7R3J

Nativ complex of PqsE and RhlR with the synthetic antagonist mBTL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0044550	biological_process	secondary metabolite biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0044550	biological_process	secondary metabolite biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001216	molecular_function	DNA-binding transcription activator activity
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005737	cellular_component	cytoplasm
C	0006355	biological_process	regulation of DNA-templated transcription
C	0009372	biological_process	quorum sensing
C	0010467	biological_process	gene expression
C	0032993	cellular_component	protein-DNA complex
C	0038023	molecular_function	signaling receptor activity
C	0045862	biological_process	positive regulation of proteolysis
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046889	biological_process	positive regulation of lipid biosynthetic process
C	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
C	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001216	molecular_function	DNA-binding transcription activator activity
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005737	cellular_component	cytoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0009372	biological_process	quorum sensing
D	0010467	biological_process	gene expression
D	0032993	cellular_component	protein-DNA complex
D	0038023	molecular_function	signaling receptor activity
D	0045862	biological_process	positive regulation of proteolysis
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046889	biological_process	positive regulation of lipid biosynthetic process
D	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
D	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00622
Number of Residues	28
Details	HTH_LUXR_1 LuxR-type HTH domain signature. GksSgeIAiiLsIsesTVnfHhkNIqkK

Chain	Residue	Details
C	GLY195-LYS222

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19788310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20419351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27082157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	130
Details	Domain: {"description":"HTH luxR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	38
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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