Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7R4H

phospho-STING binding to adaptor protein complex-1

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0002090	biological_process	regulation of receptor internalization
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006878	biological_process	intracellular copper ion homeostasis
C	0006886	biological_process	intracellular protein transport
C	0012505	cellular_component	endomembrane system
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016192	biological_process	vesicle-mediated transport
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030017	cellular_component	sarcomere
C	0031252	cellular_component	cell leading edge
C	0032991	cellular_component	protein-containing complex
C	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0060292	biological_process	long-term synaptic depression
C	0070062	cellular_component	extracellular exosome
C	0097061	biological_process	dendritic spine organization
C	0098586	biological_process	cellular response to virus
C	1990386	biological_process	mitotic cleavage furrow ingression
G	0006886	biological_process	intracellular protein transport
G	0016192	biological_process	vesicle-mediated transport
G	0030117	cellular_component	membrane coat
H	0000139	cellular_component	Golgi membrane
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0002090	biological_process	regulation of receptor internalization
H	0003723	molecular_function	RNA binding
H	0003924	molecular_function	GTPase activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006878	biological_process	intracellular copper ion homeostasis
H	0006886	biological_process	intracellular protein transport
H	0012505	cellular_component	endomembrane system
H	0014069	cellular_component	postsynaptic density
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0016192	biological_process	vesicle-mediated transport
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030017	cellular_component	sarcomere
H	0031252	cellular_component	cell leading edge
H	0032991	cellular_component	protein-containing complex
H	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
H	0043005	cellular_component	neuron projection
H	0045202	cellular_component	synapse
H	0060292	biological_process	long-term synaptic depression
H	0070062	cellular_component	extracellular exosome
H	0097061	biological_process	dendritic spine organization
H	0098586	biological_process	cellular response to virus
H	1990386	biological_process	mitotic cleavage furrow ingression
M	0005515	molecular_function	protein binding
M	0005765	cellular_component	lysosomal membrane
M	0005769	cellular_component	early endosome
M	0005794	cellular_component	Golgi apparatus
M	0005802	cellular_component	trans-Golgi network
M	0005829	cellular_component	cytosol
M	0006886	biological_process	intracellular protein transport
M	0015031	biological_process	protein transport
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
M	0030121	cellular_component	AP-1 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0030136	cellular_component	clathrin-coated vesicle
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0032438	biological_process	melanosome organization
M	0032588	cellular_component	trans-Golgi network membrane
M	0035615	molecular_function	clathrin adaptor activity
M	0035646	biological_process	endosome to melanosome transport
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0045202	cellular_component	synapse
M	0060155	biological_process	platelet dense granule organization
M	1903232	biological_process	melanosome assembly
S	0000139	cellular_component	Golgi membrane
S	0005515	molecular_function	protein binding
S	0005765	cellular_component	lysosomal membrane
S	0005769	cellular_component	early endosome
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0005905	cellular_component	clathrin-coated pit
S	0006605	biological_process	protein targeting
S	0006886	biological_process	intracellular protein transport
S	0015031	biological_process	protein transport
S	0016020	cellular_component	membrane
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030121	cellular_component	AP-1 adaptor complex
S	0030659	cellular_component	cytoplasmic vesicle membrane
S	0031410	cellular_component	cytoplasmic vesicle
S	0032588	cellular_component	trans-Golgi network membrane
S	0035615	molecular_function	clathrin adaptor activity
S	0060155	biological_process	platelet dense granule organization
S	1903232	biological_process	melanosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. LVYKryasLYF

Chain	Residue	Details
S	LEU57-PHE67

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. VSWRse.GikYrkNeVFLDVIE

Chain	Residue	Details
M	VAL157-GLU177

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY

Chain	Residue	Details
M	ILE253-TYR267

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0000250\|UniProtKB:Q9BXS5

Chain	Residue	Details
M	SER2
H	GLY24

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:17242355, ECO:0007744\|PubMed:21183079

Chain	Residue	Details
M	THR152
M	THR154

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q32Q06

Chain	Residue	Details
M	THR223
H	ALA160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)