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7R3G

PROSS optimitzed variant of RhlR (75 mutations) in complex with the synthetic antagonist mBTL

Functional Information from GO Data
ChainGOidnamespacecontents
A0000976molecular_functiontranscription cis-regulatory region binding
A0001216molecular_functionDNA-binding transcription activator activity
A0001217molecular_functionDNA-binding transcription repressor activity
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0005737cellular_componentcytoplasm
A0006355biological_processregulation of DNA-templated transcription
A0009372biological_processquorum sensing
A0010467biological_processgene expression
A0032993cellular_componentprotein-DNA complex
A0038023molecular_functionsignaling receptor activity
A0045862biological_processpositive regulation of proteolysis
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0046889biological_processpositive regulation of lipid biosynthetic process
A0062162biological_processpositive regulation of pyocyanine biosynthetic process
A1900378biological_processpositive regulation of secondary metabolite biosynthetic process
B0000976molecular_functiontranscription cis-regulatory region binding
B0001216molecular_functionDNA-binding transcription activator activity
B0001217molecular_functionDNA-binding transcription repressor activity
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0005737cellular_componentcytoplasm
B0006355biological_processregulation of DNA-templated transcription
B0009372biological_processquorum sensing
B0010467biological_processgene expression
B0032993cellular_componentprotein-DNA complex
B0038023molecular_functionsignaling receptor activity
B0045862biological_processpositive regulation of proteolysis
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0046889biological_processpositive regulation of lipid biosynthetic process
B0062162biological_processpositive regulation of pyocyanine biosynthetic process
B1900378biological_processpositive regulation of secondary metabolite biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00622
Number of Residues28
DetailsHTH_LUXR_1 LuxR-type HTH domain signature. GktSaeIAkiLgIsesTVnfHlkNIqkK
ChainResidueDetails
BGLY195-LYS222

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues130
DetailsDomain: {"description":"HTH luxR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues38
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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