0016491	molecular_function	oxidoreductase activity
I	0032264	biological_process	IMP salvage
J	0003824	molecular_function	catalytic activity
J	0003920	molecular_function	GMP reductase activity
J	0003938	molecular_function	IMP dehydrogenase activity
J	0006163	biological_process	purine nucleotide metabolic process
J	0006164	biological_process	purine nucleotide biosynthetic process
J	0006166	biological_process	purine ribonucleoside salvage
J	0016491	molecular_function	oxidoreductase activity
J	0032264	biological_process	IMP salvage
K	0003824	molecular_function	catalytic activity
K	0003920	molecular_function	GMP reductase activity
K	0003938	molecular_function	IMP dehydrogenase activity
K	0006163	biological_process	purine nucleotide metabolic process
K	0006164	biological_process	purine nucleotide biosynthetic process
K	0006166	biological_process	purine ribonucleoside salvage
K	0016491	molecular_function	oxidoreductase activity
K	0032264	biological_process	IMP salvage
L	0003824	molecular_function	catalytic activity
L	0003920	molecular_function	GMP reductase activity
L	0003938	molecular_function	IMP dehydrogenase activity
L	0006163	biological_process	purine nucleotide metabolic process
L	0006164	biological_process	purine nucleotide biosynthetic process
L	0006166	biological_process	purine ribonucleoside salvage
L	0016491	molecular_function	oxidoreductase activity
L	0032264	biological_process	IMP salvage
M	0003824	molecular_function	catalytic activity
M	0003920	molecular_function	GMP reductase activity
M	0003938	molecular_function	IMP dehydrogenase activity
M	0006163	biological_process	purine nucleotide metabolic process
M	0006164	biological_process	purine nucleotide biosynthetic process
M	0006166	biological_process	purine ribonucleoside salvage
M	0016491	molecular_function	oxidoreductase activity
M	0032264	biological_process	IMP salvage
N	0003824	molecular_function	catalytic activity
N	0003920	molecular_function	GMP reductase activity
N	0003938	molecular_function	IMP dehydrogenase activity
N	0006163	biological_process	purine nucleotide metabolic process
N	0006164	biological_process	purine nucleotide biosynthetic process
N	0006166	biological_process	purine ribonucleoside salvage
N	0016491	molecular_function	oxidoreductase activity
N	0032264	biological_process	IMP salvage
O	0003824	molecular_function	catalytic activity
O	0003920	molecular_function	GMP reductase activity
O	0003938	molecular_function	IMP dehydrogenase activity
O	0006163	biological_process	purine nucleotide metabolic process
O	0006164	biological_process	purine nucleotide biosynthetic process
O	0006166	biological_process	purine ribonucleoside salvage
O	0016491	molecular_function	oxidoreductase activity
O	0032264	biological_process	IMP salvage
P	0003824	molecular_function	catalytic activity
P	0003920	molecular_function	GMP reductase activity
P	0003938	molecular_function	IMP dehydrogenase activity
P	0006163	biological_process	purine nucleotide metabolic process
P	0006164	biological_process	purine nucleotide biosynthetic process
P	0006166	biological_process	purine ribonucleoside salvage
P	0016491	molecular_function	oxidoreductase activity
P	0032264	biological_process	IMP salvage

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: Thioimidate intermediate => ECO:0000250|UniProtKB:P50097

Chain	Residue	Details
A	MET302
J	MET302
K	MET302
L	MET302
M	MET302
N	MET302
O	MET302
P	MET302
B	MET302
C	MET302
D	MET302
E	MET302
F	MET302
G	MET302
H	MET302
I	MET302

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P50097

Chain	Residue	Details
A	ILE245
E	VAL295
F	ILE245
F	VAL295
G	ILE245
G	VAL295
H	ILE245
H	VAL295
I	ILE245
I	VAL295
J	ILE245
A	VAL295
J	VAL295
K	ILE245
K	VAL295
L	ILE245
L	VAL295
M	ILE245
M	VAL295
N	ILE245
N	VAL295
O	ILE245
B	ILE245
O	VAL295
P	ILE245
P	VAL295
B	VAL295
C	ILE245
C	VAL295
D	ILE245
D	VAL295
E	ILE245

---